Multiple rod-shaped bacteria shown between the larger white blood cells at urinary microscopy from a person with urinary tract infection.
Specialty
Emergency medicine, Infectious disease
Types
Asymptomatic, symptomatic[1][2]
Diagnostic method
Urinalysis, urine culture[3]
Differential diagnosis
Contamination[1]
Treatment
Based on symptoms or risk factors[4][3]
Frequency
Asymptomatic: 3% (middle aged women), up to 50% (women in nursing homes)[5] Symptomatic: up to 10% of women a year[6][7]
Bacteriuria is the presence of bacteria in urine.[1] It is divided into two main types, those with symptoms (urinary tract infection) and those without (asymptomatic bacteriuria).[1][2] Diagnosis is by urinalysis or urine culture.[3]Escherichia coli is the most common bacterium found.[1] Most people without symptoms should not be tested for the condition.[3] Differential diagnosis include contamination.[1] Using special techniques certain non-disease causing bacteria have also been found in the urine of healthy people.[8] These are part of the resident microbiota.[8]
If symptoms are present treatment is generally with antibiotics.[3] Bacteriuria without symptoms generally does not require treatment.[4] Exceptions include during pregnancy, those who have had a recent kidney transplant, young children with significant vesicoureteral reflux, and in those undergoing surgery of the urinary tract.[4][3]
Bacteriuria without symptoms is present in about 3% of otherwise healthy middle aged women.[5] Among those in nursing homes rates are as high as 50% among women and 40% in men.[5] In those with a long term indwelling urinary catheter rates are 100%.[5] Up to 10% of women have a urinary tract infection in a given year and half of women having at least one infection at some point in their lives.[6][7]
Contents
1Signs and symptoms
1.1Asymptomatic bacteriuria
1.2Symptomatic bacteriuria
2Diagnosis
3Screening
4Treatment
4.1Asymptomatic bacteriuria
4.2Symptomatic bacteriuria
5Epidemiology
6References
7External links
Signs and symptoms
Asymptomatic bacteriuria
Asymptomatic bacteriuria is bacteriuria without accompanying symptoms of a urinary tract infection. It is more common in women, in the elderly, in residents of long-term care facilities, and in people with diabetes, bladder catheters and spinal cord injuries. People with a long-term Foley catheter uniformly show bacteriuria. Chronic asymptomatic bacteriuria without urinary tract infection symptoms occurs in as many as 50% of the population in long-term care.[9]
In pregnant women bacteriuria is associated with low birth weight, preterm delivery, and infection of the newborn.[10][11] Bacteriuria in pregnancy also increase the risk of preeclampsia.[11]
Symptomatic bacteriuria
Main article: Urinary tract infection
Symptomatic bacteriuria is bacteriuria with the accompanying symptoms of a urinary tract infection (such as frequent urination, painful urination, fever, back pain). Symptomatic bacteriuria can be indicative of a urinary tract infection like pyelonephritis or cystitis. The most common type of bacteriuria associated with urinary tract infections is Escherichia coli which is a gram-negative rod-shaped bacteria.
Diagnosis
Testing for bacteriuria is often performed in those with symptoms of a urinary tract infection. Testing is often done in other scenarios as in failure to thrive of a newborn or confusion in the elderly. Screening for bacteriuria is recommended in pregnancy as there is evidence that asymptomatic bacteriuria can lead to low birth weight and preterm delivery.
Bacteriuria can be detected by urine dipstick test. The urinary nitrite test will be able to detect any nitrate-reducing bacteria in the urine. The leukocyte esterase test detects the presence of leukocytes (white blood cells) in the urine which can be associated with a urinary tract infection.The urine dipstick test is readily available and provides fast results.
Microscopy can also be used to detect bacteriuria. It is more specific, especially when used with gram staining, but requires more time and equipment.
The gold standard for detecting bacteriuria is a bacterial culture which identifies the actual organism. This test is more specific but can take several days to obtain a result. As a result, clinicians will often treat a bacteriuria based on the results of the urine dipstick test while waiting for the culture results. The culture will often provide antibiotic sensitivity.
Bacteriuria can be confirmed if a single bacterial species is isolated in a concentration greater than 100,000 colony forming units per millilitre of urine in clean-catch midstream urine specimens (one for men, two consecutive specimens with the same bacterium for women).[12] For urine collected via bladder catheterization in men and women, a single urine specimen with greater than 100,000 colony forming units of a single species per millilitre is considered diagnostic.[12] The threshold is also 100 colony forming units of a single species per millilitre for women displaying UTI symptoms.[13]
Screening
One time screening for bacteriuria is tentatively recommended during early pregnancy.[14]
Treatment
The decision to treat bacteriuria depends on the presence of accompany symptoms and comorbidities.
Asymptomatic bacteriuria
Asymptomatic bacteriuria generally does not require treatment.[4] Exceptions include during pregnancy and in those undergoing surgery of the urinary tract.[4][15] Children with vesicoureteral reflux or others with structural abnormalities of the urinary tract.[16][unreliable medical source?]
There is no indication to treat asymptomatic bacteriuria in diabetics, renal transplant recipients, and in those with spinal cord injuries.[17]
The overuse of antibiotic therapy to treat asymptomatic bacteriuria has many adverse effect[18] as it increases the risk of diarrhea, antimicrobial resistance, and infection due to Clostridium difficile. Other effects include increased financial burdens and overreporting of mandated catheter-associated urinary tract infection.
Symptomatic bacteriuria
Symptomatic bacteriuria is typically treated as a urinary tract infection with antibiotics. Common choices include nitrofurantoin, and trimethoprim/sulfamethoxazole.
Epidemiology
Rates of asymptomatic bacteriuria[5]
Group
Prevalence (in %)
Healthy premenopausal women
1.0 to 5.0
Pregnant women
1.9 to 9.5
Postmenopausal women (50 to 70 years of age)
2.8 to 8.6
People with diabetes mellitus
Women
9.0 to 27.0
Men
0.7 to 1.0
Older community-dwelling people
Women (older than 70 years)
> 15.0
Men
3.6 to 19.0
Older long-term care residents
Women
25.0 to 50.0
Men
15.0 to 40.0
People with spinal cord injury
Intermittent catheter
23.0 to 89.0
Sphincterotomy and condom catheter
57.0
People undergoing hemodialysis
28.0
People with an indwelling urinary catheter
Short-term
9.0 to 23.0
Long-term
100
References
^ abcdefDas, K. V. Krishna; Das, KV Krishna (2017). Textbook of Medicine: Two Volume Set. JP Medical Ltd. p. 1250. ISBN 9789386056108.
^ abSendi, P; Borens, O; Wahl, P; Clauss, M; Uçkay, I (2017). "Management of Asymptomatic Bacteriuria, Urinary Catheters and Symptomatic Urinary Tract Infections in Patients Undergoing Surgery for Joint Replacement: A Position Paper of the Expert Group". Journal of bone and joint infection. 2 (3): 154–159. doi:10.7150/jbji.20425. PMC 5592375. PMID 28894690.
^ abcdef"Bacterial Urinary Tract Infections (UTIs)". Merck Manuals Professional Edition. May 2016. Retrieved 12 December 2017.
^ abcdeKöves, B; Cai, T; Veeratterapillay, R; Pickard, R; Seisen, T; Lam, TB; Yuan, CY; Bruyere, F; Wagenlehner, F; Bartoletti, R; Geerlings, SE; Pilatz, A; Pradere, B; Hofmann, F; Bonkat, G; Wullt, B (25 July 2017). "Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel". European Urology. 72 (6): 865–868. doi:10.1016/j.eururo.2017.07.014. PMID 28754533.
^ abcdeColgan, R; Nicolle, LE; McGlone, A; Hooton, TM (15 September 2006). "Asymptomatic bacteriuria in adults". American Family Physician. 74 (6): 985–90. PMID 17002033.
^ abSalvatore S, Salvatore S, Cattoni E, Siesto G, Serati M, Sorice P, Torella M (June 2011). "Urinary tract infections in women". European journal of obstetrics, gynecology, and reproductive biology. 156 (2): 131–6. doi:10.1016/j.ejogrb.2011.01.028. PMID 21349630.
^ abNicolle LE (2008). "Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis". Urol Clin North Am. 35 (1): 1–12, v. doi:10.1016/j.ucl.2007.09.004. PMID 18061019.
^ abSchneeweiss J., Koch M., Umek W. (2016). "The human urinary microbiome and how it relates to urogynecology". Int Urogynecol J. 27 (9): 1307–12. doi:10.1007/s00192-016-2944-5. PMID 26811114.CS1 maint: Uses authors parameter (link)
^AMDA – The Society for Post-Acute and Long-Term Care Medicine (February 2014), "Ten Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, AMDA – The Society for Post-Acute and Long-Term Care Medicine, retrieved 20 April 2015
^Smaill, Fiona M.; Vazquez, Juan C. (2015-08-07). "Antibiotics for asymptomatic bacteriuria in pregnancy". The Cochrane Database of Systematic Reviews (8): CD000490. doi:10.1002/14651858.CD000490.pub3. ISSN 1469-493X. PMID 26252501.
^ abSzweda, Hanna; Jóźwik, Marcin (2016). "Urinary tract infections during pregnancy - an updated overview". Developmental Period Medicine. 20 (4): 263–272. ISSN 1428-345X. PMID 28216479.
^ abDetweiler K, Mayers D, Fletcher SG (November 2015). "Bacteruria and Urinary Tract Infections in the Elderly". The Urologic Clinics of North America (Review). 42 (4): 561–8. doi:10.1016/j.ucl.2015.07.002. PMID 26475952.
^Sam, Amir H.; James T.H. Teo (2010). Rapid Medicine. Wiley-Blackwell. ISBN 978-1-4051-8323-9.
^Moore, Ainsley; Doull, Marion; Grad, Roland; Groulx, Stéphane; Pottie, Kevin; Tonelli, Marcello; Courage, Susan; Garcia, Alejandra Jaramillo; Thombs, Brett D. (8 July 2018). "Recommendations on screening for asymptomatic bacteriuria in pregnancy". Canadian Medical Association Journal. 190 (27): E823–E830. doi:10.1503/cmaj.171325. PMID 29986858.
^Ramos, Jorge A.; Salinas, Diego F.; Osorio, Johanna; Ruano-Ravina, Alberto (September 2016). "Antibiotic prophylaxis and its appropriate timing for urological surgical procedures in patients with asymptomatic bacteriuria: A systematic review". Arab Journal of Urology. 14 (3): 234–239. doi:10.1016/j.aju.2016.05.002. ISSN 2090-598X. PMC 4983160. PMID 27547467.
^Asymptomatic bacteriuria from Medline Plus. Updated May 26, 2006, retrieved January 28, 2008.
^Nicolle, Lindsay E. (2014). "Urinary Tract Infections in Special Populations". Infectious Disease Clinics of North America. 28 (1): 91–104. doi:10.1016/j.idc.2013.09.006. PMID 24484577.
^Zalmanovici Trestioreanu, A; Lador, A; Sauerbrun-Cutler, MT; Leibovici, L (8 April 2015). "Antibiotics for asymptomatic bacteriuria". The Cochrane Database of Systematic Reviews. 4: CD009534. doi:10.1002/14651858.CD009534.pub2. PMID 25851268.
External links
Classification
D
External resources
MedlinePlus: 000520
v
t
e
Components and results of urine tests (CPT 81000–81099; R80–R82, 791)
Components
Albumin
Myoglobin
hCG
Leukocyte esterase
Urine pregnancy test
Ketone bodies
Glucose
Urobilinogen
Bilirubin
Creatinine
RBC
WBC
Urinary casts
Chemical properties
Urine specific gravity
Urine osmolality
Urine pH
Urine anion gap
Abnormal findings
Red blood cells
Hematuria (Microscopic hematuria)
White blood cells
Eosinophiluria
Proteinuria
Albuminuria/Microalbuminuria
Myoglobinuria
Hemoglobinuria
Small molecules
Glycosuria
Ketonuria
Bilirubinuria
Hyperuricosuria/Hypouricosuria
Aminoaciduria
Pathogens
Bacteriuria
Other
Chyluria
Crystalluria
osmolality (Isosthenuria, Hypersthenuria)
UpToDate Contents
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5. 乳児および1ヶ月以上の小児における尿路感染症：臨床的特徴および診断 urinary tract infections in infants and children older than one month clinical features and diagnosis
English Journal
The Development of Extremely Preterm Infants Born to Women Who Had Genitourinary Infections During Pregnancy.
Leviton A, Allred EN, Kuban KC, O'Shea TM, Paneth N, Onderdonk AB, Fichorova RN, Dammann O; ELGAN Study Investigators.
American journal of epidemiology.Am J Epidemiol.2016 Jan 1;183(1):28-35. doi: 10.1093/aje/kwv129. Epub 2015 Dec 13.
Gestational genitourinary infections, which have been associated with neurodevelopmental impairments among infants born near term, have not been studied among very preterm infants. The mothers of 989 infants born before 28 weeks of gestation were interviewed about urine, bladder, or kidney infection
Urethral (indwelling or intermittent) or suprapubic routes for short-term catheterisation in hospitalised adults.
Kidd EA1, Stewart F, Kassis NC, Hom E, Omar MI.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2015 Dec 10;12:CD004203. [Epub ahead of print]
BACKGROUND: Indwelling urethral catheters are often used for bladder drainage in hospital. Urinary tract infection is the most common hospital-acquired infection, and a common complication of urinary catheterisation. Pain, ease of use and quality of life are important to consider, as well as formal
Elizabethkingia meningoseptica as an Unusual Pathogen Causing Healthcare-associated Bacteriuria
Zong Zhiyong
Internal Medicine 53(16), 1877-1879, 2014
… meningoseptica bacteriuria were analyzed, and E. … meningoseptica was found to be the causative agent of healthcare-associated bacteriuria, including urinary tract infections, asymptomaticbacteriuria and transient bacteriuria, primarily in elderly patients with diabetes. … meningoseptica cultured from urine was found to be resistant to most antimicrobial agents, bacteriuria caused by E. …
INTRODUCTION The term asymptomatic bacteriuria refers to isolation of bacteria in an appropriately collected urine specimen from an individual without symptoms of urinary tract infection. Asymptomatic bacteriuria is common, but ...
Abstract Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America ...
