anti-glomerular basement-membrane antibody disease

抗糸球体基底膜抗体病

WordNet

1. an impairment of health or a condition of abnormal functioning
2. the lowermost portion of a structure partly or wholly below ground level; often used for storage (同)cellar
3. the ground floor facade or interior in Renaissance architecture
4. not in favor of (an action or proposal etc.)
5. a person who is opposed (to an action or policy or practice etc.); "the antis smelled victory after a long battle"
6. social insect living in organized colonies; characteristically the males and fertile queen have wings during breeding season; wingless sterile females are the workers (同)emmet, pismire
7. a thin pliable sheet of material
8. a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer

PrepTutorEJDIC

1. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
2. 女性の話術芸人 =diseur
3. 地階,地下室
4. 《話》(特定の慣習・政策・行動などに)反対する人
5. 『アリ』
6. =ain't
7. (生物の)膜,皮膜

UpToDate Contents

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• 1. 抗GBM抗体（グッドパスチャー）病の病因および診断 pathogenesis and diagnosis of anti gbm antibody goodpastures disease
• 2. 抗GBM抗体（グッドパスチャー）病の治療 treatment of anti gbm antibody goodpastures disease
• 3. 抗GBM抗体病：移植後の再発 anti gbm antibody disease recurrence after transplantation
• 4. 急速進行性（半月形）糸球体腎炎の分類および治療の概要 overview of the classification and treatment of rapidly progressive crescentic glomerulonephritis
• 5. 遺伝性腎炎（アルポート症候群）の臨床症状、診断および治療 clinical manifestations diagnosis and treatment of hereditary nephritis alport syndrome

English Journal

• Outcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study.

• Kimmoun A1,2, Baux E1,2, Das V3, Terzi N4, Talec P5, Asfar P5, Ehrmann S6, Geri G7, Grange S8, Anguel N9, Demoule A10, Moreau AS11, Azoulay E12, Quenot JP13, Boisramé-Helms J14, Louis G15, Sonneville R16, Girerd N17, Ducrocq N1,2, Agrinier N18, Wahl D19, Puéchal X20, Levy B21,22.
• Critical care (London, England).Crit Care.2016 Jan 26;20(1):27. doi: 10.1186/s13054-016-1189-5.
• BACKGROUND: The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation of small-vessel vasculitis are poorly reported. The aim of the present study was to determine the mortality rate and prognostic factors of patients admitted to the ICU for acute small-vessel vascul
• PMID 26812945

• Case report: anti-glomerular basement membrane antibody disease with normal renal function.

• Nagano C1, Goto Y2, Kasahara K3, Kuroyanagi Y4.
• BMC nephrology.BMC Nephrol.2015 Nov 4;16:185. doi: 10.1186/s12882-015-0179-1.
• BACKGROUND: Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis caused by autoantibodies against the α3-chain of type IV collagen in the GBM.CASE PRESENTATION: An 8-year-old girl with hematuria and proteinuri
• PMID 26537989

• The Case | A 48-year-old man with pulmonary-renal syndrome.

• Schreiber A1, Schindler R2, Adcock Funk DM3, Kahl A2.
• Kidney international.Kidney Int.2015 Mar;87(3):667-8. doi: 10.1038/ki.2014.21.
• PMID 25723644

Japanese Journal

• 抗糸球体基底膜(GBM)抗体疾患に対するアフェレシス療法(<特集>血管炎症候群とアフェレシス)

• 日本アフェレシス学会雑誌 34(2), 126-130, 2015-05-31
• NAID 110009964087

• Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Negative Small Vessel Vasculitis: A Rare Cause of Pulmonary Renal Syndrome

• Internal Medicine 54(21), 2759-2763, 2015
• NAID 130005106600

• Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: <i>In Vivo</i> and <i>in Silico</i> Studies

• Biological and Pharmaceutical Bulletin 38(8), 1175-1184, 2015
• NAID 130005090652

Related Links

• Anti-Glomerular Basement Membrane Disease

Anti-glomerular basement membrane disease (anti-GBM) is a rare but well-characterized cause of glomerulonephritis. It is defined by the presence of autoantibodies directed at specific antigenic targets within the ...

• Anti-glomerular basement membrane antibody disease: A rare ...

1. Introduction Anti-glomerular basement membrane antibody disease is a rare cause of glomerulonephritis. It is defined by the presence of serum anti-GBM antibody and/or linear binding of IgG detected by direct immunofluorescence ...

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★リンクテーブル★

リンク元	「抗糸球体基底膜抗体病」
関連記事	「disease」「glomerular」「basement」「ant」「anti」

「抗糸球体基底膜抗体病」

　　[★]

英

anti-glomerular basement-membrane antibody disease, anti-glomerular basement membrane disease

同

抗GBM病。グッドパスチャー症候群 Goodpasture syndrome, Goodpasture's syndrome Goodpasture症候群

関

抗糸球体基底膜疾患、実験的糸球体腎炎。anti-GBM

血管炎-小型血管炎-免疫複合体性小型血管炎

• 肺と腎が冒される
• 抗基底膜抗体によるII型アレルギー反応が起こる

概念

• 肺出血と半月体形成を伴う腎炎

• 急速進行性腎炎症候群(RPGN)を呈する

定義

CHCC 2012

• 糸球体毛細血管、肺毛細血管のいずれか一方、または双方を障害し、抗GBM抗体の沈着を伴う血管炎。肺病変は肺出血を腎病変は壊死性・半月体を伴う糸球体腎炎を引き起こす。

病因

• 抗基底膜抗体(抗糸球体基底膜抗体)が糸球体基底膜と肺胞基底膜とに反応

病理

• 基底膜に線状の抗体IgGとC3の沈着を認める(linear deposition of IgG)

• 図：BPT. Fig.14-4 B. linear, characteristic of classic anti-GBM antibody GN

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「glomerular」

　　[★]

• adj.

• 糸球体の、腎糸球体の

関

glomeruli、glomerulus、kidney glomerulus、renal glomeruli、renal glomerulus

　

「basement」

　　[★]

• n.

• 基底、地階

関

basal、bases、basis、fundus、ground

　 　 　

「ant」

　　[★]

• n.

• アリ

同

ants, stinging

　 　 　

「anti」

　　[★]

• comb form.

• 抗、アンチ