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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/12 01:16:44」(JST)

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An antiestrogen is a substance that blocks the production or utilization of estrogens,^[1] or inhibits their effects.^[2] Estrogens are the family of hormones that promote the development and maintenance of female sex characteristics.

Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.

Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class.^[3] Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.^[4]

Hot flashes, osteoporosis, breast atrophy, and vaginal dryness can be side effects of antiestrogens.

References

^ "Definition of antiestrogen - NCI Dictionary of Cancer Terms, Definition of antiestrogen - NCI Dictionary of Cancer Terms". ,
^ "antiestrogen" at Dorland's Medical Dictionary
^ Riggins RB, Bouton AH, Liu MC, Clarke R (2005). "Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer". Vitam. Horm. 71: 201–37. doi:10.1016/S0083-6729(05)71007-4. PMID 16112269.
^ Thiantanawat, Long, Brodie, Apinya, Brian, Angela (2003-11-15). "Signaling Pathways of Apoptosis Activated by Aromatase Inhibitors and Antiestrogens". The Journal of Cancer Research. Retrieved 2015-04-13.

External links

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

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UpToDate Contents

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1. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention
2. 非転移性ホルモン受容体陽性乳癌に対する補助内分泌療法 adjuvant endocrine therapy for non metastatic hormone receptor positive breast cancer
3. 転移性ホルモン受容体陽性乳癌に対する治療アプローチ：内分泌療法 treatment approach to metastatic hormone receptor positive breast cancer endocrine therapy
4. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
5. BRCA1 and BRCA2-associated hereditary breast and ovarian cancer

English Journal

Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry.

Görgens C1, Guddat S2, Thomas A2, Wachsmuth P2, Orlovius AK2, Sigmund G2, Thevis M2, Schänzer W2.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Nov 30;131:482-496. doi: 10.1016/j.jpba.2016.09.015. Epub 2016 Sep 15.
So far, in sports drug testing compounds of different classes are processed and measured using different screening procedures. The constantly increasing number of samples in doping analysis, as well as the large number of substances with doping related, pharmacological effects require the developmen
PMID 27693991

A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.

Zhao LM1, Jin HS1, Liu J2, Skaar TC2, Ipe J2, Lv W3, Flockhart DA2, Cushman M4.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Nov 1;24(21):5400-5409. doi: 10.1016/j.bmc.2016.08.064. Epub 2016 Aug 31.
The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) derivatives with dual aromatase inhibitory activity
PMID 27647367

Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Teixeira D1, Marques C2,3, Pestana D2,3, Faria A2,4,5, Norberto S2, Calhau C2,3, Monteiro R2,6.
Environmental toxicology.Environ Toxicol.2016 Nov;31(11):1496-1509. doi: 10.1002/tox.22154. Epub 2015 May 26.
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a ce
PMID 26011183

Japanese Journal

内膜細胞診陰性の内膜ポリープ内に内膜異型増殖症を認めたタモキシフェン内服中の 1 例

日本臨床細胞学会雑誌 53(4), 318-322, 2014
NAID 130004691309

エストロゲン受容体陽性乳癌細胞における抗エストロゲン薬とmTOR阻害薬エベロリムスの細胞増殖及び癌幹細胞制御に対する効果

川崎医学会誌 39(3), 65-79, 2013
NAID 110009632690

2) 薄い子宮内膜(不妊治療の問題点(難治性不妊症)とその対策,生殖・内分泌クリニカルカンファレンス,第64回日本産科婦人科学会学術講演会生涯研修プログラム関係講演要旨)

日本産科婦人科學會雜誌 64(9), "N-202"-"N-206", 2012-09-01
NAID 110009509142

Related Pictures

★リンクテーブル★

リンク元	「抗エストロゲン剤」「estrogen receptor modulator」「抗女性ホルモン剤」
拡張検索	「antiestrogen therapy」「antiestrogenic」
関連記事	「antiestrogens」