antifungal drug

出典: meddic

抗真菌薬

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/12 06:01:52」(JST)

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英文文献

  • Impacts of chemical enhancers on skin permeation and deposition of terbinafine.
  • Erdal MS, Peköz AY, Aksu B, Araman A.Author information Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Beyazıt , Istanbul , Turkey and.AbstractAbstract Context/Objective: The addition of chemical enhancers into formulations is the most commonly employed approach to overcome the skin barrier. The objective of this work was to evaluate the effect of vehicle and chemical enhancers on the skin permeation and accumulation of terbinafine, an allylamine antifungal drug. Methods: Terbinafine (1% w/w) was formulated as a Carbopol 934 P gel formulation in presence and absence of three chemical enhancers, nerolidol, dl-limonene and urea. Terbinafine distribution and deposition in stratum corneum (SC) and skin following 8-h ex vivo permeation study was determined using a sequential tape stripping procedure. The conformational order of SC lipids was investigated by ATR-FTIR spectroscopy. Results and discussion: Nerolidol containing gel formulation produced significantly higher enhancement in terbinafine permeation through skin and its skin accumulation was increased. ATR-FTIR results showed enhancer induced lipid bilayer disruption in SC. Urea resulted in enhanced permeation of terbinafine across the skin and a balanced distribution to the SC was achieved. But, dl-limonene could not minimize the accumulation of terbinafine in the upper SC. Conclusion: Nerolidol dramatically improved the skin permeation and deposition of terbinafine in the skin that might help to optimize targeting of the drug to the epidermal sites as required for both of superficial and deep cutaneous fungal infections.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 Aug;19(5):565-70. doi: 10.3109/10837450.2013.813538. Epub 2013 Jul 10.
  • Abstract Context/Objective: The addition of chemical enhancers into formulations is the most commonly employed approach to overcome the skin barrier. The objective of this work was to evaluate the effect of vehicle and chemical enhancers on the skin permeation and accumulation of terbinafine, an all
  • PMID 23841559
  • Polymeric microparticles-based formulation for the eradication of cutaneous candidiasis: development and characterization.
  • Kumar L, Verma S, Jamwal S, Vaidya S, Vaidya B.Author information Department of Pharmaceutics .AbstractAbstract Cutaneous candidiasis is a common topical fungal infection which may be more prominent in patients associated with AIDS. It is usually treated by conventional formulations such as cream, gel, which show various adverse effects on skin along with systemic absorption. To overcome these drawbacks, various novel drug delivery systems have been explored. Poly(lactic-co-glycolic acid) (PLGA)-based microparticulate systems have shown good dermal penetration after topical application. Therefore, in the present study clotrimazole-loaded PLGA microspheres were prepared for targeted dermal delivery. Microspheres were prepared by using a single emulsification (oil-in-water, O/W) evaporation technique and characterized for different parameters. Prepared microparticulate systems were dispersed in Carbopol 934® gel and antifungal activity was carried out on experimentally induced cutaneous candidiasis in immunosuppressed guinea pigs. Particle size of optimized formulation was 2.9 µm along with 74.85% entrapment of drug. Skin retention studies revealed that drug accumulation in the skin was higher with microspheres gel as compared to marketed gel. Confocal microscopy of skin further confirmed penetration of microspheres up to 50 µm into the dermal region. In-vivo antifungal activity studies demonstrated that microsphere gel showed better therapeutic activity, lowest number of cfu/ml was recorded, as compared to marketed gel after 96 h of application. Based on the results of the study, it can be concluded that PLGA microparticles may be promising carriers to deliver clotrimazole intradermally for the treatment of invasive fungal infections.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 May;19(3):318-25. doi: 10.3109/10837450.2013.778874. Epub 2013 Apr 8.
  • Abstract Cutaneous candidiasis is a common topical fungal infection which may be more prominent in patients associated with AIDS. It is usually treated by conventional formulations such as cream, gel, which show various adverse effects on skin along with systemic absorption. To overcome these drawba
  • PMID 23560821
  • Centauries as underestimated food additives: antioxidant and antimicrobial potential.
  • Siler B, Zivković S, Banjanac T, Cvetković J, Nestorović Živković J, Cirić A, Soković M, Mišić D.Author information Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.AbstractMethanol extracts of aerial parts and roots of five centaury species (Centaurium erythraea, C. tenuiflorum, C. littorale ssp. uliginosum, C. pulchellum, and Schenkia spicata) were analysed for their main secondary metabolites: secoiridoid glycosides, a group of monoterpenoid compounds, and phenolics (xanthones and flavonoids), and further investigated for antioxidant capacity and antimicrobial activity. The results of ABTS, DPPH, and FRAP assays showed that above ground parts generally displayed up to 13 times higher antioxidant activity compared to roots, which should be related to higher phenolics content, especially flavonoids, in green plant organs. Secoiridoid glycosides showed no antioxidant activity. All the tested extracts demonstrated appreciative antibacterial (0.05-0.5 mg ml(-1)) and strong antifungal activity (0.1-0.6 mg ml(-1)). Our results imply that above ground parts of all centaury species studied, could be recommended for human usage as a rich source of natural antioxidants and also in food industry as strong antimicrobial agents for food preservation.
  • Food chemistry.Food Chem.2014 Mar 15;147:367-76. doi: 10.1016/j.foodchem.2013.10.007. Epub 2013 Oct 11.
  • Methanol extracts of aerial parts and roots of five centaury species (Centaurium erythraea, C. tenuiflorum, C. littorale ssp. uliginosum, C. pulchellum, and Schenkia spicata) were analysed for their main secondary metabolites: secoiridoid glycosides, a group of monoterpenoid compounds, and phenolics
  • PMID 24206732

和文文献

  • アレルギー性気管支肺アスペルギルス症 (特集 高IgE血症を伴う難治疾患 : 基礎と臨床)
  • 山崎 章
  • 臨床免疫・アレルギー科 63(3), 232-238, 2015-03
  • NAID 40020393264
  • ドラッグデリバリーシステム(4)放出制御製剤
  • 岡田 弘晃
  • 日本防菌防黴学会誌 = Journal of Antibacterial and Antifungal
  • NAID 40020386440
  • ドラッグデリバリーシステム(3)抗がん剤内包ミセルの基礎から臨床
  • 松村 保広
  • 日本防菌防黴学会誌 = Journal of Antibacterial and Antifungal
  • NAID 40020353311

関連リンク

^ a b doctorfungus > Antifungal Drug Interactions Content Director: Russell E. Lewis, Pharm.D. Retrieved on Jan 23, 2010 ^ [Baginski M, Czub B. Amphotericin B and its new derivatives. Current Drug Metabolism. 2009 Jun;10(5) : 459 ...
antifungal [an″te-, an″ti-fung´gal] destructive to or checking the growth of fungi; called alsoantimycotic. antifungal agent. an·ti·my·cot·ic (an'tē-mī-kot'ik), Antagonistic to fungi. Synonym(s): antifungal [anti- + G. mykēs, fungus] antifungal ...

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★リンクテーブル★
リンク元抗真菌薬」「antimycotic」「antimycotics」「antimycotic agent」「抗真菌剤
関連記事drug」「antifungal」「antifungals

抗真菌薬」

  [★]

antifungal drug, antifungal, antimycotic
真菌真菌症抗真菌薬一覧


作用機序

作用部位 薬物 作用機序 スペクトル
細胞膜 キャンディン系抗真菌薬 1,3-β-D-グルカン合成阻害 カンジダとアスペルギウス。ムコールクリプトコッカスには無効
細胞膜 アムホテリシンB エルゴステロールに結合し細胞膜破壊、殺菌的 広スペクトル
アゾール系抗真菌薬 エルゴステロール合成阻害 カンジダとアスペルギウス
フルシトシン 核酸合成阻害 カンジダのみ

抗真菌薬一覧

antimycotic」

  [★]

  • adj.
  • 抗真菌の
  • n.
antifungalantifungal agentantifungal drugantifungalsantimycotic agentantimycotics


antimycotics」

  [★]

抗真菌薬抗真菌剤

antifungalantifungal agentantifungal drugantifungalsantimycoticantimycotic agent


antimycotic agent」

  [★]

antifungalantifungal agentantifungal drugantifungalsantimycoticantimycotics


抗真菌剤」

  [★]

antifungal agentantifungal drugantimycotic agentantimycotic
抗かび剤抗真菌抗真菌薬


drug」

  [★]

drugs

WordNet   license wordnet

「use recreational drugs」
do drugs

WordNet   license wordnet

「administer a drug to; "They drugged the kidnapped tourist"」
dose

WordNet   license wordnet

「a substance that is used as a medicine or narcotic」

PrepTutorEJDIC   license prepejdic

「『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる」


antifungal」

  [★]

  • adj.
  • 抗真菌性の、抗真菌の
  • n.
antifungal agentantifungal drugantifungalsantimycoticantimycotic agentantimycotics

WordNet   license wordnet

「any agent that destroys or prevents the growth of fungi」
antifungal agent, fungicide, antimycotic, antimycotic agent


antifungals」

  [★]

抗真菌薬

antifungalantifungal agentantifungal drugantimycoticantimycotic agentantimycotics




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