apocrine gland carcinoma

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/30 11:19:08」(JST)

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英文文献

  • Cutaneous and mammary apocrine carcinomas have different immunoprofiles.
  • Piris A1, Peng Y2, Boussahmain C3, Essary LR4, Gudewicz TM1, Hoang MP5.Author information 1Department of Pathology, Massachusetts General Hospital, Boston, MA 02114; Department of Pathology, Harvard Medical School, Boston, MA 02114.2Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235.3Department of Pathology, Massachusetts General Hospital, Boston, MA 02114.4Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75235.5Department of Pathology, Massachusetts General Hospital, Boston, MA 02114; Department of Pathology, Harvard Medical School, Boston, MA 02114. Electronic address: mhoang@partners.org.AbstractOften the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6, p63, GATA3, mammaglobin, androgen receptor, estrogen receptor, progesterone receptor, and HER2 by immunohistochemistry in 14 cutaneous apocrine carcinomas (11 primary tumors, 3 metastases) and 26 primary apocrine carcinomas of the breast. Whereas focal adipophilin staining was seen in 36% (5/14) of cutaneous apocrine carcinoma, strong and diffuse adipophilin staining was seen in 88% (22/25) of mammary apocrine carcinoma (P = .0013). Differences in estrogen receptor and progesterone receptor expression were also statistically significant (P = .018 and .043). Androgen receptor was strongly positive in all cutaneous and mammary cases. Although there was no significant difference in the frequency of expression of cytokeratin 5/6, p63, HER2, GATA3, and mammaglobin in cutaneous apocrine carcinoma versus mammary apocrine carcinoma, strong and diffuse cytokeratin 5/6 and/or mammaglobin expression were seen only in cutaneous apocrine carcinoma. In conclusion, cutaneous apocrine carcinoma is likely adipophilin- ER+ PR+/- HER2- and can exhibit strong and diffuse cytokeratin 5/6 and/or mammaglobin expression. On the contrary, a mammary apocrine carcinoma is likely adipophilin+ ER- PR- and often exhibit 3+ HER2 with corresponding HER2 gene amplification. A panel of adipophilin, ER, PR, HER2, cytokeratin 5/6, and mammaglobin may be helpful in distinguishing cutaneous apocrine carcinoma from mammary apocrine carcinoma.
  • Human pathology.Hum Pathol.2014 Feb;45(2):320-6. doi: 10.1016/j.humpath.2013.09.007. Epub 2013 Dec 14.
  • Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6,
  • PMID 24342430
  • Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon.
  • Lee OJ1, Yun SJ2, Kim WJ2, Choi SY1, Lee HC1, Song HG1, Lim SN3, Lee KH3, Kim ST3, Han HS3.Author information 1Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.2Department of Urology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.3Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.AbstractApocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget's disease (EMPD) associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin (H&E) staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.
  • Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.Chin J Cancer Res.2013 Dec;25(6):777-80. doi: 10.3978/j.issn.1000-9604.2013.12.11.
  • Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-o
  • PMID 24385708

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関連リンク

This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog. A 7-year-old male terrier dog was referred to small animal hospital of Shahid Bahonar 1. ...
carcinoma of an apocrine gland. 2. a rare breast malignancy with a ductal or acinar growth pattern and apocrine secretions. basal cell carcinoma an epithelial tumor of the skin that seldom metastasizes but has the potential for ...

関連画像

APOCRINE GLAND ADENOCARCINOMA IN DOGSApocrine sweat gland carcinomaApocrine carcinomaApocrine gland carcinoma, papillary type


★リンクテーブル★
リンク元アポクリン腺癌
関連記事gland」「carcinoma」「apocrine」「gla

アポクリン腺癌」

  [★]

apocrine gland carcinoma
アポクリン汗腺腫瘍


gland」

  [★]

WordNet   license wordnet

「any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream」
secretory organ, secretor, secreter

PrepTutorEJDIC   license prepejdic

「(生物体内の)腺(せん)」


carcinoma」

  [★]

WordNet   license wordnet

「any malignant tumor derived from epithelial tissue; one of the four major types of cancer」

PrepTutorEJDIC   license prepejdic

「がん,がん腫」


apocrine」

  [★] アポクリン

WordNet   license wordnet

「(of exocrine glands) producing a secretion in which part of the secreting cell is released with the secretion; "mother''s milk is one apocrine secretion"」

gla」

  [★]

γ-carboxyglutamate




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