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  • Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli.
  • Lee SB1, Park SK, Kim YS.
  • AMB Express.AMB Express.2015 Dec;5(1):142. doi: 10.1186/s13568-015-0142-3. Epub 2015 Aug 25.
  • Follistatin (FST) is a cysteine-rich autocrine glycoprotein and plays an important role in mammalian prenatal and postnatal development. FST binds to and inhibit myostatin (MSTN), a potent negative regulator of skeletal muscle growth, and FST abundance enhances muscle growth in animals via inhibitio
  • PMID 26302688
  • ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.
  • Muniyan S1, Chen SJ1, Lin FF1, Wang Z1, Mehta PP1, Batra SK2, Lin MF3.
  • Cellular signalling.Cell Signal.2015 Nov;27(11):2261-71. doi: 10.1016/j.cellsig.2015.08.002. Epub 2015 Aug 6.
  • While androgen deprivation therapy (ADT) reduces tumor burden, autocrine growth factor loops such as human epidermal growth factor receptor 2 (HER2/ErbB-2/neu) have been proposed to contribute to prostate cancer (PCa) survival and relapse. However, the role of ErbB-2 in regulating androgen-sensitive
  • PMID 26257301
  • Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.
  • Ma H1, Wardega P1, Mazaud D1, Klosowska-Wardega A1, Jurek A1, Engström U1, Lennartsson J2, Heldin CH1.
  • Cellular signalling.Cell Signal.2015 Nov;27(11):2209-19. doi: 10.1016/j.cellsig.2015.07.020. Epub 2015 Jul 30.
  • Histidine domain-containing protein tyrosine phosphatase (HD-PTP) is a putative phosphatase that has been shown to affect the signaling and downregulation of certain receptor tyrosine kinases. To investigate if HD-PTP affects platelet-derived growth factor receptor β (PDGFRβ) signaling, we employe
  • PMID 26232618


  • Regulation of neuropeptide Y Y1 receptor expression by bone morphogenetic protein 2 in C2C12 myoblasts
  • Kurebayashi Naoko,Sato Mari,Fujisawa Toshiaki,Fukushima Kazuaki,Tamura Masato
  • Biochemical and Biophysical Research Communications 439(4), 506-510, 2013-10-04
  • … These results show that BMP2 signaling regulates Y1 receptor gene expression, and raises the possibility that NPY acts in osteoblasts via an autocrine mechanism. …
  • NAID 120005324568
  • 口腔扁平上皮癌細胞における自律増殖性の解析
  • 大西 祐一,渡辺 昌広,安井 大樹,藤井 智子,井上 洋士,伊達岡 聖,赤根 昌樹,中嶋 正博,覚道 健治
  • 歯科医学 76(2), 110-114, 2013-09-25
  • … がみられた.さらにHSC4の培地中にSheddase阻害剤であるTAPl-2とγ-secretase阻害剤であるDAPTを添加したところ,TAPl-2処理単独で,増殖が抑制された.また,EGFR阻害剤であるAG1478を添加した場合も,増殖抑制が確認された.これらの結果は,HSC4はectodomain sheddingにより細胞外に放出された成長因子であるEGFRリガンドがEGFRを刺激するautocrine-loop機構によって無血清培養下で自律増殖でき,HSC3にはそのシステムが働いていない可能性を示した. …
  • NAID 110009685610
  • 口腔扁平上皮癌細胞における自律増殖性の解析
  • 大西 祐一,渡辺 昌広,安井 大樹 [他]
  • 歯科医学 = Journal of Osaka Odontological Society 76(2), 110-114, 2013-09
  • NAID 40019814435


autocrine /au·to·crine/ (-krin) denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the cell type that produced it. au·to·crine (ô t-kr n, -kr n) adj. Of or relating to self-stimulation through ...
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拡張検索autocrine motility factor」「autocrine secretion」「autocrine signaling




autocrine motility factor」

  [★] 自己分泌型細胞運動刺激因子

  • (癌細胞の浸潤や転移に関与するサイトカイン)自己分泌型細胞運動刺激因子

autocrine secretion」



autocrine signaling」

  [★] 自己分泌シグナル伝達