制酸薬
WordNet
- acting to neutralize acid (especially in the stomach)
- an agent that counteracts or neutralizes acidity (especially in the stomach) (同)gastric antacid, alkalizer, alkaliser, antiacid
PrepTutorEJDIC
- (特に胃の中で)酸を中和する / (特に胃の)酸中和剤,制酸剤
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/16 02:14:34」(JST)
[Wiki en表示]
An antacid is a substance which neutralizes stomach acidity, which in turn relieves heartburn, indigestion or stomach upset.[1]
Contents
- 1 Medical uses
- 2 Side effects
- 3 Mechanism of action
- 4 Formulations
- 5 References
Medical uses
Wyeth amphojel tablets of aluminum hydroxide.
Antacids are available over the counter and are taken by mouth to quickly relieve occasional heartburn, the major symptom of gastroesophageal reflux disease and also indigestion. Treatment with antacids alone is symptomatic and only justified for minor symptoms.[2]
Antacids are distinct from acid-reducing drugs like H2-receptor antagonists or proton pump inhibitors and they do not kill the bacteria Helicobacter pylori, which causes most ulcers.[2]
Side effects
Versions with magnesium may cause diarrhoea, and brands with calcium or aluminium may cause constipation and rarely, long-term use may cause kidney stones. Long term use of versions with aluminum may increase the risk for getting osteoporosis.[3]
Mechanism of action
When excessive amounts of acids are produced in the stomach the natural mucous barrier that protects the lining of the stomach can damage the esophagus in people with acid reflux. Antacids contain alkaline ions that chemically neutralize stomach gastric acid, reducing damage and relieving pain.[1]
Formulations
Antacids may be formulated with other active ingredients like simethicone to control gas or alginic acid to act as a physical barrier to acid.[4]
References
- ^ a b Internal Clinical Guidelines Team (UK). Dyspepsia and Gastro-Oesophageal Reflux Disease: Investigation and Management of Dyspepsia, Symptoms Suggestive of Gastro-Oesophageal Reflux Disease, or Both. London: National Institute for Health and Care Excellence (UK); 2014 Sep. PMID 25340236. Free full text
- ^ a b U.S. Department of Health & Human Services. Agency for Healthcare Research and Quality 23 September 2011 Consumer Summary – Treatment Options for GERD or Acid Reflux Disease: A Review of the Research for Adults
- ^ U.S. Department of Health and Human Services, National Institutes of Health, U.S. National Library of Medicine. Page last updated: 07 November 2014 Medline Plus: Taking Antacids
- ^ IFFGD. Antacids Adapted from IFFGD Publication #520 by W. Grant Thompson. Last modified on September 12, 2014
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Look up antacid in Wiktionary, the free dictionary. |
Drugs for acid related disorders: Antacids (A02A)
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Magnesium (increases motility) |
- Magnesium carbonate
- Magnesium oxide
- Magnesium peroxide
- Magnesium hydroxide
- Magnesium silicate
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Aluminium (decreases motility) |
- Aceglutamide aluminum
- Algeldrate
- Aluminium phosphate
- Aluminium acetoacetate
- Aloglutamol
- Aluminium glycinate
- Carbaldrate
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Calcium |
- Calcium carbonate
- Calcium silicate
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Sodium |
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Combinations and complexes
of aluminium, calcium and magnesium |
- Almagate
- Almasilate
- Hydrotalcite
- Magaldrate
|
UpToDate Contents
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English Journal
- Partnership in optimizing management of reflux symptoms: a treatment algorithm for over-the-counter proton-pump inhibitors.
- Boardman HF1, Delaney BC, Haag S.
- Current medical research and opinion.Curr Med Res Opin.2015 Jul;31(7):1309-18. doi: 10.1185/03007995.2015.1047745. Epub 2015 Jun 15.
- BACKGROUND: Uncomplicated heartburn and acid regurgitation are increasingly treated and managed using over-the-counter medications. However, with over-the-counter availability of antacids, alginates, histamine 2 receptor antagonists (H2RAs), and proton-pump inhibitors (PPIs), consumers need guidance
- PMID 25950642
- Safety of medication options for treating pediatric esophagitis.
- Bardou M1, Fortinsky KJ.
- Expert opinion on drug safety.Expert Opin Drug Saf.2015 Jul;14(7):1087-96. doi: 10.1517/14740338.2015.1040389. Epub 2015 Apr 26.
- INTRODUCTION: The management of gastro-esophageal reflux and esophagitis in infants and children is challenging, and there are currently no clear practice guidelines. Given a paucity of evidence in the treatment of pediatric esophagitis, there are concerns over both the efficacy and safety of proton
- PMID 25913014
- Meta-analysis of Antacid Use and Alzheimer Disease: Implications for the Aluminum Hypothesis.
- Virk SA1, Eslick GD.
- Epidemiology (Cambridge, Mass.).Epidemiology.2015 Jun 19. [Epub ahead of print]
- BACKGROUND: Exposure to aluminum remains a controversial risk factor for Alzheimer's disease. Antacids are aluminum-rich medications that are widely used in substantial amounts, but their association with Alzheimer's disease has not been systematically quantified.METHODS: We conducted electronic sea
- PMID 26098935
Japanese Journal
- Control of Constipation in Patients Receiving CHOP or CHOP-Like Chemotherapy Regimens for Non-Hodgkin's Lymphoma
- Etiology and Risk Factors of Acute Gastroenteritis in a Taipei Emergency Department: Clinical Features for Bacterial Gastroenteritis
- Etiology and Risk Factors of Acute Gastroenteritis in a Taipei Emergency Department: Clinical Features for Bacterial Gastroenteritis
Related Links
- Antacids neutralise the acid made by your stomach. They are commonly used in conditions where it is helpful to neutralise the acid made in the stomach.... ... Your stomach normally produces acid to help with the digestion of food ...
- Compare antacids. Includes user reviews and ratings for individual medications. Find related monographs and prescribing information. ... Drugs.com provides accurate and independent information on more than 24,000 prescription ...
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- 関
- antacidum