aprobarbital

アプロバルビタール

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/29 21:24:05」(JST)

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Aprobarbital

Systematic (IUPAC) name
5-propan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Identifiers
CAS Registry Number	77-02-1 Y
ATC code	N05CA05
PubChem	CID 6464
DrugBank	DB01352 Y
ChemSpider	6221 Y
UNII	Q0YKG9L6RF Y
KEGG	D00698 Y
ChEBI	CHEBI:2791 Y
ChEMBL	CHEMBL7863 Y
Synonyms	aprobarbital, Oramon, allylpropymal, Alurate, 5-isopropyl- 5-allylbarbituric acid
Chemical data
Formula	C10H14N2O3
Molecular mass	210.23 g/mol
SMILES O=C1NC(=O)NC(=O)C1(C(C)C)C\C=C
InChI InChI=1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)  Y Key:UORJNBVJVRLXMQ-UHFFFAOYSA-N  Y
Y (what is this?)  (verify)

Aprobarbital (as known in the United States, or aprobarbitone (as known elsewhere), sold as Oramon, Somnifaine, and Allonal, is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia. Aprobarbital was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed as it has been replaced by newer drugs with a better safety margin.

References

English Journal

• Occurrence and fate of barbiturates in the aquatic environment.

• Peschka M, Eubeler JP, Knepper TP.SourceEuropa University of Applied Sciences Fresenius, Limburger Strasse 2, D-65510 Idstein, Germany.
• Environmental science & technology.Environ Sci Technol.2006 Dec 1;40(23):7200-6.
• Barbiturates have been widely used as sedative hypnotics in the mid-1960s and since then mainly as veterinary drugs. To monitor their presence and fate in the aquatic environment, a method based on gas chromatography-mass spectrometry (GC-MS) has been developed to quantify butalbital, secobarbital,
• PMID 17180967

• Determinations of zidovudine/didanosine/nevirapine and zidovudine/didanosine/ritonavir in human serum by micellar electrokinetic chromatography.

• Fan B, Stewart JT.SourceDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, 30602-2352, Athens, GA, USA.
• Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2002 Nov 7;30(4):955-60.
• Micellar electrokinetic chromatography methods were developed and validated to separate and quantitate anti-HIV drug mixtures containing zidovudine(AZT)/didanosine(ddI)/nevirapine (mixture A) and AZT/ddI/ritonavir (mixture B) in human serum. Serum samples were prepared using a solid-phase extraction
• PMID 12408885

Japanese Journal

• Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital,aprobarbital, pentabarbital, secobarbital and 5-phenyl and 5-ethylbarbituric acids.

• RICE J. M.
• Carcinogenesis 15, 395-402, 1994
• NAID 80007473665

Related Links

• Aprobarbital - Wikipedia, the free encyclopedia

Aprobarbital (Oramon) is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia. Aprobarbital was never as widely ...

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アリルイソプロピルマロニル尿素 allyl isopropyl malonyl urea