WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- male sex hormone that is produced in the testes and responsible for typical male sexual characteristics (同)androgenic_hormone
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 蛋白(たんばく)質
- アンドロゲン(男性ホルモン)
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/22 23:24:52」(JST)
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- 1. 男性生殖生理学 male reproductive physiology
- 2. 思春期における多嚢胞性卵巣症候群の治療 treatment of polycystic ovary syndrome in adolescents
English Journal
- Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression.
- Liu Q1, Wang Y1, Gu J1, Yuan Y1, Liu X1, Zheng W1, Huang Q1, Liu Z1, Bian J2.Author information 1College of Veterinary Medicine, Yangzhou University, 12 East, Wenhui Road, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.2College of Veterinary Medicine, Yangzhou University, 12 East, Wenhui Road, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address: jcbian@yzu.edu.cn.AbstractZearalenone (ZEA) directly inhibits testosterone biosynthesis in Leydig cells, although the mechanisms involved remains unclear. Various experiments were performed to elucidate the molecular pathway of ZEA-mediated androgen inhibition. Leydig cells were isolated from 6week-old male ICR mice and subjected to ZEA pre-treatment. The levels of testosterone and a series of influncing factors were measured. The results showed that ZEA caused a concentration- and time-dependent inhibition of testosterone stimulated both by hCG and cAMP (P<0.05). Exposure to ZEA did not affect the LHR binding activity nor the protein expression (P>0.05). However, ZEA exposure significantly elevated the cellular cAMP levels (P<0.05) in low concentrations (5μg/ml) or for long time periods (24h), significantly reduce the mitochondrial membrane potential (P<0.05). The expression of P450scc, 17β-HSD, and P450c17 at the mRNA level were significantly decreased (P<0.05). The steroidogenic acute regulatory (StAR) and 3β-HSD expression was significantly increased (P<0.05). Furthermore, the ERα protein expression was not affected by ZEA, but Nur77 expression was significantly inhibited (P<0.05). These observations imply that ZEA activity interferes with testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and Nur77 expression.
- Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Jun;28(4):647-56. doi: 10.1016/j.tiv.2014.01.013. Epub 2014 Feb 7.
- Zearalenone (ZEA) directly inhibits testosterone biosynthesis in Leydig cells, although the mechanisms involved remains unclear. Various experiments were performed to elucidate the molecular pathway of ZEA-mediated androgen inhibition. Leydig cells were isolated from 6week-old male ICR mice and subj
- PMID 24512812
- Wild fish from the Bay of Quinte Area of Concern contain elevated tissue concentrations of PCBs and exhibit evidence of endocrine-related health effects.
- Simmons DB1, McMaster ME1, Reiner EJ2, Hewitt LM1, Parrott JL1, Park BJ3, Brown SB1, Sherry JP1.Author information 1Aquatic Contaminants Research Division, Environment Canada, National Water Research Institute, Burlington, ON, Canada.2Laboratory Services Branch, Ontario Ministry of the Environment, Toronto, ON, Canada.3Freshwater Institute, Fisheries and Oceans Canada, Winnipeg, MB, Canada.AbstractThe Bay of Quinte (BOQ) is an Area of Concern listed under the Great Lakes Water Quality Agreement. The presence of dioxins and dioxin-like PCBs in fish in the BOQ AOC has led to restrictions on fish consumption by humans, which is a beneficial use impairment. Adult yellow perch (Perca flavescens) and brown bullhead (Ameiurus nebulosus) were sampled from Trenton, Belleville, and Deseronto (reference site) in the BOQ. A suite of hormone assays and various measures of exposure and/or sublethal health effects were used to assess the health status of fish of both species and sex. Condition factor, hepatosomatic index, ethoxyresorufin-O-deethylase activity, circulating steroid and thyroid hormones, thyroid activation, oocyte size distribution, spermatogenic cell stages, and plasma vitellogenin were among the endpoints that were significantly (p<0.05) affected by location. Many of those effects corresponded with significantly (p<0.05) greater tissue concentrations of polychlorinated biphenyls (PCBs) at Belleville and Trenton. Hepatic extracts from brown bullhead sampled from Trenton had significantly (p<0.05) greater binding activity to the androgen receptor and sex steroid binding protein. Taken together, these data and preliminary data from a concomitant study suggest that PCBs are likely being hydroxylated in vivo, resulting in enhanced bioactivity at endocrine receptors and measurable health responses. The present study supports the growing body of evidence that PCBs and their metabolites can affect fish thyroid and steroid hormone systems.
- Environment international.Environ Int.2014 May;66:124-37. doi: 10.1016/j.envint.2014.01.009. Epub 2014 Feb 25.
- The Bay of Quinte (BOQ) is an Area of Concern listed under the Great Lakes Water Quality Agreement. The presence of dioxins and dioxin-like PCBs in fish in the BOQ AOC has led to restrictions on fish consumption by humans, which is a beneficial use impairment. Adult yellow perch (Perca flavescens) a
- PMID 24576942
- Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells.
- Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, Gladkich J, Schönsiegel F, Herr I.Author information Experimental Surgery, General, Visceral and Transplantation Surgery, University of Heidelberg, D-69120 Heidelberg, Germany.AbstractAdvanced androgen-independent prostate cancer (AIPC) is an aggressive malignancy with a poor prognosis. Apoptosis-resistant cancer stem cells (CSCs) have been identified in AIPC and are not eliminated by current therapeutics. Novel therapeutic options, which are currently being evaluated in patient studies, include TRAIL and the broccoli-derived isothiocyanate sulforaphane. Although neither agent targets normal cells, TRAIL induces apoptosis in most cancer cells, and sulforaphane eliminates CSCs. In this study, the established AIPC cell lines DU145 and PC3, with enriched CSC features, and primary patient-derived prostate CSCs were treated with sulforaphane and recombinant soluble TRAIL. We examined the effects of these drugs on NF-κB activity, self-renewal and differentiation potential, and stem cell signaling via spheroid- and colony-forming assays, FACS and western blot analyses, immunohistochemistry, and an antibody protein array in vitro and after xenotransplantation. We largely found a stronger effect of sulforaphane on CSC properties compared to TRAIL, though the agents acted synergistically when applied in combination. This was associated with the inhibition of TRAIL-induced NF-κB binding; CXCR4, Jagged1, Notch 1, SOX 2, and Nanog expression; ALDH1 activity inhibition; and the elimination of differentiation and self-renewal potential. In vivo, tumor engraftment and tumor growth were strongly inhibited, without the induction of liver necrosis or other obvious side effects. These findings suggest that sulforaphane shifts the balance from TRAIL-induced survival signals to apoptosis and thus explains the observed synergistic effect. A nutritional strategy for high sulforaphane intake may target the cancer-specific activity of TRAIL in CSCs.
- International journal of oncology.Int J Oncol.2014 May;44(5):1470-80. doi: 10.3892/ijo.2014.2335. Epub 2014 Mar 10.
- Advanced androgen-independent prostate cancer (AIPC) is an aggressive malignancy with a poor prognosis. Apoptosis-resistant cancer stem cells (CSCs) have been identified in AIPC and are not eliminated by current therapeutics. Novel therapeutic options, which are currently being evaluated in patient
- PMID 24626333
Japanese Journal
- MS2-3 Endocrine disruption of androgen receptor (AR) and androgen binding protein (ABP) expression in adult testis
- Suarez-Quian Carlos A.,Tirado Oscar M.,Selva David M.,Reventos Jaume,Munell Francina
- Acta histochemica et cytochemica 35(3), 212, 2002
- NAID 110003151094
- Point Mutations in the Steroid-Binding Domain of the Androgen Receptor Gene of Five Japanese Patients with Androgen Insensitivity Syndrome.
- , , , , , , ,
- The Tohoku Journal of Experimental Medicine 187(3), 263-272, 1999
- … We analyzed the androgen receptor (AR) gene in five Japanese patients diagnosed with androgen insensitivity syndrome (AIS). … All the mutations occurred in the steroid-binding domain, comprising exons D through G. … Pubic skin fibroblasts from four of the five patients did not show detectable androgen binding. …
- NAID 130004821831
- ラット精細管および精巣上体管における経上皮性アンドロゲン移行に関する研究
- 山本 雅憲,日比 初紀,三宅 弘治
- 泌尿器科紀要 41(2), 119-125, 1995-02
- … The intraluminal 3H-androgen concentration in the seminiferous tubules increased linearly as the interstitial 3H-androgen concentrations increased from 10 nM to 2,000 nM, but in the caput epididymidal tubules, the intraluminal 3H-androgen concentration increased hyperbolically across the same range of peritubular 3H-androgen concentration. …
- NAID 120002156465
Related Links
- Define Androgen binding protein. Androgen binding protein synonyms, Androgen binding protein pronunciation, Androgen binding protein translation, English dictionary definition of Androgen binding protein. n. A steroid hormone ...
- Androgen binding protein information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Androgen binding protein Description of Androgen binding protein Androgen ...
Related Pictures
★リンクテーブル★
| リンク元 | 「セルトリ細胞」「アンドロゲン結合蛋白質」「アンドロゲン結合タンパク質」 |
| 関連記事 | 「binding」「binding protein」 |
「セルトリ細胞」
発生
- 由来：精巣の表面上皮(L.305)
機能 (HIS.416)
- 精子形成細胞の機械的支持や保護、栄養補給
- 精子発生の過程で除去された細胞質の食作用
- 隣接するセルトリ細胞どうして密着帯を形成し、血液精巣関門を形成する
- アンドロゲン結合蛋白 androgen-binding protein ABPの合成と分泌
- ミュラー管の形成を抑制し発生する胚子の男性を確立する抗ミュラー管ホルモンの合成と分泌(胚子発生の時期のみ
- 下垂体前葉からの卵胞刺激ホルモン(FSH)の分泌を抑制するインヒビンの合成と分泌
- 精子を栄養し、精巣から精子の輸送を促進するフルクトースに富んだ液の分泌
- 血清トランスフェリンから鉄を受け取り、それを成熟しつつある精子に渡すアポ蛋白である精巣トランスフェリンの合成と分泌
「アンドロゲン結合蛋白質」
- 英
- androgen-binding protein, ABP
- 関
- [[]]
機能
「アンドロゲン結合タンパク質」
「binding」
- n.
- adj.
- 結合性の
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union