WordNet
- a substance from which another substance is formed (especially by a metabolic reaction)
- a person who goes before or announces the coming of another (同)forerunner
- (pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue
- a non-nitrogenous food substance consisting chiefly of starch; any substance resembling starch
PrepTutorEJDIC
- (…の)前朕,前触れ《+『of』+『名』》
UpToDate Contents
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English Journal
- Amplified voltammetric characterization of cleavage of the biotinylated peptide by BACE1 and screening of BACE1 inhibitors.
- Yi X, Han H, Zhang Y, Wang J, Zhang Y, Zhou F.SourceCollege of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, People's Republic of China.
- Biosensors & bioelectronics.Biosens Bioelectron.2013 Dec 15;50:224-8. doi: 10.1016/j.bios.2013.06.047. Epub 2013 Jul 2.
- Cleavage of amyloid precursor protein (APP) by the β-site APP cleaving enzyme 1 (BACE1) is a key step in the formation of amyloid beta (Aβ) peptide, the main component of amyloid plaques in Alzheimer's disease (AD). Suppression of BACE1 activity has thus become an efficient way for the treatment o
- PMID 23867352
- Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice.
- Paganetti P, Reichwald J, Bleckmann D, Abramowski D, Ammaturo D, Barske C, Danner S, Molinari M, Müller M, Papin S, Rabe S, Schmid P, Staufenbiel M.SourceNovartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: paganepa@bluewin.ch.
- Neurobiology of aging.Neurobiol Aging.2013 Dec;34(12):2866-78. doi: 10.1016/j.neurobiolaging.2013.06.013. Epub 2013 Jul 17.
- Heterologous expression of the functional amyloid beta (Aβ) antibody β1 in the central nervous system was engineered to maximize antibody exposure in the brain and assess the effects on Aβ production and accumulation in these conditions. A single open reading frame encoding the heavy and light ch
- PMID 23870837
- Cellular prion protein modulates β-amyloid deposition in aged APP/PS1 transgenic mice.
- Ordóñez-Gutiérrez L, Torres JM, Gavín R, Antón M, Arroba-Espinosa AI, Espinosa JC, Vergara C, Del Río JA, Wandosell F.SourceCentro de Biología Molecular "Severo Ochoa", Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
- Neurobiology of aging.Neurobiol Aging.2013 Dec;34(12):2793-804. doi: 10.1016/j.neurobiolaging.2013.05.019. Epub 2013 Jul 4.
- Alzheimer's disease and prion diseases are neuropathological disorders that are caused by abnormal processing and aggregation of amyloid and prion proteins. Interactions between amyloid precursor protein (APP) and PrP(c) proteins have been described at the neuron level. Accordingly to this putative
- PMID 23831375
Japanese Journal
- An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
- Kizuka Yasuhiko,Kitazume Shinobu,Fujinawa Reiko,Saito Takashi,Iwata Nobuhisa,Saido Takaomi C.,Nakano Miyako,Yamaguchi Yoshiki,Hashimoto Yasuhiro,Staufenbiel Matthias,Hatsuta Hiroyuki,Murayama Shigeo,Manya Hiroshi,Endo Tamao,Taniguchi Naoyuki
- EMBO Molecular Medicine 7(2), 175-189, 2015-02-01
- … The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). … Analysis of knockout mice lacking the biosynthetic enzyme for bisecting GlcNAc, GnT-III (Mgat3), revealed that cleavage of Aβ-precursor protein (APP) by BACE1 is reduced in these mice, resulting in a decrease in Aβ plaques and improved cognitive function. …
- NAID 120005549837
- Cytoplasmic Fragment of Alcadein alpha Generated by Regulated Intramembrane Proteolysis Enhances Amyloid beta-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage
- Takei Norio,Sobu Yuriko,Kimura Ayano,Urano Satomi,Piao Yi,Araki Yoichi,Taru Hidenori,Yamamoto Tohru,Hata Saori,Nakaya Tadashi,Suzuki Toshiharu
- Journal of biological chemistry 290(2), 987-995, 2015-01-09
- … The neural type I membrane protein Alcadein alpha (Alc alpha), is primarily cleaved by amyloid beta-protein precursor (APP) alpha-secretase to generate a membrane-associated carboxyl-terminal fragment (Alc alpha CTF), which is further cleaved by gamma-secretase to secrete p3-Alc alpha peptides and generate an intracellular cytoplasmic domain fragment (Alc alpha ICD) in the late secretory pathway. …
- NAID 120005567733
- A Second Pedigree with Amyloid-less Familial Alzheimer's Disease Harboring an Identical Mutation in the Amyloid Precursor Protein Gene (E693delta)
- , , , , , , , ,
- Internal Medicine 54(2), 205-208, 2015
- … positron emission tomography (PET) imaging revealed a large reduction in the level of glucose uptake without amyloid deposition in the cerebral cortex. … We identified a homozygous microdeletion within the amyloid β (Aβ) coding sequence in the amyloid precursor protein (APP) gene (c.2080_2082delGAA, p.E693del) in three affected siblings and a heterozygous microdeletion in an unaffected sibling. …
- NAID 130004903009
Related Links
- Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, ...
★リンクテーブル★
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アミロイド前駆タンパク質セクレターゼ、アミロイド前駆タンパク質分泌酵素
- 関
- alpha-secretase、beta-secretase、gamma-secretase、secretase
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アミロイド前駆体蛋白質遺伝子
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アミロイド前駆体蛋白質 APP
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アミロイド前駆体蛋白質
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- 関
- progenitor
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アミロイド
- 関
- amyloid fibril、amyloid protein