angiotensin-converting enzyme antagonist

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  • The actions of the renin-angiotensin system on cardiovascular and osmoregulatory function in embryonic chickens (Gallus gallus domesticus).
  • Mueller CA1, Crossley DA 2nd2, Burggren WW2.
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2014 Dec;178:37-45. doi: 10.1016/j.cbpa.2014.08.004. Epub 2014 Aug 20.
  • Using embryonic chickens (Gallus gallus domesticus), we examined the role of the renin-angiotensin system (RAS) in cardiovascular and osmotic homeostasis through chronic captopril, an angiotensin-converting enzyme (ACE) inhibitor. Captopril (5mgkg(-1) embryo wet mass) or saline (control) was deliver
  • PMID 25149042
  • Modulation of the kallikrein/kinin system by the angiotensin-converting enzyme inhibitor alleviates experimental autoimmune encephalomyelitis.
  • Uzawa A1, Mori M, Taniguchi J, Kuwabara S.
  • Clinical and experimental immunology.Clin Exp Immunol.2014 Nov;178(2):245-52. doi: 10.1111/cei.12413.
  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Bradykinin is the end-product of the kallikrein/kinin system, which has been recognized as an endogenous target for combating CNS inflammation. Angiotensin-converting enzyme (ACE) inhibitors influence the
  • PMID 24996009
  • Effect of extended follow-up in a specialized heart failure clinic on adherence to guideline recommended therapy: NorthStar Adherence Study.
  • Schou M1, Gislason G, Videbaek L, Kober L, Tuxen C, Torp-Pedersen C, Hildebrandt PR, Gustafsson F; on behalf of the NorthStar Investigators.
  • European journal of heart failure.Eur J Heart Fail.2014 Oct 14. doi: 10.1002/ejhf.176. [Epub ahead of print]
  • AIMS: The optimal duration of a public heart failure (HF) clinic programme is unknown. This substudy of the NT-proBNP stratified follow-up in outpatient heart failure clinics (NorthStar) trial was designed to evaluate the effect of extended follow-up in an outpatient HF clinic on long-term adherence
  • PMID 25311554



ACE inhibitors possess many common characteristics with another class of cardiovascular drugs, angiotensin II receptor antagonists, which are often used when patients are intolerant ...


 photos for Angiotensin Converting Enzyme(ARBs) and angiotensin-converting enzyme DRIICKY GRAHAM LETTER TO MY SON DOWNLOADangiotensin i converting enzymes in clam 147825.fig.003 angiotensin converting enzyme (ACE




angiotensin-converting enzyme inhibitor angiotensin converting enzyme inhibitor , ACE inhibitor, ACEI
アンジオテンシン変換酵素阻害剤 アンギオテンシン変換酵素阻害薬 アンギオテンシン変換酵素阻害剤 アンジオテンシン転換酵素阻害薬ACE阻害薬 ACE阻害剤 ACE inhibitor、アンギオテンシン変換酵素拮抗薬, アンギオテンシン変換酵素拮抗薬, angiotensin-converting enzyme antagonist
アンジオテンシン, アンジオテンシン転換酵素 ACE, 1型アンジオテンシンII受容体拮抗薬



  • 咳嗽:ACEブラジキニンを分解するキニナーゼIIと同一の酵素である。ACE阻害薬はこの酵素を阻害するが、ブラジキニンは血管拡張、血漿滲出、発痛作用に関わっている。このため咳を誘発することがある。
  • 高カリウム血症:間接的に血漿中のレニン濃度が低下するためにナトリウム取り込みとカリウム排泄が低下して高カリウム血症を来す
  • 低血圧
  • 腎不全


  • 妊婦
  • 両側性腎動脈狭窄のある患者
  • 腎血流量の減少や糸球体ろ過圧の低下により急速に腎機能を悪化させるおそれ。アンジオテンシンIIによる輸出細動脈の収縮作用がblockされ、両腎共に腎血流が減少しているためにGFRの低下を代償できず腎機能の悪化をきたす。




  [★] 拮抗薬

WordNet   license wordnet

「a drug that neutralizes or counteracts the effects of another drug」

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「a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"」

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  [★] 酵素

WordNet   license wordnet

「any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions」

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  [★] アンジオテンシン

WordNet   license wordnet

「any of several vasoconstrictor substances (trade name Hypertensin) that cause narrowing of blood vessels」
angiotonin, Hypertensin