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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/26 12:18:39」(JST)

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In enzymology, an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an arylamine CoA + an N-acetylarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GX3, 1W5R, 1W6F, 2BSZ, 2IJA, 2PFR, and 2PQT.

References

CHOU TC, LIPMANN F (1952). "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 (1): 89–103. PMID 12980945.
Paul RC, Ratledge C (1973). "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 (1): 9–15. doi:10.1016/0304-4165(73)90160-8. PMID 4748369.
Tabor H, Mehler AH and Stadtman ER (1953). "The enzymatic acetylation of amines". J. Biol. Chem. 204 (1): 127–138. PMID 13084583.
Weissbach H, Redfield BG and Axelrod J (1961). "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta 54 (1): 190–192. doi:10.1016/0006-3002(61)90954-4. PMID 14005907.

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English Journal

Carbon Black Nanoparticles Impair Acetylation of Aromatic Amine Carcinogens through Inactivation of Arylamine N-Acetyltransferase Enzymes.

Sanfins E, Dairou J, Hussain S, Busi F, Chaffotte AF, Rodrigues-Lima F, Dupret JM.SourceUniv Paris Diderot, Sorbonne Paris Cite, Unite de Biologie Fonctionnelle et Adaptative, CNRS EAC4413, 75013, Paris, France.
ACS nano.2011 May 3. [Epub ahead of print]
Carbon black nanoparticles (CB NPs) and their respirable aggregates/agglomerates are classified as possibly carcinogenic to humans. In certain industrial work settings, CB NPs coexist with aromatic amines (AA), which comprise a major class of human carcinogens. It is therefore crucial to characteriz
PMID 21526848

Liver-Selective Expression of Human Arylamine N-Acetyltransferase NAT2 in Transgenic Mice.

Sugamori KS, Brenneman D, Grant DM.SourceDepartment of Pharmacology and Toxicology, University of Toronto, Room 4316 Medical Sciences Building, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. denis.grant@utoronto.ca.
Drug metabolism and disposition: the biological fate of chemicals.2011 May;39(5):882-90. Epub 2011 Feb 11.
Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominantly in liver. Interspecies differences and incongruous results between in vitro, in vivo, and epidem
PMID 21317369

Japanese Journal

Gene cloning and characterization of arylamine N-acetyltransferase from Bacillus cereus strain 10-L-2(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Takenaka Shinji,Cheng Minyi,Mulyono,Koshiya Atsushi,Murakami Shuichiro,Aoki Kenji
Journal of bioscience and bioengineering 107(1), 27-32, 2009-01
… Bacillus cereus strain 10-L-2 synthesizes two arylamine N-acetyltransferases (Nat-a and Nat-b) with broad substrate specificities toward aniline and its derivatives. … In southern blot analysis using probes encoding the NH_2-terminus of Nat-b and a conserved region of N-acetyltransferases, digested total DNA of strain 10-L-2 showed one positive band. …
NAID 110007042020

Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population : proposal for a new nomenclature

YULIWULANDARI Rika,SACHROWARDI Qomariyah,NISHIDA Nao,TAKASU Miwa,BATUBARA Lilian,SUSMIARSIH Tri Panjiasih,ROCHANI Jecti Teguh,WIKANINGRUM Riyani,MIYASHITA Risa,MIYAGAWA Taku,SOFRO Abdul Salam Mudzakir,TOKUNAGA Katsushi
Journal of human genetics 53(3), 201-209, 2008-03-01
NAID 10021248101

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★リンクテーブル★

リンク元	「アリールアミンN-アセチルトランスフェラーゼ」「アリールアミン-N-アセチルトランスフェラーゼ」
関連記事	「acetyltransferase」「n」「N」「Nd」

「アリールアミンN-アセチルトランスフェラーゼ」

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arylamine N-acetyltransferase
Identifiers
EC number	2.3.1.5
CAS number	9027-33-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
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PMC	articles
PubMed	articles
NCBI	proteins