Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/02 16:37:23」(JST)

English Journal

Comparative analysis of the therapeutic effects of long-acting and short-acting loop diuretics in the treatment of chronic heart failure using (123)I-metaiodobenzylguanidine scintigraphy.

Hisatake S, Nanjo S, Fujimoto S, Yamashina S, Yuzawa H, Namiki A, Nakano H, Yamazaki J.SourceDepartment of Cardiovascular Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan. s-hisata@td5.so-net.ne.jp
European journal of heart failure.Eur J Heart Fail.2011 Aug;13(8):892-8. Epub 2011 May 20.
AIMS: Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting fur
PMID 21602550

Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide.

Harada K, Izawa H, Nishizawa T, Hirashiki A, Murase Y, Kobayashi M, Isobe S, Cheng XW, Noda A, Nagata K, Yokota M, Murohara T.SourceDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. haraken@med.nagoya-u.ac.jp
Journal of cardiovascular pharmacology.J Cardiovasc Pharmacol.2009 Jun;53(6):468-73.
Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the
PMID 19430310

Assessment of diuretic effects and changes in plasma aldosterone concentration following oral administration of a single dose of furosemide or azosemide in healthy dogs.

Hori Y, Katou A, Tsubaki M, Kanai K, Nakao R, Hoshi F, Itoh N, Higuchi S.SourceDepartment of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
American journal of veterinary research.Am J Vet Res.2008 Dec;69(12):1664-9.
OBJECTIVE: To determine the diuretic effects and changes in plasma aldosterone concentration (PAC) following oral administration of a single dose of furosemide or azosemide in healthy dogs.ANIMALS: 8 mixed-breed dogs.PROCEDURES: A single dose of furosemide (2 mg/kg), azosemide (1, 5, or 10 mg/kg), o
PMID 19046016

駒田敬則,吉田泉,佐久間由紀,森穂波,雨宮守正,中里優一,田部井薫
自治医科大学紀要 33, 79-90, 2011-03-01
現在ループ利尿薬を服用している血清Cr値1.5mg/dl以上の外来患者を対象とし,文書にて同意を得られた34名を対象とした。投与薬剤の順番をランダム化して,アゾセミドまたはフロセミドを,1-2ヶ月毎に交互に投与した。その結果,アゾセミド60mgとフロセミド40mgを同等力価と考えて交互に投与した場合,血圧,体重,尿量,尿中Na排泄量に差はなく,血液検査データ,尿中電解質などにも差は無かった。尿蛋白 …
NAID 110008506955

Rationale and Design of a Randomized Trial to Assess the Effects of Diuretics in Heart Failure : Japanese Multicenter Evaluation of Long- vs Short-Acting Diuretics in Congestive Heart Failure(J-MELODIC)

The J-MELODIC Program Committee
Circulation journal : official journal of the Japanese Circulation Society 71(7), 1137-1140, 2007-06-20
… The present study was designed to compare the therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in patients with HF to test the hypothesis that long-acting diuretics are superior therapy. …
NAID 110006318418

リンク元

Azosemide
Systematic (IUPAC) name
	2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	27589-33-9
ATC code	?
PubChem	CID 2273
ChemSpider	2186
UNII	MR40VT1L8Z
KEGG	D01323
ChEBI	CHEBI:31248
ChEMBL	CHEMBL1097235
Chemical data
Formula	C12H11ClN6O2S2
Mol. mass	370.84 g/mol
	SMILES O=S(=O)(N)c2c(Cl)cc(c(c1nnnn1)c2)NCc3sccc3;
	InChI InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) ; Key:HMEDEBAJARCKCT-UHFFFAOYSA-N ;
(what is this?) (verify);