関: anetholtrithion

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/11/05 23:40:44」(JST)

wiki en

Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer.^[1] Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative.

Brand names

Felviten
Halpen
Hepasulfol - Franco-Indian Pharmaceuticals
Heporal
Mucinol - Sanofi-Aventis
Sialor - Paladin Laboratories; Pharmascience; Solvay; Zuoz Pharma
Sonicur - Solvay
Sulfarlem - Solvay; Aguettant; Edward Keller; Sanofi-Aventis
Sulfarlem S - EG Labo
Tiopropen
Tiotrifar

References

^ Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved September 13, 2008.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome
2. 肺癌の化学予防 chemoprevention of lung cancer

English Journal

An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.

Yu HZ, Han SF, Li P, Zhu CL, Zhang XX, Gan L, Gan Y.SourceShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Journal of pharmaceutical sciences.J Pharm Sci.2011 Nov;100(11):5048-58. doi: 10.1002/jps.22702. Epub 2011 Jul 15.
In this study, an examination of the potential effect of lipids on the first-pass metabolism of anethol trithione (ATT) was investigated. ATT is metabolized rapidly and extensively in liver into 4-hydroxy-anethole trithione (ATX), which was confirmed using the rat intestinal perfusion with the mesen
PMID 21766311

An HPLC-MS/MS method for the quantitative determination of 4-hydroxy-anethole trithione in human plasma and its application to a pharmacokinetic study.

He J, Qin T, Wen J, Qin F, Li F.SourceDepartment of Analytical Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Feb 20;54(3):551-6. doi: 10.1016/j.jpba.2010.09.037. Epub 2010 Oct 8.
A selective, rapid and sensitive method for the quantitation of 4-hydroxy-anethole trithione (ATX) in human plasma based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. Paracetamol was used as the internal standard (I.S.). After liquid-liq
PMID 20980118

Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity.

Chen P, Luo Y, Hai L, Qian S, Wu Y.SourceWest China School of Pharmacy, Sichuan University, Chengdu 610041, China.
European journal of medicinal chemistry.Eur J Med Chem.2010 Jul;45(7):3005-10. doi: 10.1016/j.ejmech.2010.03.029. Epub 2010 Mar 25.
A metabolite-based prodrug strategy to increase the solubility of anethole trithione was reported to facilitate the clinical application of this hepatoprotective agent. Water-soluble analogs of anethole trithione were synthesized via substituting the methyl group of anethole trithione with the simpl
PMID 20392547

Japanese Journal

シェーグレン症候群に伴う口腔乾燥症に対する塩酸ピロカルピンの有効性

岩渕博史,岩渕絵美,内山公男
日本口腔粘膜学会雑誌 = Journal of Japanese Society for Oral Mucous Membrane 14(2), 31-38, 2008-12-30
シェーグレン症候群（以下SS）に伴う口腔乾燥症の治療薬として新規承認された塩酸ピロカルピンの投与効果および副作用について検討した。対象は2007年10月～2008年5月までに本剤を投与した症例中，塩酸セビメリンやアネトールトリチオンによる治療歴がなく投与4週後の評価が行えた30例である。10分間ガムテスト値は投与前に比べ投与開始4週後以降では有意に増加したが，自覚症状スコアでは有意な …
NAID 10025567720

唾液分泌低下-その原因と唾液分泌低下に伴う口腔障害

植田栄作,木村剛,谷田豊宏,岡本哲郎,岡本敦子,森仁志,山本哲也,尾崎登喜雄
日本口腔科学会雜誌 52(5), 227-234, 2003-09-10
NAID 10014354043

Enhancement of salivary secretion and neuropeptide (substance P, α-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment

NAGANO T.
J. Pharm. Pharmacol. 53, 1697-1702, 2001
NAID 80012884651

「アネトールトリチオン」

Anethole trithione
Clinical data
ATC code	A16AX02 (WHO) ;
Identifiers
	IUPAC name 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione;
CAS Number	532-11-6 ;
PubChem CID	2194;
ChemSpider	2109 ;
KEGG	D01584 ;
ChEMBL	ChEMBL178862 ;
CompTox Dashboard (EPA)	DTXSID9046651 ;
ECHA InfoCard	100.007.754
Chemical and physical data
Formula	C10H8OS3
Molar mass	240.365 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES S=C\2SS/C(c1ccc(OC)cc1)=C/2;
	InChI InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3 ; Key:KYLIZBIRMBGUOP-UHFFFAOYSA-N ;
(verify)

　　[★]

英: anethole trithione、anetholtrithion
商: アテネントール、フェルビテン

「anetholtrithion」

　　[★]

アネトールトリチオン

関: anethole trithione

[1] Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved September 13, 2008.

v t e Other alimentary tract and metabolism products (A16)
Amino acids and derivatives	Ademetionine Betaine Carglumic acid Cysteamine Levocarnitine Levoglutamide Metreleptin
Enzymes	Carbohydrate metabolism: sucrase (Sacrosidase) alpha-glucosidase (Alglucosidase alfa) Glycolipid/sphingolipid: glucocerebrosidase (Alglucerase Imiglucerase Taliglucerase alfa Velaglucerase alfa) alpha-galactosidase (Agalsidase alfa Agalsidase beta) Glycosaminoglycan: iduronidase (Laronidase) arylsulfatase B (Galsulfase) iduronate-2-sulfatase (Idursulfase) Lipid: lysosomal lipase (Sebelipase alfa) Phosphate: Asfotase alfa
Other	Anethole trithione Eliglustat Glycerol phenylbutyrate Miglustat Nitisinone Sapropterin Sodium benzoate Sodium phenylbutyrate Teduglutide Trientine Tioctic acid Uridine triacetate Zinc acetate

匿名

検索

案内

案内

anethole trithione