WordNet

arrange into a group or groups; "Can you group these shapes together?"
(chemistry) two or more atoms bound together as a single unit and forming part of a molecule (同)radical, chemical group
any number of entities (members) considered as a unit (同)grouping
a set that is closed, associative, has an identity element and every element has an inverse (同)mathematical group
form a group or group together (同)aggroup
the activity of putting things together in groups
a system for classifying things into groups (同)pigeonholing
a determining or causal element or factor; "education is an important determinant of ones outlook on life" (同)determiner, determinative, determining factor, causal factor
a square matrix used to solve simultaneous equations
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
of or relating to antigens

PrepTutorEJDIC

(…の)『群れ』,集まり,小集団《+of+名》 / (主義・系統・種類などを同じくする人・物の)『派』,『団体』 / (ポミュラーソング歌手の)グループ / (動・植物分類上の)群;(化学の)基,原子団;(地質学上の)界;(数学の)群;(言語学上の)語派 / …‘を'一群に集める,一団にする《+『名』+『together』》 / (系統的に)…‘を'分類する,調和よく配合する《+『名』+『together』》 / 集まる,群(集団)をなす
グループに分けること;分類法 / (集まった物の)配置,配合
決定要素 / 決定力のある
抗原(生物の体内にはいって免疫体を作る物質)

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1. インフルエンザの疫学 epidemiology of influenza
2. ペニシリンの皮膚試験 penicillin skin testing
3. 赤血球抗原および抗体 red blood cell antigens and antibodies
4. 即時型ペニシリンアレルギーの評価：皮膚反応試験に基づいた診断方法とその他のβ-ラクタム系抗菌薬との交差反応性試験 allergy evaluation for immediate penicillin allergy skin test based diagnostic strategies and cross reactivity with other beta lactam antibiotics
5. アルコール性肝疾患の病因 pathogenesis of alcoholic liver disease

English Journal

Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

Muller I, Giani C, Zhang L, Grennan-Jones FA, Fiore E, Belardi V, Rosellini V, Funel N, Campani D, Giustarini E, Lewis MD, Bakhsh AD, Roncella M, Ghilli M, Vitti P, Dayan CM, Ludgate ME.Author information Thyroid Research Group Institute of Molecular & Experimental Medicine School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom; Department of Endocrinology, University of Pisa, Pisa, Italy.AbstractWomen with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in women without TPOAb. We hypothesize a BC/thyroid shared antigen that provides a target for humoral or cell-mediated immune activity; candidates include the sodium/iodide symporter (expressed in thyroid and BC), cross-reacting epitopes in TPO and lactoperoxidase (LPO) or TPO itself. As the association is with TPOAb, we investigated TPO expression in BC, breast peritumoral tissue (PT), other tissues (tumoral and not) and thyroid as positive control. Transcripts for known and novel TPO isoforms were detected in BC (n = 8) and PT (n = 8) but at approximately 10(4) -fold lower than in thyroid while in non-BC tumors (n = 5) they were at the limit of detection. TPO was expressed also in adipose tissue (n = 17), 10(3) -fold lower than in thyroid. Full length TPO (Mr 105-110 kDa) was detected in Western blots in the majority of examined tissues; preabsorption of the TPO antibody with recombinant TPO (but not LPO) reduced the signal, indicating specificity. The same occurred with some lower molecular weight bands, which could correspond to smaller TPO transcript isoforms, present in all samples. In conclusion, TPO is weakly expressed in BC and other tissues; this could partly explain the high frequency and protective role of TPOAb in BC patients. Further studies will investigate tissue specificity, function and immunogenicity of the novel TPO variants (some BC-specific) identified.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1706-14. doi: 10.1002/ijc.28493. Epub 2013 Oct 15.
Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in women without TPOAb. We hypothesize a BC/thyroid s
PMID 24114667

Small molecule mimetics of an interferon-α receptor interacting domain.

Bello AM1, Wei L1, Majchrzak-Kita B2, Salum N3, Purohit MK4, Fish EN5, Kotra LP6.Author information 1Center for Molecular Design and Preformulations, University Health Network, Toronto, Ontario M5G 1L7, Canada; Toronto General Research Institute, Toronto, Ontario M5G 2M1, Canada; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.2Toronto General Research Institute, Toronto, Ontario M5G 2M1, Canada.3Center for Molecular Design and Preformulations, University Health Network, Toronto, Ontario M5G 1L7, Canada; Federal University of Paraná, Curitiba, Paraná, Brazil.4Center for Molecular Design and Preformulations, University Health Network, Toronto, Ontario M5G 1L7, Canada; Department of Pharmacy, Birla Institute of Technology & Science, Pilani 333 031, India.5Toronto General Research Institute, Toronto, Ontario M5G 2M1, Canada; Department of Immunology, University of Toronto, Toronto, Canada.6Center for Molecular Design and Preformulations, University Health Network, Toronto, Ontario M5G 1L7, Canada; Toronto General Research Institute, Toronto, Ontario M5G 2M1, Canada; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: lkotra@uhnres.utoronto.ca.AbstractSmall molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features represented by the key residues Leu30, Arg33, and Asp35 in IRRP-1. Three of these compounds exhibited potential mimicry to IRRP-1 and, in cell based assays, as predicted, effectively inhibited IFNAR activation by IFN-α. Of these, compound 3 did not display cell toxicity and reduced IFN-α-inducible STAT1 phosphorylation and STAT-DNA binding. Based on physicochemical properties' analyses, our data suggest that moieties with acidic pKa on the small molecule may be a necessary element for mimicking the carboxyl group of Asp35 in IRRP-1. Our data confirm the relevance of this strategy of molecular mimicry of ligand-receptor interaction domains of protein partners for small molecule drug discovery.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Feb 1;22(3):978-85. doi: 10.1016/j.bmc.2013.12.049. Epub 2014 Jan 2.
Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features r
PMID 24433965

Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury.

Ryu JK, Kim DH, Song KM, Yi T, Suh JK, Song SU.Author information National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon, Korea.AbstractINTRODUCTION: Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of stem cell therapy is the heterogeneous nature of the isolated cells, which may cause different treatment outcomes.
The journal of sexual medicine.J Sex Med.2014 Feb;11(2):411-23. doi: 10.1111/jsm.12380. Epub 2013 Nov 20.
INTRODUCTION: Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of stem cell therapy is the hete
PMID 24251583

Japanese Journal

Streptococcus rattus に対する単クロン抗体 : 細胞壁抗原決定基の免疫化学的性質とその局在

五嶋淑雄
九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 50(2), 415-431, 1996-04-25
… rattus strains and not with any other strain of the mutans group nor with other streptococcal strains tested. … It was shown that the antigen determinant was irregularly localized on thread-like projections on the surface of the cell wall. …
NAID 10016249092

Streptococcus mutans の菌体外多糖抗原上に存在する菌種特異的抗原決定基に対する単クローン抗体

秋山保之
九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 49(5), 360-372, 1995-10-25
… mutans-species specific antigenic determinant on the extracellular polysaccharide antigen were prepared and characterized as probes for the investigation of the infection and caries-generating mechanism by the bacterium. … mutans among mutans group streptococci were obtained. … Competitive enzyme immunoassay using various haptenic sugars as inhibitors revealed that these four monoclonal antibodies recognized the determinant containing N-acetyl-D-glucosamine residue. …
NAID 110003005315

ミュータンス群レンサ球菌 (Streptococcus rattus) に関する研究 : 抗血清による特異抗原の化学的, 免疫化学的性状とその細胞局在性

植垣健二
九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 46(4), 558-573, 1992-08-25
… A specific antiserum was prepared by immunizing a rabbit with whole cells of Streptococcus rattus strain FA1 and absorption with heterologous strains of the mutans group of streptococci. … The absorbed antiserum was tested for its specificity in double diffusion, immunoelectrophoresis enzyme and radiommunoassay with whole cells of the mutans group of streptococci and other oral streptococcal species. …
NAID 110003004843