WordNet

arrange (open windows) on a computer desktop so that they overlap each other, with the title bars visible
a small waterfall or series of small waterfalls
a succession of stages or operations or processes or units; "progressing in severity as though a cascade of genetic damage was occurring"; "separation of isotopes by a cascade of processes"
rush down in big quantities, like a cascade (同)cascade down

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A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood.

Ren R, Hashimoto T, Mizuno M, Takigawa H, Yoshida M, Azuma T, Kanazawa K.SourceDepartment of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.
Journal of clinical biochemistry and nutrition.J Clin Biochem Nutr.2013 May;52(3):228-33. doi: 10.3164/jcbn.12-110. Epub 2013 May 1.
Lipid peroxidation products are known to cause toxicity by reacting with biologically significant proteins, but the inducing role of peroxidation products has been not noted to produce degenerative disease-related eicosanoids. Here, 9-oxononanoic acid (9-ONA), one of the major products of peroxidize
PMID 23704812

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.

Meirer K, Rödl CB, Wisniewska JM, George S, Häfner AK, Buscató EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E.SourceInstitute of Pharmaceutical Chemistry, ZAFES/LiFF/OSF, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany.
Journal of medicinal chemistry.J Med Chem.2013 Feb 28;56(4):1777-81. doi: 10.1021/jm301617j. Epub 2013 Feb 7.
Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety concerns. Administration of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side effects. We therefore
PMID 23356879

Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction.

Bishayee K, Chakraborty D, Ghosh S, Boujedaini N, Khuda-Bukhsh AR.SourceCytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India.
European journal of pharmacology.Eur J Pharmacol.2013 Jan 5;698(1-3):110-21. doi: 10.1016/j.ejphar.2012.10.041. Epub 2012 Nov 6.
When the prostate cancer cells become unresponsive to androgen therapy, resistance to chemotherapy becomes imminent, resulting in high mortality. To combat this situation, lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatum spores, was tested against hormon
PMID 23142370

二宮宣文,根本香代,久野将宗
日本救急医学会雑誌 23(8), 333-341, 2012
我々は敗血症の病態の理解および治療に関連する基礎実験を行っている。Lipopolysaccharide（LPS）に対する個体の反応性と実験手技の簡便性の観点から，モルモットのエンドトキシン血症モデルを用いている。我々はとくにLPS投与後に腸管麻痺が起こることに着目した。モルモットエンドトキシン血症モデルでは，LPS刺激後2-3時間で腸管弛緩反応のピークが観察される。この2-3時間に至る間にモルモッ …
NAID 130004542334