WordNet

without water; especially without water of crystallization
a bitter alkaloid found in coffee and tea that is responsible for their stimulating effects (同)caffein

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1. カフェインの心血管系への影響 cardiovascular effects of caffeine
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Polymorphic transformation of anhydrous caffeine under compression and grinding: a re-evaluation.

Mazel V, Delplace C, Busignies V, Faivre V, Tchoreloff P, Yagoubi N.SourceEA 401 "Materiaux et Sante", UFR de Pharmacie, Universite Paris-sud 11, 5, avenue Jean Baptiste Clement, 92296 Chatenay Malabry Cedex, France.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.2011 Jul;37(7):832-40. Epub 2011 Jan 10.
Polymorphic transformations that may occur during mechanical treatment are of great interest for the production of pharmaceutical solids. Anhydrous caffeine is a well-known example of such transformations but a careful reading of the already existing literature shows that published results are contr
PMID 21214492

Low- and high-frequency Raman investigations on caffeine: polymorphism, disorder and phase transformation.

Hedoux A, Decroix AA, Guinet Y, Paccou L, Derollez P, Descamps M.SourceUniversite Lille Nord de France, F-59000 Lille, France.
The journal of physical chemistry. B.J Phys Chem B.2011 May 19;115(19):5746-53. Epub 2011 Apr 22.
Raman investigations are carried out both in crystalline forms of caffeine and during the isothermal transformation of the orientationally disordered form I into the stable form II at 363 K. The time dependence of the Raman spectrum exhibits no significant change in the intramolecular regime (above
PMID 21513330

Scale-Up Studies on High Shear Wet Granulation Process from Mini-Scale to Commercial Scale

AIKAWA Shouhei,FUJITA Naomi,MYOJO Hidetoshi,HAYASHI Takashi,TANINO Tadatsugu
Chemical & pharmaceutical bulletin 56(10), 1431-1435, 2008-10-01
… Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. …
NAID 110006936294

吉田幸恵,村山直也
アレルギー 56(10), 1298-1300, 2007-10-30
78歳,女性.咳,発熱あり近医受診し,レボフロキサシン,カルボシステイン,感冒薬(サリチルアミド,アセトアミノフェン,無水カフェイン,メチレンジサリチル酸プロメタジン)を処方された.その翌日より躯幹の紅斑が出現し,皮疹は拡大傾向を示した.間擦部を中心に毛孔非一致性の小膿庖が紅斑上に多数存在し,組織学的には角層下膿庖であった.3剤を中止し,一旦軽快するも,皮疹の再燃をみた.再度の問診にて,市販薬ケロ …
NAID 110006437785