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- self-reactive
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English Journal
- Humoral autoimmunity: A failure of regulatory T cells?
- Dhaeze T1, Stinissen P1, Liston A2, Hellings N3.
- Autoimmunity reviews.Autoimmun Rev.2015 Aug;14(8):735-741. doi: 10.1016/j.autrev.2015.04.006. Epub 2015 Apr 23.
- Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in co
- PMID 25913138
- Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors - Recommendations for methods and experimental designs.
- Losen M1, Martinez-Martinez P2, Molenaar PC2, Lazaridis K3, Tzartos S3, Brenner T4, Duan RS5, Luo J6, Lindstrom J6, Kusner L7.
- Experimental neurology.Exp Neurol.2015 Aug;270:18-28. doi: 10.1016/j.expneurol.2015.03.010. Epub 2015 Mar 18.
- Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR) is characterized by a chronic, fatigable weakness of voluntary muscles. The production of autoantibodies involves the dysregulation of T cells which provide the environment for the development of autoreactive B cells. T
- PMID 25796590
- Identification of autoreactive CD8(+) T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients.
- Li Y1, Zhou L2, Li Y1, Zhang J1, Guo B1, Meng G3, Chen X1, Zheng Q4, Zhang L1, Zhang M5, Wang L6.
- Clinical immunology (Orlando, Fla.).Clin Immunol.2015 Jul;159(1):63-71. doi: 10.1016/j.clim.2015.04.017. Epub 2015 May 6.
- ChgA has recently been identified as the autoantigen for diabetogenic CD4(+) T cells in NOD mice and T1D patients. However, autoreactive CD8(+) T-cell responses targeting ChgA haven't been studied yet. Here several HLA-A*0201-restricted peptides derived from mChgA and hChgA were selected by an integ
- PMID 25958206
Japanese Journal
- 全身性エリテマトーデス(SLE)患者B細胞におけるケモカイン受容体発現異常
- 好川 真以子,中山田 真吾,岩田 慈,久保 智史,湯之上 直樹,汪 曉珮,田中 良哉
- 日本臨床免疫学会会誌 38(1), 65-68, 2015
- SLEは全身性自己免疫疾患であり,その病態形成過程において自己反応性B細胞が中心的に関与し,特にメモリーB細胞への分化偏向と活性化が重要であることが明らかにされてきた.しかし,B細胞の質的な異常とその誘導機構については依然不詳な点が多い.これに比し,T細胞においてはエフェクター細胞への分化,機能的な役割が細分化され,マスター転写因子やケモカイン受容体の発現パターンの異なる機能的なサブセットの存 …
- NAID 130004875953
- 自己反応性B細胞の選択的除去による自己免疫疾患の治療法の検討 (特集 自己免疫疾患の免疫学的治療新戦略)
Related Links
- autoreactive pertaining to an immune response directed against the body's own tissues. ... Richardson discovered that some lupus-causing drugs alter gene activity or expression in normal "helper" lymphocytes, converting them into autoreactive ...
- Definition of autoreactive in the Definitions.net dictionary. Meaning of autoreactive. What does autoreactive mean? Information and translations of autoreactive in the most comprehensive dictionary definitions resource on the web.
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- 関
- autoreactive
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- 英
- self-reactive、autoreactive