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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/13 06:15:20」(JST)

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Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.^[3] In the kidney, AQP3 is regulated by vasopressin (ADH).^[4] This protein is also a determinant for the GIL blood group system.^[5]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.
^ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – via Elsevier.
^ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222.

External links

GIL blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
Human AQP3 genome location and AQP3 gene details page in the UCSC Genome Browser.

UpToDate Contents

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1. 羊水量調節の生理学 physiology of amniotic fluid volume regulation
2. 赤血球細胞膜：構造、機構、動態 red blood cell membrane structure organization and dynamics
3. 腹膜透析における溶質クリアランスおよび限外濾過の機序 mechanisms of solute clearance and ultrafiltration in peritoneal dialysis
4. 羊水過少 oligohydramnios

English Journal

Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3.

Wu Z1, Uchi H2, Morino-Koga S3, Shi W4, Furue M5.
Journal of dermatological science.J Dermatol Sci.2014 Jul;75(1):16-23. doi: 10.1016/j.jdermsci.2014.03.004. Epub 2014 Mar 25.
BACKGROUND: Aquaporin 3 (AQP3) is the predominant aquaporin in the skin and is overexpressed in hyperplastic epidermal disorders. Upregulation of AQP3 contributes to keratinocyte proliferation and epidermal hyperplasia. Resveratrol, a natural polyphenol, has an anti-proliferative effect on normal hu
PMID 24726500

Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.

Chaudhuri RK1, Bojanowski K.
International journal of cosmetic science.Int J Cosmet Sci.2014 Jun;36(3):221-30. doi: 10.1111/ics.12117. Epub 2014 Mar 6.
OBJECTIVE: The study was undertaken to compare the skin care related activities of retinol and bakuchiol, a potential alternative to retinoids. Retinol is a pivotal regulator of differentiation and growth of developing as well as adult skin. Retinoic acid is the major physiologically active metaboli
PMID 24471735

miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.

Jiang B1, Li Z, Zhang W, Wang H, Zhi X, Feng J, Chen Z, Zhu Y, Yang L, Xu H, Xu Z.
Journal of gastroenterology.J Gastroenterol.2014 Jun;49(6):1011-25. doi: 10.1007/s00535-013-0851-9. Epub 2013 Jun 26.
BACKGROUND: Aquaporin-3 (AQP3) is a water transporting protein which plays an oncogenic role in several malignant tumors. However, its regulatory mechanism remains elusive to date. In this study, we investigated the microRNA-mediated gene repression mechanism involved in AQP3's role.METHODS: The pot
PMID 23800944

Japanese Journal

Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis

PLoS ONE 12(2), e0171880, 2017-02-15
NAID 120005997131

Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

PLOS ONE 12(2), 2017-02-07
NAID 120005980864

血液脳関門障害の機序解明から血管性認知症の予防と治療に向けて

臨床神経学 57(3), 95-109, 2017
NAID 130005494231

Related Pictures

★リンクテーブル★

リンク元	「アクアポリン3」「AQP3」

「アクアポリン3」

AQP3
Identifiers
Aliases	AQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
External IDs	OMIM: 600170 MGI: 1333777 HomoloGene: 21025 GeneCards: AQP3
Gene ontology
Molecular function	• transporter activity; • water channel activity; • glycerol channel activity;
Cellular component	• cytoplasm; • integral component of membrane; • membrane; • cell-cell junction; • plasma membrane; • basolateral plasma membrane; • nucleus;
Biological process	• positive regulation of immune system process; • excretion; • response to vitamin D; • response to retinoic acid; • water transport; • urea transport; • odontogenesis; • response to calcium ion; • renal water homeostasis; • transport; • regulation of keratinocyte differentiation; • renal water absorption; • glycerol transport; • cellular response to oxygen-glucose deprivation; • cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	360
	11828
	ENSG00000165272
	ENSMUSG00000028435
	Q92482
	Q8R2N1
	NM_004925; NM_001318144
	NM_016689
	NP_001305073; NP_004916
	NP_057898.2; NP_057898
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: aquaporin 3、AQP3
同: アクアポリン-3、水チャネルアクアポリン-3
関: アクアポリン

主に腎集合管の側底膜に存在する水チャネル

「AQP3」

　　[★] アクアポリン3 aquaporin 3

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[pmid9558461-3] Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.

[pmid9824541-4] Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – via Elsevier.

[pmid12239222-5] Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222.

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案内

aquaporin 3