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  • Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
  • Qin M1, Zeidler Z1, Moulton K1, Krych L1, Xia Z1, Smith CB2.
  • Behavioural brain research.Behav Brain Res.2015 Sep 15;291:164-71. doi: 10.1016/j.bbr.2015.05.003. Epub 2015 May 12.
  • Silencing the gene FMR1 in fragile X syndrome (FXS) with consequent loss of its protein product, FMRP, results in intellectual disability, hyperactivity, anxiety, seizure disorders, and autism-like behavior. In a mouse model (Fmr1 knockout (KO)) of FXS, a deficit in performance on the passive avoida
  • PMID 25979787
  • Anandamide restricts uterine stromal differentiation and is critical for complete decidualization.
  • Fonseca BM1, Correia-da-Silva G1, Teixeira NA2.
  • Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Aug 15;411:167-76. doi: 10.1016/j.mce.2015.04.024. Epub 2015 May 7.
  • The major endocannabinoid, anandamide (AEA), is widely distributed in the body, especially in the reproductive tissues, where it is implicated in early pregnancy events, particularly during implantation period. Although AEA is synthesized in decidual cells and showed to induce apoptosis through CB1
  • PMID 25960165
  • Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species.
  • Park SW1, Kim JE1, Oh SM1, Cha WJ2, Hah JH1,2,3, Sung MW1,2,3,4.
  • Head & neck.Head Neck.2015 Aug;37(8):1187-92. doi: 10.1002/hed.23727. Epub 2014 Jul 11.
  • BACKGROUND: The endocannabinoids, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), are considered promising potential anticancer agents. In this study, we examined the anticancer effects of AEA and 2-AG in head and neck squamous cell carcinoma (HNSCC) cell lines.METHODS AND RESULTS: Our results
  • PMID 24797795


  • Endocannabinoid-mediated retrograde modulation of synaptic transmission
  • Ohno-Shosaku Takako,Kano Masanobu
  • Current Opinion in Neurobiology 29(xxx), xx-xx, 2014-12
  • … Whereas 2-AG primarily transmits a rapid, transient, point-to-point retrograde signal, the other major endocannabinoid, anandamide, may function as a relatively slow retrograde or non-retrograde signal or as an agonist of the vanilloid receptor. …
  • NAID 120005435504
  • Control of synaptic function by endocannabinoid-mediated retrograde signaling
  • KANO Masanobu
  • Proceedings of the Japan Academy. Ser. B, Physical and Biological Sciences 90(7), 235-250, 2014-07
  • NAID 40020185495
  • アナンダミドと関連N-アシルエタノールアミン (第5土曜特集 生命を支える脂質 : 最新の研究と臨床) -- (脂質メディエーターと受容体・産生酵素)
  • 宇山 徹,上田 夏生
  • 医学のあゆみ 248(13), 1003-1008, 2014-03-29
  • NAID 40020026544


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