アポクリン化生
WordNet
- (of exocrine glands) producing a secretion in which part of the secreting cell is released with the secretion; "mothers milk is one apocrine secretion"
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/02 20:46:05」(JST)
[Wiki en表示]
| Exocrine Secretion
|
| Merocrine or eccrine – by exocytosis |
| Apocrine – by membrane budding (loss of cytoplasm) |
| Holocrine – by membrane rupture |
Apocrine is a term used to classify exocrine glands in the study of histology. Cells which are classified as apocrine bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen.The apical portion of the secretory cell of the gland pinches off and enters the lumen. It loses part of its cytoplasm in their secretions. Apocrine glands are found around armpits & the nipples and the groin regions of the body. Apocrine is functional during hormonal stress or puberty.
Secretion occurs when the release of secretory materials is accompanied with loss of part of cytoplasm. Apocrine secretion is less damaging to the gland than holocrine secretion (which destroys a cell) but more damaging than merocrine secretion (exocytosis). An example of true apocrine glands are mammary glands, responsible for secreting breast milk.[1]
Contents
- 1 Apocrine Metaplasia
- 2 Apocrine Carcinoma
- 3 References
- 4 External links
Apocrine Metaplasia
Main article: Metaplasia
Apocrine Metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in the breast in the context of fibrocystic change.It is seen in women mostly over the age of 50 years. Metaplasia happens when there is an irritation to the breast(breast cyst). Apocrine-like cells form in a lining of developing microcysts, due to the pressure buildup within the lumen. The pressure build up is caused by secretions.[2] The chance of developing breast cancer increases when metaplasia proliferates.
Apocrine Carcinoma
Apocrine Carcinoma is a very rare form of female breast cancer. The rate of incidence varies from 0.5 to 4%.[3] Cytologically, the cells of apocrine carcinoma are relatively large, granular, and it has a prominent eosinophilic cytoplasm.[4] When Apocrine Carcinoma is tested as a “triple negative”, it means that the cells of the victim cannot express the estrogen receptor, progesterone receptor, or HER2 receptor.[5]
References
- ^ Mescher AL, "Chapter 4. Epithelial Tissue" (Chapter). Mescher AL: Junqueira's Basic Histology: Text & Atlas, 12e: http://www.accessmedicine.com/content.aspx?aID=6180489.
- ^ Dr Ayush Goel and Radswiki et al. Apocrine metaplasia of the breast.http://radiopaedia.org/articles/apocrine-metaplasia-of-the-breast
- ^ Khandeparkar, Siddhi Gaurish Sinai, Sanjay D. Deshmukh, and Pallavi D. Bhayekar. "A rare case of apocrine carcinoma of the breast: Cytopathological and immunohistopathological study." Journal of Cytology/Indian Academy of Cytologists 31.2 (2014): 96.
- ^ http://path.upmc.edu/cases/case209/dx.html (accessed November 3, 2014)
- ^ http://www.hopkinsmedicine.org/kimmel_cancer_center/centers/breast_cancer_program/rare_tumors/apocrine_breast_cancer (accessed October 28, 2014)
External links
- 1624244281 at GPnotebook
- Diagram at uwa.edu.au
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Epithelial tissue
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| Cells |
- Columnar
- Cuboidal
- Squamous
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| Types |
- Simple squamous epithelium
- Simple cuboidal epithelium
- Simple columnar epithelium
- Pseudostratified columnar epithelium
- Stratified squamous epithelium
- Stratified cuboidal epithelium
- Stratified columnar epithelium
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| Glandular |
| Classification |
| Mechanism |
- Merocrine
- Apocrine
- Holocrine
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| Shape |
- Tubular gland
- Alveolar gland
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| Secretion |
- Serous glands
- Mucous glands
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| Components |
- Myoepithelial cell
- Serous demilune
- Ducts:
- Interlobar
- Interlobular
- Intralobular
- Striated
- Intercalated
- Acinus/Lobe
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|
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- See also
- Template:Epithelial neoplasms
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UpToDate Contents
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English Journal
- Neuroendocrine tumor cells in prostate cancer: evaluation of the neurosecretory products serotonin, bombesin, and gastrin - impact on angiogenesis and clinical follow-up.
- Heinrich E, Trojan L, Friedrich D, Voss M, Weiss C, Michel MS, Grobholz R.SourceDepartment of Urology, University Hospital Mannheim, Mannheim, Germany.
- The Prostate.Prostate.2011 Dec;71(16):1752-8. doi: 10.1002/pros.21392. Epub 2011 Apr 7.
- BACKGROUND: Neuroendocrine differentiated tumor cells (NETC) can be found in a large portion of prostate carcinoma (PCa) specimens. This is the first study to systematically quantify and analyze the influence of the NETC distribution and of their secretory products, serotonin, bombesin, and gastrin,
- PMID 21480309
- Cervical-type squamous metaplasia and myoepithelial cell differentiation in stromal tumor of the prostate.
- Montironi R, Lopez-Beltran A, Cheng L, Scarpelli M.
- The American journal of surgical pathology.Am J Surg Pathol.2011 Nov;35(11):1752-4.
- PMID 21989353
- Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity.
- Simanainen U, McNamara K, Gao YR, McPherson S, Desai R, Jimenez M, Handelsman DJ.SourceANZAC Research Institute, University of Sydney, NSW, Australia.
- American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2011 Oct;301(4):E727-35. Epub 2011 Jul 12.
- Androgens influence prostate growth and development, so androgen withdrawal can control progression of prostate diseases. Although estrogen treatment was originally used to induce androgen withdrawal, more recently direct estrogen effects on the prostate have been recognized, but the nature of andro
- PMID 21750267
Japanese Journal
- <b>A Histopathological Study of Mucous Cyst of the Maxillary Sinus </b>
- International Journal of Oral-Medical Sciences 11(3), 163-171, 2013
- NAID 130003375169
Related Links
- Apocrine metaplasia, a common surprise on a breast biopsy report, luckily it is benign and does not become cancer. ... Instead, Apocrine metaplasia is named according to the shape of the new cells, which have a visual ...
- Apocrine metaplasia of the breast is a benign breast condition and is sometimes considered part of or associated with fibrocystic change. It is a common finding in the female breast particularly after the age of 25 and many regard it ...
★リンクテーブル★
[★]
- 英
- apocrine metaplasia
- 関
- 化生、乳腺症
- 2008/12/16 内分泌 病理 (breast_patology.ppt)
病理
- あぽくりんかんせんとおなじそしきぞうに化生する
- ひじょうにあかみがつよいのがとくちょう
- 弾道分泌 うちがわに飛び出している
[★]
- Reversible change in which one adult cell type (epithelial or mesenchymal) is replaced by another adult cell type