WordNet
- an unstable situation of extreme danger or difficulty; "they went bankrupt during the economic crisis"
- a crucial stage or turning point in the course of something; "after the crisis the patient either dies or gets better"
PrepTutorEJDIC
- (社会上・政治上の)『重大な事態』,『難局』,危機 / (人生の)重大な転機(岐路),重大事 / 最悪状態
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/05/15 13:30:31」(JST)
[Wiki en表示]
| Reticulocytopenia |
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| Other names | Aplastic crisis, Marrow failure |
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Reticulocytopenia, is the medical term for an abnormal decrease of reticulocytes in the body. Reticulocytes are new, immature red blood cells.
Causes
Reticulocytopenia is usually a result of viral parvovirus B19 infection, which invades and destroys red blood cell precursors and halts the red cell production.
If infection occurs in individuals with sickle cell anemia,[1] spherocytosis, or beta thalassemia, it will lead to incorporation of two anemia-induced mechanisms: decreased red cell production and hemolysis. The result is a rapid and severe anemia (aplastic crisis) which may require blood transfusion.
See also
- Erythropoiesis – process of creating red blood cells
- Hemolytic anemia – reduced number of red blood cells due to destruction of the cells after they were made
- Nutritional anemia – reduced number of red blood cells due to vitamin deficiency or other dietary factors
References
- ^ "Sickle Cell Disease - Basic Principles and Clinical Practice" Edited by Stephen H. Embury, Robert P. Hebbel, Narla Mohandas and Martin Steinberg. Copyright 1996 by Lippincott-Raven. Section IV p352.
External links
| Classification | D - ICD-9-CM: 282.62
- DiseasesDB: 10703
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Infectious diseases – viral systemic diseases (A80–B34, 042–079) |
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| Oncovirus |
- DNA virus
- HBV
- Hepatocellular carcinoma
- HPV
- Cervical cancer
- Anal cancer
- Penile cancer
- Vulvar cancer
- Vaginal cancer
- Oropharyngeal cancer
- KSHV
- Kaposi's sarcoma
- EBV
- Nasopharynx cancer
- Burkitt's lymphoma
- Hodgkin's lymphoma
- Follicular dendritic cell sarcoma
- Extranodal NK/T-cell lymphoma, nasal type
- MCPyV
- Merkel-cell carcinoma
- RNA virus
- HCV
- Hepatocellular carcinoma
- Splenic marginal zone lymphoma
- HTLV-I
- Adult T-cell leukemia/lymphoma
|
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| Immune disorders | |
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Central
nervous system | Encephalitis/
meningitis |
- DNA virus
- JCV
- Progressive multifocal leukoencephalopathy
- RNA virus
- MeV
- Subacute sclerosing panencephalitis
- LCV
- Lymphocytic choriomeningitis
- Arbovirus encephalitis
- Orthomyxoviridae (probable)
- Encephalitis lethargica
- RV
- Rabies
- Chandipura virus
- Herpesviral meningitis
- Ramsay Hunt syndrome type 2
|
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| Myelitis |
- Poliovirus
- Poliomyelitis
- Post-polio syndrome
- HTLV-I
- Tropical spastic paraparesis
|
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| Eye |
- Cytomegalovirus
- Cytomegalovirus retinitis
- HSV
|
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|
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| Cardiovascular | |
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Respiratory system/
acute viral nasopharyngitis/
viral pneumonia | | DNA virus |
- Epstein–Barr virus
- EBV infection/Infectious mononucleosis
- Cytomegalovirus
|
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| RNA virus |
- IV: SARS coronavirus
- Severe acute respiratory syndrome
- V: Orthomyxoviridae: Influenzavirus A/B/C/D
- Influenza/Avian influenza
- V, Paramyxoviridae: Human parainfluenza viruses
- RSV
- hMPV
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|
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| Human digestive system | | Pharynx/Esophagus |
- MuV
- Cytomegalovirus
- Cytomegalovirus esophagitis
|
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Gastroenteritis/
diarrhea |
- DNA virus
- Adenovirus
- Adenovirus infection
- RNA virus
- Rotavirus
- Norovirus
- Astrovirus
- Coronavirus
|
|---|
| Hepatitis |
- DNA virus
- HBV (B)
- RNA virus
- CBV
- HAV (A)
- HCV (C)
- HDV (D)
- HEV (E)
- HGV (G)
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| Pancreatitis | |
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| Urogenital | |
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Diseases of red blood cells (D50–69,74, 280–287) |
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| ↑ | |
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| ↓ | | Anemia | | Nutritional |
- Micro-: Iron-deficiency anemia
- Macro-: Megaloblastic anemia
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Hemolytic
(mostly normo-) | | Hereditary |
- enzymopathy: Glucose-6-phosphate dehydrogenase deficiency
- glycolysis
- pyruvate kinase deficiency
- triosephosphate isomerase deficiency
- hexokinase deficiency
- hemoglobinopathy: Thalassemia
- Sickle-cell disease/trait
- Hereditary persistence of fetal hemoglobin
- membrane: Hereditary spherocytosis
- Minkowski–Chauffard syndrome
- Hereditary elliptocytosis
- Southeast Asian ovalocytosis
- Hereditary stomatocytosis
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| Acquired | | AIHA |
- Warm autoimmune hemolytic anemia
- Cold agglutinin disease
- Primary cold agglutinin disease
- Secondary cold agglutinin syndrome
- Donath–Landsteiner hemolytic anemia
- Paroxysmal cold hemoglobinuria
- Mixed autoimmune hemolytic anemia
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- membrane
- paroxysmal nocturnal hemoglobinuria
- Microangiopathic hemolytic anemia
- Thrombotic microangiopathy
- Hemolytic-uremic syndrome
- Drug-induced autoimmune
- Drug-induced nonautoimmune
- Hemolytic disease of the newborn
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Aplastic
(mostly normo-) |
Hereditary: Fanconi anemia
Diamond–Blackfan anemia
- Acquired: Pure red cell aplasia
- Sideroblastic anemia
- Myelophthisic
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| Blood tests |
- Mean corpuscular volume
- normocytic
- microcytic
- macrocytic
- Mean corpuscular hemoglobin concentration
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| Other |
- Methemoglobinemia
- Sulfhemoglobinemia
- Reticulocytopenia
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UpToDate Contents
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- 1. 鎌状赤血球症の臨床症状の概要overview of the clinical manifestations of sickle cell disease [show details]
…SCD include the following : Infections – Severe anemia (eg, due to splenic sequestration, aplastic crisis, or hyperhemolysis) – Vaso-occlusive phenomena; Acute vaso-occlusive pain – Stroke – …
- 2. パルボウイルスB19感染の臨床症状および診断clinical manifestations and diagnosis of parvovirus b19 infection [show details]
… evidence of seroconversion to parvovirus B19, with 67 percent of those individuals experiencing aplastic crisis. Patients with TAC usually present with pallor, weakness, and lethargy secondary to severe anemia …
- 3. パルボウイルスB19感染の治療および予防treatment and prevention of parvovirus b19 infection [show details]
…that can occur with B19 infection include: Erythema infectiosum; Arthritis or arthralgia; Transient aplastic crisis; Fetal hydrops; Chronic infection with or without anemia; The major issues related to the …
- 4. 遺伝性球状赤血球症hereditary spherocytosis [show details]
… required in severely affected infants and may be needed during certain times in other settings (eg, aplastic crisis, pregnancy). However, transfusions usually are not required on a chronic basis or for a long …
- 5. 小児における赤血球産生低下による貧血anemia in children due to decreased red blood cell production [show details]
…results in erythema infectiosum (fifth disease) in childhood . The virus has been associated with aplastic crisis in patients with hemolytic anemias, prolonged red cell aplasia and chronic anemias in patients…
English Journal
- [Aplastic crisis due to Parvovirus B19 and Epstein-Barr virus in a patient with hereditary spherocytosis].
- Leoz Gordillo I1, Pérez Suárez E2.
- Anales de pediatría (Barcelona, Spain : 2003).An Pediatr (Barc).2015 Jan;82(1):e102-7. doi: 10.1016/j.anpedi.2013.12.014. Epub 2014 Mar 12.
- Anemic syndrome in childhood requires a diagnosis and urgent treatment guided by systematic protocols that can avoid unnecessary additional testing. The case of a 4 year-old girl with fatigue and intermittent fever of 7 days duration, accompanied by abdominal pain is presented. She had regular gener
- PMID 24629905
- Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection-remission following high dose intravenous immunoglobulin.
- Lejeune A1, Cremer M, von Bernuth H, Edelmann A, Modrow S, Bührer C.
- European journal of pediatrics.Eur J Pediatr.2014 Dec;173(12):1723-6. doi: 10.1007/s00431-014-2420-5. Epub 2014 Oct 2.
- We report the course of dicygotic twins born preterm after 29 (4)/7 weeks of gestation due to congenital Parvovirus B19 infection causing fetal hydrops with severe anemia in one infant in whom intrauterine transfusion was impossible to perform and high levels of viremia in both infants. After bein
- PMID 25269997
Japanese Journal
- パルボウイルスB19による赤芽球癆の病態 (特集 ウイルス感染による造血器疾患の病態と治療)
- パルボウイルスB19感染による骨髄無形成クリーゼを来すも無事出産し得た, 自己免疫性溶血性貧血合併双胎妊婦の1例
- 石田 隆,宮崎 浩二,翁 祖誠 [他],鎌田 浩稔,木村 裕和,片山 卓爾,石井 隆司,大坂 学,檀原 幹生,東原 正明
- 日本内科学会雑誌 99(10), 2539-2541, 2010-10-10
- 37歳，女性．妊娠20週にHb7.6g/dlの貧血を認め，自己免疫性溶血性貧血と診断された．妊娠26週頃から発熱，関節痛，労作時息切れが出現したため緊急入院となった．網赤血球の低下，貧血の進行を認め，抗パルボウイルスB19 IgM抗体陽性より骨髄無形成クリーゼと診断し，酸素投与，洗浄赤血球輸血，さらに溶血性貧血に対してステロイド療法を施行した．網赤血球は徐々に回復し，母子とも無事に出産できた．
- NAID 10027508822
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- 関
- agenesis、aplasia、dysgenesis、hypoplasia、hypoplastic