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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/24 23:53:21」(JST)

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  • The blockade of angiotensin AT1 and aldosterone receptors protects rats from synthetic androgen-induced cardiac autonomic dysfunction.
  • Marques Neto SR, Silva Ada H, Santos MC, Ferraz EF, Nascimento JH.SourceInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Exercise and Sports Sciences Graduate Program, Gama Filho University, Rio de Janeiro, Brazil.
  • Acta physiologica (Oxford, England).Acta Physiol (Oxf).2013 Jun;208(2):166-71. doi: 10.1111/apha.12056. Epub 2013 Jan 18.
  • AIM: This study aimed to evaluate the combined effects of exercise and antagonists of the angiotensin II and aldosterone receptors on cardiac autonomic regulation and ventricular repolarization in rats chronically treated with nandrolone decanoate (ND), a synthetic androgen.METHODS: Thirty male Wist
  • PMID 23279762
  • The systematic structure-activity relationship to predict how flavones bind to human androgen receptor for their antagonistic activity.
  • Tamura H, Yoshioka M, Hasegawa M, Hosoda A, Matsugi M, Akamatsu M.SourceDepartment of Environmental Bioscience, Meijo University, Nagoya 468-8502, Japan. Electronic address:
  • Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Jun 1;21(11):2968-74. doi: 10.1016/j.bmc.2013.03.060. Epub 2013 Apr 2.
  • Although flavones act as potent androgen receptor (AR) antagonists, it remains unclear how flavones interact with AR. The aim of this in silico study was to investigate the molecular recognition processes of newly synthesized 5,4'-difluoroflavone with the highest activity (IC50 value=0.19μM) in the
  • PMID 23611768
  • Luteinizing hormone-releasing hormone (LHRH) receptor agonists vs antagonists: a matter of the receptors?
  • Tolkach Y, Joniau S, Van Poppel H.SourceUrology Clinic, Military Medical Academy, Saint-Petersburg, Russia.
  • BJU international.BJU Int.2013 Jun;111(7):1021-30. doi: 10.1111/j.1464-410X.2013.11796.x. Epub 2013 Feb 18.
  • Luteinizing hormone-releasing hormone (LHRH) agonists and antagonists are commonly used androgen deprivation therapies prescribed for patients with advanced prostate cancer (PCa). Both types of agent target the receptor for LHRH but differ in their mode of action: agonists, via pituitary LRHR recept
  • PMID 23418666


  • 特別講演(第142回東邦医学会例会) 前立腺癌に対するホルモン療法のパラダイム・シフト
  • 鈴木 啓悦
  • 東邦医学会雑誌 = Journal of Medical Society of Toho University 60(4), 204-212, 2013-07
  • … However, in addition to surgical castration, development of novel hormonal agents such as luteinising-hormone-releasing hormone(LH-RH)analogues and antiandrogens has yielded new hormonal treatment modalities[intermittent hormonal therapy and combined androgen blockade(CAB)], and it is in this medical context that a new medical term―castration-resistant prostate cancer(CRPC)―has been widely used since 2008. …
  • NAID 120005318030
  • 前立腺がんにおけるホルモン療法
  • 井上 高光,大山 力,羽渕 友則
  • Drug delivery system 24(4), 415-420, 2009-07-30
  • 初診時前立腺がんの約80~90%はアンドロゲン依存性の性質を示す.転移を有する前立腺がん患者に対しては,根治を目指す前立腺全摘術や放射線療法よりもホルモン療法が通常選択される.前立腺がんにおけるホルモン療法の目的は,アンドロゲン受容体へのシグナルを減少させ腫瘍を縮小させるところにある.現在本邦では,外科的去勢術(両側精巣摘除),LH-RHアゴニスト,抗アンドロゲン剤,グルココルチコイドを組み合わせ …
  • NAID 10025535436
  • 内分泌療法再燃前立腺癌に対する酢酸クロルマジノンの有用性の検討
  • 江原 英俊,加藤 成一,中根 慶太,加藤 卓,高田 俊彦,小島 圭太郎,亀井 信吾,萩原 徳康,柚原 一哉,高橋 義人,藤本 佳則,藤広 茂,蟹本 雄右,出口 隆
  • 泌尿器科紀要 55(4), 199-203, 2009-04
  • … Sixteen patients with relapsed prostate cancer after treatment with CAB, including surgical or medical castration and nonsteroidal antiandrogens, 80 mg bicalutamide daily or 375 mg flutamide daily, were enrolled. …
  • NAID 120001265571


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アンドロゲン拮抗薬 androgen antagonist、男性ホルモン拮抗薬 male sex hormone antagonist
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  • 前立腺肥大症や前立腺癌の内分泌療法に用いられる。
  • 合成エストロゲン
  • アンドロゲン受容体に対する競合阻害
  • (ヒドロキシプロゲステロン誘導体)シプロテロン
  • (合成黄体ホルモン製剤)クロルマジノン
  • (テストステロン系)オキセンドロン:前立腺でアンドロゲンと競合阻害し、アンドロゲンのアンドロゲン受容体への結合を阻害。