atovaquone

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/08 22:56:03」(JST)

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英文文献

  • The therapeutic efficacy of two antibabesial strategies against Babesia gibsoni.
  • Lin EC, Chueh LL, Lin CN, Hsieh LE, Su BL.SourceInstitute of Veterinary Clinical Sciences, National Taiwan University, Taipei, Taiwan; National Taiwan University Veterinary Hospital, National Taiwan University, Taipei, Taiwan.
  • Veterinary parasitology.Vet Parasitol.2012 May 25;186(3-4):159-64. Epub 2011 Dec 6.
  • Various combination strategies for treating Babesia gibsoni have been described. However, relapses after administering some combinations of antibabesial drugs and the presence of drug-resistant B. gibsoni still pose significant challenges to veterinarians. To compare the efficacy of a combination of
  • PMID 22222008
  • Early treatment failure during treatment of plasmodium falciparum malaria with atovaquoneproguanil in the republic of ivory coast.
  • Wurtz N, Pascual A, Marin-Jauffre A, Bouchiba H, Benoit N, Desbordes M, Martelloni M, Pommier de Santi V, Richa G, Taudon N, Pradines B, Briolant S.AbstractABSTRACT: The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone and proguanil (Malarone(R)) has shown high efficacy against Plasmodium falciparum with only mild sideeffects. Treatment failures have been attributed to suboptimal dosages or to parasite resistance resulting from a point mutation in the cytochrome b gene. In this paper, a case of early treatment failure was reported in a patient treated with atovaquone-proguanil; this failure was not associated with a mutation in the parasite cytochrome b gene, with impaired drug bioavailability, or with re-infection.
  • Malaria journal.Malar J.2012 May 2;11(1):146. [Epub ahead of print]
  • ABSTRACT: The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone and proguanil (Malarone(R)) has shown high efficacy against Plasmodium falciparum with only mild sideeffects. Treatment failures have b
  • PMID 22551095

和文文献

  • ニューモシスチス肺炎の治療 (特集 ニューモシスチス肺炎 update)
  • 青木 孝弘,菊池 嘉
  • 日本胸部臨床 69(2), 131-136, 2010-02
  • NAID 40016986043
  • 病原性酵母Candida albicansのin vitro生育に対するatovaquoneとリチウムの併用効果
  • 皆川 信子,上原 麻理子,関 志織,新田 あゆみ,古河原 健人
  • YAKUGAKU ZASSHI 130(2), 247-251, 2010
  • …   Atovaquone, an analog of ubiquinone, binds tightly to the ubiquinol oxidation site (Qo site) of parasite cytochrome bc1 complex to inhibit electron transport at concentrations far lower than those at which the mammalian system is affected. … To treat Pneumocystis jirovecii and Plasmodium falciparum infections, atovaquone has been used worldwide whereas it is unapproved in Japan. …
  • NAID 130000171294

関連リンク

Atovaquone (alternative spelling: atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4- naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. It is manufactured in the ...

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