ア・リ・タンパク質E3

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Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice.

Dolejší E1, Liraz O2, Rudajev V1, Zimčík P1, Doležal V1, Michaelson DM2.
Journal of neurochemistry.J Neurochem.2016 Feb;136(3):503-9. doi: 10.1111/jnc.13417. Epub 2015 Nov 19.
Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease. We utilized apoE4-targeted replacement mice (approved by the Tel Aviv University Animal Care Committee) to investigate whether cholinergic dysfunction, which increases during aging and is a hallmark of Alzhe
PMID 26526158

Identification of novel therapeutic targets in the secretome of ionizing radiation‑induced senescent tumor cells.

Hwang HJ1, Jung SH1, Lee HC1, Han NK2, Bae IH2, Lee M2, Han YH2, Kang YS3, Lee SJ4, Park HJ5, Ko YG6, Lee JS1.
Oncology reports.Oncol Rep.2016 Feb;35(2):841-50. doi: 10.3892/or.2015.4473. Epub 2015 Dec 2.
Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF locus and DNA damage. Senescence has been considered a tumor‑suppressing mechanism that permanently arrests cells
PMID 26717900

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease.

El-Lebedy D1, Raslan HM2, Mohammed AM3.
Cardiovascular diabetology.Cardiovasc Diabetol.2016 Jan 22;15(1):12. doi: 10.1186/s12933-016-0329-1.
BACKGROUND: Lipoprotein-related mechanisms have been associated with damage to the cardiovascular system in diabetic patients. Apolipoprotein E gene which affects the clearance of lipoproteins and consequently the lipid profile in our body is one of the most studied candidate genes and recently has
PMID 26800892