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English Journal

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.

Jiang Y1, Pan Y1, Rhea PR1, Tan L1, Gagea M2, Cohen L1, Fischer SM3, Yang P4.
Cancer research.Cancer Res.2016 Jan 1;76(1):24-9. doi: 10.1158/0008-5472.CAN-14-3432.
Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor dev
PMID 26729790

A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesis.

Teng CF1, Hsieh WC1, Yang CW2, Su HM3, Tsai TF4,5, Sung WC1, Huang W6, Su IJ1,2.
Molecular carcinogenesis.Mol Carcinog.2016 Jan;55(1):105-14. doi: 10.1002/mc.22266. Epub 2015 Jan 15.
Metabolic syndrome has closely linked to the development of human hepatocellular carcinoma (HCC). By using the hepatitis B virus (HBV) X (HBx) transgenic mouse model, we studied the dynamic evolution of serum and liver profiles of lipids and global cDNA expression at different stages of HBx tumorige
PMID 25594851

Kumar A1, Kumar P, Kathuria P, Misra S, Pandit AK, Chakravarty K, Prasad M.
Neurology India.Neurol India.2016 Jan-Feb;64(1):29-37. doi: 10.4103/0028-3886.173645.
Stroke, a heterogeneous multifactorial disorder, is known to be a major cause of death and adult disability within both the developed and developing countries. Approximately 85% of stroke cases are ischemic, whereas the remaining 15% are hemorrhagic. It is caused by multiple genetic factors, environ
PMID 26754989

Expression Analysis of Leukotriene-Inflammatory Gene Interaction Network in Patients with Coronary Artery Disease

Nair Jiny,Shanker Jayashree,Jambunathan Srikarthika,Arvind Prathima,Kakkar Vijay V
Journal of Atherosclerosis and Thrombosis 21(4), 329-345, 2014
… Four single nucleotide polymorphisms(SNPs) (rs6538697, rs2660898, rs17525495 and rs1978331) in the leukotriene A4 hydrolase(LTA4H) gene were genotyped using SYBR green method, and plasma leukotriene B4(LTB4) levels were measured using ELISA.Results: The expression levels of arachidonate 5-lipoxygenase(ALOX5), LTA4H, tumor necrosis factor(TNF) and interleukin-8 (IL-8) genes were significantly higher in patients than in the controls(p＜0.05). …
NAID 130004444722

Preliminary assessment of differential expression of candidate genes associated with atherosclerosis

Blin Joan,Ahmad Zalinah,Rampal Lekhraj [他],Mohtarrudin Norhafizah,Tajudin Abdul Karim Haji,Adnan Rohayu Shahar
Genes & Genetic Systems 88(3), 199-209, 2013
… study was aimed at assessing the expression levels of 11 candidate genes, namely tumor protein (TP53), transforming growth factor, beta receptor II (TGFBR2), cysthathionenine-beta-synthase (CBS), insulin receptor substrate 1 (IRS1), lipoprotein lipase (LPL), methylenetetrahydrofolate reductase (MTHFR), thrombomodulin (THBD), lecithin-cholesterol acyltransferase (LCAT), matrix metallopeptidase 9 (MMP9), low density lipoprotein receptor (LDLR), and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) genes associated with …
NAID 130003361009