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1. 薬物アレルギー患者へのアプローチ an approach to the patient with drug allergy
2. 抗マラリア剤：概要 antimalarial drugs an overview
3. 成人における薬物中毒への一般的アプローチ general approach to drug poisoning in adults
4. リウマチ性疾患における免疫抑制剤および疾患修飾剤の使用の概要 overview of the use of immunosuppressive and disease modifying drugs in the rheumatic diseases
5. 処方剤の誤用：疫学、予防、同定、およびマネージメント prescription drug misuse epidemiology prevention identification and management

Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel NaV1.5: A Novel Mechanism of Drug Action.

Beyder A, Strege PR, Reyes S, Bernard CE, Terzic A, Makielski J, Ackerman MJ, Farrugia G.SourceDivision of Gastroenterology & Hepatology, Enteric Neuroscience Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905. farrugia.gianrico@mayo.edu.
Circulation.Circulation.2012 Jun 5;125(22):2698-706. Epub 2012 May 7.
BACKGROUND: Na(V)1.5 is a mechanosensitive voltage-gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties.METHODS AND RESULTS: Mechano
PMID 22565935

A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention.

Pelliccia F, Pasceri V, Marazzi G, Rosano G, Greco C, Gaudio C.SourceDepartment of Heart and Great Vessels Attilio Reale, La Sapienza University, Rome, Italy.
American heart journal.Am Heart J.2012 Jun;163(6):1019-23. Epub 2012 May 21.
BACKGROUND: Ranolazine is a new antianginal drug that reduces intracellular sodium and calcium accumulation during ischemia, thus potentially limiting myocardial ischemia. It remains unknown, however, if the drug can play a role in the pathophysiology of periprocedural myocardial infarction. The aim
PMID 22709755