- 関
- anileridine
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/18 21:56:46」(JST)
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Anileridine
|
Systematic (IUPAC) name |
Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
|
Clinical data |
AHFS/Drugs.com |
monograph |
Legal status |
- AU: S8 (Controlled)
- CA: ℞-only
- DE: Anlage I
- US: Schedule II
|
Routes of
administration |
Tablets, injection |
Pharmacokinetic data |
Protein binding |
> 95% |
Metabolism |
Hepatic |
Identifiers |
CAS Number |
144-14-9 Y |
ATC code |
N01AH05 |
PubChem |
CID 8944 |
IUPHAR/BPS |
7115 |
DrugBank |
DB00913 Y |
ChemSpider |
8600 Y |
UNII |
71Q1A3O279 Y |
KEGG |
D02941 Y |
ChEBI |
CHEBI:61203 Y |
ChEMBL |
CHEMBL1201347 N |
Chemical data |
Formula |
C22H28N2O2 |
Molar mass |
352.47 g/mol |
SMILES
-
O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3
|
InChI
-
InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 Y
-
Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N Y
|
Physical data |
Melting point |
83 °C (181 °F) |
NY (what is this?) (verify) |
Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.
Anileridine is no longer manufactured in the US or Canada.[2]
Administration
As tablets or injection.[3]
Pharmacokinetics
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.
References
- ^ U.S. Patent 2,897,204
- ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
- ^ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
- ^ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.
General anesthetics (N01A)
|
|
Inhalational |
- Chloroethane (ethyl chloride)‡
- Chloroform‡
- Cyclopropane‡
- Desflurane
- Diethyl ether‡
- Enflurane
- Ethylene‡
- Fluroxene‡
- Halothane#
- Isoflurane
- Methoxyflurane
- Methoxypropane‡
- Nitrous oxide#
- Sevoflurane
- Trichloroethylene‡
- Vinyl ether‡
- Xenon
|
|
Injection |
Barbiturates |
- Hexobarbital
- Methohexital
- Narcobarbital
- Thiopental#
- Thiotetrabarbital
|
|
Opioids |
- Alfentanil
- Anileridine‡
- Fentanyl
- Phenoperidine
- Remifentanil
- Sufentanil
|
|
Arylcyclohexylamines |
- Esketamine
- Ketamine#
- Phencyclidine‡
- Tiletamine
|
|
Others |
- Alfadolone
- Alfaxalone
- Etomidate
- Fospropofol
- Hydroxydione
- GHB
- Metomidate
- Midazolam
- Propanidid‡
- Propofol
|
|
|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
Opioidergics
|
|
Receptor
(ligands) |
MOR |
|
|
DOR |
|
|
KOR |
- Agonists: 6'-GNTI
- 8-CAC
- 18-MC
- 14-Methoxymetopon
- β-Chlornaltrexamine
- β-Funaltrexamine
- Adrenorphin (metorphamide)
- Akuuamicine
- Alazocine
- Allomatrine
- Asimadoline
- BAM-12P
- BAM-18P
- BAM-22P
- Big dynorphin
- Bremazocine
- BRL-52537
- Butorphanol
- BW-373U86
- Cebranopadol
- Ciprefadol
- CR665
- Cyclazocine
- Cyclorphan
- Cyprenorphine
- Diamorphine (heroin)
- Diacetylnalorphine
- Difelikefalin
- Dihydroetorphine
- Dihydromorphine
- Dynorphin A
- Dynorphin B (rimorphin)
- Eluxadoline
- Enadoline
- Eptazocine
- Erinacine E
- Ethylketazocine
- Etorphine
- Fedotozine
- Fentanyl
- Gemazocine
- GR-89696
- GR-103545
- Hemorphin-4
- Herkinorin
- HS665
- Hydromorphone
- HZ-2
- Ibogaine
- ICI-199,441
- ICI-204,448
- Ketamine
- Ketazocine
- Laudanosine
- Leumorphin (dynorphin B-29)
- Levallorphan
- Levorphanol
- Lexanopadol
- Lofentanil
- LPK-26
- Lufuradom
- Matrine
- MB-1C-OH
- Menthol
- Metazocine
- Metkefamide
- Mianserin
- Mirtazapine
- Morphine
- Moxazocine
- MR-2034
- N-MPPP
- Nalbuphine
- NalBzOH
- Nalfurafine
- Nalmefene
- Nalorphine
- Naltriben
- Norbuprenorphine
- Norbuprenorphine-3-glucuronide
- Noribogaine
- Norketamine
- O-Desmethyltramadol
- Oripavine
- Oxilorphan
- Oxycodone
- Pentazocine
- Pethidine (meperidine)
- Phenazocine
- Proxorphan
- RB-64
- Salvinorin A (salvia)
- Salvinorin B ethoxymethyl ether
- Salvinorin B methoxymethyl ether
- SKF-10047
- Spiradoline (U-62,066)
- TH-030418
- Thienorphine
- Tifluadom
- Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
- U-50,488
- U-54,494A
- U-69,593
- Xorphanol
- Antagonists: 4′-Hydroxyflavanone
- 4',7-Dihydroxyflavone
- 5'-GNTI
- 6'-GNTI
- 6β-Naltrexol
- 6β-Naltrexol-d4
- β-Chlornaltrexamine
- Buprenorphine/samidorphan
- Amentoflavone
- ANTI
- Apigenin
- Arodyne
- AT-076
- Axelopran
- Binaltorphimine
- BU09059
- Buprenorphine
- Catechin
- Catechin gallate
- CERC-501 (LY-2456302)
- Clocinnamox
- Cyclofoxy
- Dezocine
- DIPPA
- Diprenorphine
- EGC
- ECG
- Epicatechin
- Hyperoside
- JDTic
- LY-255582
- LY-2196044
- LY-2459989
- LY-2795050
- MeJDTic
- Methylnaltrexone
- ML190
- ML350
- MR-2266
- N-Fluoropropyl-JDTic
- Naloxone
- Naltrexone
- Naltrindole
- Naringenin
- Norbinaltorphimine
- Noribogaine
- Pawhuskin A
- PF-4455242
- RB-64
- Quadazocine
- Taxifolin
- UPHIT
- Zyklophin
- Unknown/unsorted: Akuammicine
- Akuammine
- Coronaridine
- Cyproterone acetate
- Dihydroakuuamine
- Ibogamine
- Tabernanthine
|
|
NOP |
- Agonists: (Arg14,Lys15)Nociceptin
- ((pF)Phe4)Nociceptin(1-13)NH2
- (Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2
- Ac-RYYRWK-NH2
- Ac-RYYRIK-NH2
- BU08070
- Buprenorphine
- Cebranopadol
- Dihydroetorphine
- Etorphine
- JNJ-19385899
- Levorphanol
- Lexanopadol
- MCOPPB
- MT-7716
- NNC 63-0532
- Nociceptin (orphanin FQ)
- Nociceptin (1-11)
- Nociceptin (1-13)NH2
- Norbuprenorphine
- Ro64-6198
- Ro65-6570
- SCH-221510
- SCH-486757
- SR-8993
- SR-16435
- TH-030418
- Antagonists: (Nphe1)Nociceptin(1-13)NH2
- AT-076
- BAN-ORL-24
- J-113397
- JTC-801
- LY-2940094
- NalBzOH
- Nociceptin (1-7)
- Nocistatin
- SB-612111
- SR-16430
- Thienorphine
- Trap-101
- UFP-101
|
|
Unsorted /
unknown |
- β-Casomorphins
- Amidorphin
- BAM-20P
- Cytochrophin-4
- Deprolorphin
- Gliadorphin (gluteomorphin)
- Gluten exorphins
- Hemorphins
- Kava constituents
- MEAGL
- MEAP
- NEM
- Neoendorphins
- Peptide B
- Peptide E
- Peptide F
- Peptide I
- Rubiscolins
- Soymorphins
|
|
|
Enzyme
(inhibitors) |
Enkephalinase |
- Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
|
|
|
Others |
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
|
|
See also: Neuropeptidergics • Peptidergics
|
|
UpToDate Contents
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English Journal
- Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics.
- Sim E1, Dimoglo A, Shvets N, Ahsen V.
- Current medicinal chemistry.Curr Med Chem.2002 Aug;9(16):1537-45.
- Structure-activity relationships (SAR) are studied in the series of 4,4-disubstituted piperidine morphinomimetics (42 compounds) by means of the Electronic-Topological Method (ETM). In the frameworks of this approach, its input data were taken as the results of conformational and quantum-mechanical
- PMID 12171562
- Anileridine-induced delirium.
- Moss JH1.
- Journal of pain and symptom management.J Pain Symptom Manage.1995 May;10(4):318-20.
- Delirium is a common complication in hospitalized patients and is often associated with significant morbidity. It is important to recognize this syndrome early so that potential causes can be identified and properly managed. Although the etiology of delirium in critically or terminally ill patients
- PMID 7541439
- Clinical application of nebulized opioids for treatment of dyspnoea in patients with malignant disease.
- Farncombe M1, Chater S.
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.Support Care Cancer.1994 May;2(3):184-7.
- This article describes our experience in the clinical use of nebulized opioids for the management of dyspnoea in patients with terminal cancer by reviewing three specific patient case studies in which this treatment was found to be both safe and effective in controlling breathlessness. The patients
- PMID 7518312
Related Links
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★リンクテーブル★
[★]
- 英
- anileridine、anileridine hydrochloride
- 関
- 塩酸アニレリジン
[★]
- 英
- anileridine hydrochloride
- 関
- アニレリジン
[★]
アニレリジン
- 関
- anileridine hydrochloride
[★]
塩酸塩、ハイドロクロライド