English Journal

Identification of active antiviral compounds against a New York isolate of West Nile virus.

Morrey JD1, Smee DF, Sidwell RW, Tseng C.
Antiviral research.Antiviral Res.2002 Jul;55(1):107-16.
The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies for this disease. A chemotherapeutic approach may be a reasonable strategy because the virus infection is typically not chronic and antiviral drugs have been identified to be effecti
PMID 12076755

In vitro metabolism studies of the prodrug, 2',3',5'-triacetyl-6-azauridine, utilizing an automated analytical system.

Zhou J1, Riley CM, Schowen RL.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2001 Dec;26(5-6):701-16.
The purpose was to study in vitro metabolism of 2',3',5'-triacetyl-6-azauridine (1) by porcine liver esterase (PLE) and in human plasma using an automated analytical system developed previously. A gradient-LC method was developed to study the concentration-time course of 1 and its metabolites. A fas
PMID 11600283

Automated analytical systems for drug development studies. V. A system for enzyme kinetic studies.

Zhou J1, Shearer EC, Hong J, Riley CM, Schowen RL.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.1996 Sep;14(12):1691-8.
Two similar automated analytical systems using liquid chromatography (LC) and microdialysis as an on-line sampling technique were applied to studies of enzyme kinetics. 2',3',5'-Triacetyl-6-azauridine (azaribine) with porcine liver esterase (PLE) and N-acetylphenylalanyl-3,5-diiodotyrosine (AcFY') w
PMID 8887716