antiseizure drug

出典: meddic

anticonvulsantanticonvulsant agentanticonvulsant druganticonvulsants
specific agents

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/17 17:15:22」(JST)

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英文文献

  • Small-Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection and Favorable Drug-Like Properties.
  • Smith GR, Brenneman DE, Zhang Y, Du Y, Reitz AB.Author information Fox Chase Chemical Diversity Center, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA, 18902, USA, gsmith@fc-cdci.com.AbstractSevere seizure activity is associated with reoccurring cycles of excitotoxicity and oxidative stress that result in progressive neuronal damage and death. Intervention with these pathological processes is a compelling disease-modifying strategy for the treatment of seizure disorders. We have optimized a series of small molecules for neuroprotective and anticonvulsant activity as well as altered their physical properties to address potential metabolic liabilities, to improve CNS penetration, and to prolong the duration of action in vivo. Utilizing phenotypic screening of hippocampal cultures with nutrient medium depleted of antioxidants as a disease model, cell death and decreased neuronal viability produced by acute treatment with glutamate or hydrogen peroxide were prevented. Modifications to our previously reported proof of concept compounds have resulted in a lead which has full neuroprotective action at <1 nM and antiseizure activity across six animal models including the kindled rat and displays excellent pharmacokinetics including high exposure to the brain. These modifications have also eliminated the requirement for a chiral molecule, removing the possibility of racemization and making large-scale synthesis more easily accessible. These studies strengthen our earlier findings which indicate that potent, multifunctional neuroprotective anticonvulsants are feasible within a single molecular entity which also possesses favorable CNS-active drug properties in vitro and in vivo.
  • Journal of molecular neuroscience : MN.J Mol Neurosci.2013 Nov 26. [Epub ahead of print]
  • Severe seizure activity is associated with reoccurring cycles of excitotoxicity and oxidative stress that result in progressive neuronal damage and death. Intervention with these pathological processes is a compelling disease-modifying strategy for the treatment of seizure disorders. We have optimiz
  • PMID 24277343
  • Molecular recognition study of Carbamazepine, antiseizure drug, by p-t-butyl calix(8)arene.
  • Meenakshi C, Jayabal P, Ramakrishnan V.Author information Department of Chemistry, Shri Meenakshi Government College for Women (Autonomous), Madurai 625 002, India.AbstractThe formation of inclusion complex of Carbamazepine, a antiseizure drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene was the host molecule and Carbamazepine was the guest molecule. Optical absorption spectral studies were carried out to study the molecular recognition properties of p-t-butyl calix(8)arene with Carbamazepine. The stochiometry of the host-guest complex and the binding constant were determined.
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2013 Nov 20;122C:447-450. doi: 10.1016/j.saa.2013.11.042. [Epub ahead of print]
  • The formation of inclusion complex of Carbamazepine, a antiseizure drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene was the host molecule and Carbamazepine was the guest molecule. Optical absorption spectral studies were carried out to study the mo
  • PMID 24322761
  • The Antiepileptic Potential of Nucleosides.
  • Kovacs Z, Kekesi KA, Juhasz G, Dobolyi A.Author information Arpad Dobolyi Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Karolyi Gaspar ter 4., 9700, Hungary. zskovacs@ttk.nyme.hu.AbstractDespite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal of evidence suggests that endogenous nucleosides, such as adenosine (Ado), guanosine (Guo), inosine (Ino) and uridine (Urd), participate in the regulation of pathomechanisms of epilepsy. Adenosine and its analogues, together with non-adenosine (non-Ado) nucleosides (e.g., Guo, Ino and Urd), have shown antiseizure activity. Adenosine kinase (ADK) inhibitors, Ado uptake inhibitors and Ado-releasing implants also have beneficial effects on epileptic seizures. These results suggest that nucleosides and their analogues, in addition to other modulators of the nucleoside system, could provide a new opportunity for the treatment of different types of epilepsies. Therefore, the aim of this review article is to summarize our present knowledge about the nucleoside system as a promising target in the treatment of epilepsy.
  • Current medicinal chemistry.Curr Med Chem.2013 Nov 19. [Epub ahead of print]
  • Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal of evidence suggests that endogenous nucleosi
  • PMID 24251559

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ESSNY 2009 MOST COMMON ANTISEIZURE DRUGS PLEASE SPEAK WITH YOUR DOCTOR ABOUT ANY QUESTIONS YOU MAY HAVE ABOUT MEDICATIONS This chart was developed solely for general information purposes ...

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★リンクテーブル★
先読み抗痙攣薬
リンク元anticonvulsant」「anticonvulsants」「anticonvulsant agent
関連記事drug」「antiseizure

抗痙攣薬」

  [★]

anticonvulsants, anticonvulsive drugs
抗てんかん薬



anticonvulsant」

  [★]

  • adj.
  • 抗痙攣の、抗けいれんの
  • n.
anticonvulsant agentanticonvulsant druganticonvulsantsanticonvulsiveantiseizureantiseizure drug

WordNet   license wordnet

「a drug used to treat or prevent convulsions (as in epilepsy)」
anticonvulsant drug, antiepileptic, antiepileptic drug

anticonvulsants」

  [★]

抗痙攣薬抗けいれん薬

anticonvulsantanticonvulsant agentanticonvulsant drugantiepileptic agentantiepileptic drugantiepilepticsantiseizure drug
Antiseizure drug(s)


anticonvulsant agent」

  [★]

anticonvulsantanticonvulsant druganticonvulsantsantiseizure drug

drug」

  [★]

drugs

WordNet   license wordnet

「use recreational drugs」
do drugs

WordNet   license wordnet

「administer a drug to; "They drugged the kidnapped tourist"」
dose

WordNet   license wordnet

「a substance that is used as a medicine or narcotic」

PrepTutorEJDIC   license prepejdic

「『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる」

antiseizure」

  [★]

  • 抗痙攣の、抗けいれんの、抗てんかん性の
anticonvulsantanticonvulsive




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