Bcl-2, IAP inhibitor of apoptosis protein, manganese superoxide dismutase(Mn-SOD)

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1. 筋萎縮性側索硬化症の疫学および病因epidemiology and pathogenesis of amyotrophic lateral sclerosis [show details]
…apoptosis including DNA fragmentation, caspase activation, and altered expression of the antiapoptotic protein Bcl-2 . Some evidence suggests that apoptosis may be a late pathway for motor neuron degeneration …
2. 進行性前立腺癌の治療に対する実験的アプローチinvestigational approaches for the treatment of advanced prostate cancer [show details]
…trial failed to demonstrate a statistically significant improvement in overall survival. Antiapoptotic proteins such as clusterin and survivin are expressed at high levels in prostate cancer cells that …
3. 血管新生阻害剤の概要overview of angiogenesis inhibitors [show details]
…invasion via stimulation of VEGF, inhibition of immune surveillance, and upregulation of the antiapoptotic protein bcl-2 and various matrix metalloproteinases. An alternative or complementary method for attacking …
4. 慢性リンパ性白血病の病態生理および遺伝学的特徴pathophysiology and genetic features of chronic lymphocytic leukemia [show details]
…interact directly with and result in the upregulation of the B cell leukemia/lymphoma 2 (BCL2) antiapoptotic protein in many cases of CLL/SLL . These two mRNAs are not present in CLL/SLL with 13q deletion, a …
5. プロテインＳ欠乏症protein s deficiency [show details]
… cofactor for activated protein C, which inactivates procoagulant factors Va and VIIIa, reducing thrombin generation . Protein S also serves as a cofactor for activated protein C in enhancing fibrinolysis …

English Journal

Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway.

Shen X, Sun H, Cui H, Jin Y, Jin W, Cui X, Guo J.
Journal of cellular biochemistry. 2019 Aug;120(8)12273-12279.
The aim of this study was to research the antiapoptotic effect of astragaloside, the principal component of Astragalus membranaceus (Fisch) Bge, in human gingiva cells induced by lipopolysaccharide (LPS). According to the treatment, human gingiva cells were divided into five groups, including (1) co
PMID 31001851

Quercetin sensitizes human myeloid leukemia KG-1 cells against TRAIL-induced apoptosis.

Naimi A, Entezari A, Hagh MF, Hassanzadeh A, Saraei R, Solali S.
Journal of cellular physiology. 2019 Aug;234(8)13233-13241.
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Conventional treatments are associated with cytotoxicity and systemic side effects. Hence, efforts in the field of cancer treatment are focused on finding the strategies which can specifically target the tumor cells without af
PMID 30589076

Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.

Lee CW, Chi MC, Chang TM, Liu JF.
Journal of cellular physiology. 2019 Aug;234(8)13157-13168.
Osteosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. However, because of side effects and drug resistance in chemotherapy and the insufficiency of an effective adjuvant therapy for osteosarcoma, it is necessary to research novel treatments.
PMID 30549031

Japanese Journal

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Kasai Shuya,Yamazaki Hiromi,Tanji Kunikazu,Engler Máté János,Matsumiya Tomoh,Itoh Ken
Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 64(1), 1-12, 2019
… There are several branches of the mitochondrial retrograde signaling, including mitochondrial unfolded protein response (UPR<sup>MT</sup>), but recent observations increasingly show the importance of the ISR-ATF4 pathway in mitochondrial retrograde signaling. … Furthermore, Nrf2, a master regulator of the oxidative stress response, interacts with ATF4 and cooperatively upregulates a battery of antioxidant and antiapoptotic genes while repressing the ATF4-mediated proapoptotic gene, CHOP. …
NAID 130007542293

A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist

Morita Akinori,Takahashi Ippei,Sasatani Megumi,Aoki Shin,Wang Bing,Ariyasu Shinya,Tanaka Kaoru,Yamaguchi Tetsuji,Sawa Akiko,Nishi Yurie,Teraoka Tatsuro,Ujita Shohei,Kawate Yosuke,Yanagawa Chihiro,Tanimoto Keiji,Enomoto Atsushi,Nenoi Mitsuru,Kamiya Kenji,Nagata Yasushi,Hosoi Yoshio,Inaba Toshiya
Molecular Cancer Therapeutics 17(2), 432-442, 2018-02
… The specificity of 5CHQ for p53 and p21 was demonstrated by silencing the expression of each protein. … In addition, 5-chloro-8-methoxyquinoline itself had no antiapoptotic activity, indicating that the hydroxyl group at the 8-position is required for its antiapoptotic activity. …
NAID 120006552353

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Kasai Shuya,Yamazaki Hiromi,Tanji Kunikazu,Engler Máté János,Matsumiya Tomoh,Itoh Ken
Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ, 2018
… There are several branches of the mitochondrial retrograde signaling, including mitochondrial unfolded protein response (UPR<sup>MT</sup>), but recent observations increasingly show the importance of the ISR-ATF4 pathway in mitochondrial retrograde signaling. … Furthermore, Nrf2, a master regulator of the oxidative stress response, interacts with ATF4 and cooperatively upregulates a battery of antioxidant and antiapoptotic genes while repressing the ATF4-mediated proapoptotic gene, CHOP. …
NAID 130007484284