アシアロ糖タンパク質

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/18 21:54:06」(JST)

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If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.

The exposure of the subterminal galactose residues results in rapid clearance of the glycoproteins from the circulation through hepatocyte asialoglycoprotein receptors on Kuppfer cells.

External links

Asialoglycoproteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

The specificity and accuracy of (111)In-hexavalent lactoside in estimating liver reserve and its threshold value for mortality in mice.

Wang MH1, Chien CY2, Wang PY2, Yu HM2, Lee HS3, Lin WJ4.
Journal of hepatology.J Hepatol.2015 Aug;63(2):370-7. doi: 10.1016/j.jhep.2015.02.052. Epub 2015 Mar 19.
BACKGROUND & AIMS: The asialoglycoprotein receptor on hepatocyte membranes recognizes the galactose residues of glycoproteins. We investigated the specificity, accuracy and threshold value of asialoglycoprotein receptor imaging for estimating liver reserve via scintigraphy using (111)In-hexavale
PMID 25797863

Efficient Delivery of DOX to Nuclei of Hepatic Carcinoma Cells in the Subcutaneous Tumor Model Using pH-Sensitive Pullulan-DOX Conjugates.

Li H1, Cui Y2, Sui J2, Bian S2, Sun Y2, Liang J2, Fan Y2, Zhang X2.
ACS applied materials & interfaces.ACS Appl Mater Interfaces.2015 Jul 16. [Epub ahead of print]
A series of pullulan-doxorubicin conjugates (Pu-DOXs) were investigated for effectively delivering DOX to nuclei of hepatic carcinoma cells in subcutaneous tumor model. These Pu-DOXs were prepared by conjugating DOX onto pullulan molecule via pH-responsive hydrazone bond using spacers with different
PMID 26140410

Galactose-based Thermosensitive Nanogels for Targeted Drug Delivery of Iodoazomycin Arabinofuranoside (IAZA) for Theranostic Management of Hypoxic Hepatocellular Carcinoma.

Quan S1, Wang Y1, Zhou A, Kumar P, Narain R1.
Biomacromolecules.Biomacromolecules.2015 Jul 13;16(7):1978-86. doi: 10.1021/acs.biomac.5b00576. Epub 2015 Jun 3.
In this study, galactose-based nanogels were prepared by reversible addition-fragmentation chain transfer process to facilitate the targeted delivery of iodoazomycin arabinofuranoside (IAZA), a clinical drug for imaging solid hypoxic tumors, and evaluate its role in hypoxia-selective (radio)theranos
PMID 25996799

Japanese Journal

Galactose-Modified Cationic Liposomes as a Liver-Targeting Delivery System for Small Interfering RNA

Sonoke Satoru,Ueda Toshihiro,Fujiwara Kae [他],Kuwabara Kenji,Yano Junichi
Biological and Pharmaceutical Bulletin 34(8), 1338-1342, 2011
… The liposomes were designed to be transported into hepatocytes via the asialoglycoprotein receptor, which recognizes galactose residues. …
NAID 130000936610

siRNAのDDS : シクロデキストリン/デンドリマー結合体

有馬英俊,本山敬一
Drug delivery system 25(6), 598-606, 2010-11-25
これまで筆者らは，α-シクロデキストリン（α-CyD）とPAMAMデンドリマーとの結合体（α-CDE）は，デンドリマーのプロトンスポンジ効果に加えて，α-CyDのエンドソーム膜との相互作用に起因するエンドソーム脱出促進効果を有しており，遺伝子，siRNA，shRNA用キャリアとして有用であることを報告した．本稿ではα-CDEに細胞選択性を付与するために，種々の糖修飾α-CDEsや葉酸修飾α-CDE …
NAID 10027642911

Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/^<99m>Tc-GSA SPECT fusion images correlates well with postoperative liver function parameters

IIMURO Yuji,KASHIWAGI Toru,YAMANAKA Junichi,HIRANO Tadamichi,SAITO Shinichi,SUGIMOTO Takaaki,WATANABE Shinichiro,KURODA Nobukazu,OKADA Toshihiro,ASANO Yasukane,UYAMA Naoki,FUJIMOTO Jiro
Journal of hepato-biliary-pancreatic sciences 17(5), 673-681, 2010-09-01
NAID 10027663484