WordNet

invest with or as with a body; give body to (同)personify
the external structure of a vehicle; "the body of the car was badly rusted"
the main mass of a thing
a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
the central message of a communication; "the body of the message was short"
volcanic rock in which rounded cavities formed by expanding gas have subsequently become filled with mineral deposits

PrepTutorEJDIC

〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
《英話》人;(特に)男

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/05 09:05:53」(JST)

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Human brain in the coronal orientation. Amygdalae are shown in dark red.

The amygdalae (singular: amygdala; /əˈmɪɡdələ/; also corpus amygdaloideum; Latin, from Greek ἀμυγδαλή, amygdalē, 'almond', 'tonsil'^[1]), listed in the Gray's Anatomy textbook as the nucleus amygdalæ, are almond-shaped groups of nuclei located deep and medially within the temporal lobes of the brain in complex vertebrates, including humans.^[2] Shown in research to perform a primary role in the processing of memory, decision-making, and emotional reactions, the amygdalae are considered part of the limbic system.^[3]

1 Structure
- 1.1 Hemispheric specializations
- 1.2 Sex differences
2 Function
- 2.1 Connections
- 2.2 Emotional learning
- 2.3 Memory modulation
3 Neuropsychological correlates of amygdala activity
- 3.1 Sexual orientation
- 3.2 Social interaction
- 3.3 Aggression
- 3.4 Fear
- 3.5 Alcoholism and binge drinking
- 3.6 Anxiety
- 3.7 Posttraumatic Stress Disorder
4 See also
5 References
6 External links

Structure

The regions described as amygdala nuclei encompass several structures with distinct connectional and functional characteristics in humans and other animals.^[4] Among these nuclei are the basolateral complex, the cortical nucleus, the medial nucleus, the central nucleus, and the intercalated cell clusters (ITCs). The basolateral complex can be further subdivided into the lateral, the basal, and the accessory basal nuclei.^[3]^[5]^[6]

MRI coronal view of the left amygdala

Anatomically, the amygdala^[7] and more particularly, its central and medial nuclei,^[8] have sometimes been classified as a part of the basal ganglia.

Hemispheric specializations

There are functional differences between the right and left amygdala. In one study, electrical stimulations of the right amygdala induced negative emotions, especially fear and sadness. In contrast, stimulation of the left amygdala was able to induce either pleasant (happiness) or unpleasant (fear, anxiety, sadness) emotions.^[9] Other evidence suggests that the left amygdala plays a role in the brain's reward system.^[10]

Sex differences

The amygdala is one of the most well understood brain regions with regard to differences between the sexes. Larger male than female amygdalae have been demonstrated in children ages 7–11,^[11] in adult humans,^[12] and in adult rats.^[13]

In addition to size, other differences between men and women exist with regards to the amygdala. Subjects' amygdala activation was observed when watching a horror film. The results of the study showed a different lateralization of the amygdala in men and women. Enhanced memory for the film was related to enhanced activity of the left, but not the right, amygdala in women, whereas it was related to enhanced activity of the right, but not the left, amygdala in men.^[14] One study found evidence that on average, women tend to retain stronger memories for emotional events than men. ^[15]

The right amygdala is also linked with taking action as well as being linked to negative emotions,^[16] which may help explain why males tend to respond to emotionally stressful stimuli physically. The left amygdala allows for the recall of details, but it also results in more thought rather than action in response to emotionally stressful stimuli, which may explain the lack of physical response in women.

Function

Connections

The amygdala sends projections to the hypothalamus, the dorsomedial thalamus, the thalamic reticular nucleus, the nuclei of the trigeminal nerve and the facial nerve, the ventral tegmental area, the locus coeruleus, and the laterodorsal tegmental nucleus.^[5]

Coronal section of brain through intermediate mass of third ventricle. Amygdala is shown in purple.

The medial nucleus is involved in the sense of smell and pheromone-processing. It receives input from the olfactory bulb and olfactory cortex.^[17] The lateral amygdalae, which send impulses to the rest of the basolateral complexes and to the centromedial nuclei, receive input from the sensory systems. The centromedial nuclei are the main outputs for the basolateral complexes, and are involved in emotional arousal in rats and cats.^[5]^[6]^[18]

Emotional learning

In complex vertebrates, including humans, the amygdalae perform primary roles in the formation and storage of memories associated with emotional events. Research indicates that, during fear conditioning, sensory stimuli reach the basolateral complexes of the amygdalae, particularly the lateral nuclei, where they form associations with memories of the stimuli. The association between stimuli and the aversive events they predict may be mediated by long-term potentiation, a sustained enhancement of signaling between affected neurons.^[3] There have been studies that show that damage to the amygdala can interfere with memory that is strengthened by emotion. One study examined a patient with bilateral degeneration of the amygdala. He was told a violent story accompanied by matching pictures and was observed based on how much he could recall from the story. The patient had less recollection of the story than patients without amygdala damage, showing that the amygdala has a strong connection with emotional learning.^[19]

Memories of emotional experiences imprinted in reactions of synapses in the lateral nuclei elicit fear behavior through neuronal connections with the central nucleus of the amygdalae and the bed nuclei of the stria terminalis (BNST). The axon terminals from sensory neurons form synapses with dendritic spines on neurons from the central nucleus.^[20] The central nuclei are involved in the genesis of many fear responses such as defensive behavior (freezing or escape responses), autonomic nervous system responses (changes in blood pressure and heart rate/tachycardia), neuroendocrine responses (stress-hormone release), etc. Damage to the amygdalae impairs both the acquisition and expression of Pavlovian fear conditioning, a form of classical conditioning of emotional responses.^[3]

The amygdalae are also involved in appetitive (positive) conditioning. It seems that distinct neurons respond to positive and negative stimuli, but there is no clustering of these distinct neurons into clear anatomical nuclei.^[21] However, lesions of the central nucleus in the amygdala have been shown to reduce appetitive learning in rats. Lesions of the basolateral regions do not exhibit the same effect.^[22] Research like this indicates that different nuclei within the amygdala have different functions in appetitive conditioning.^[23]

Memory modulation

The amygdala is also involved in the modulation of memory consolidation. Following any learning event, the long-term memory for the event is not formed instantaneously. Rather, information regarding the event is slowly assimilated into long-term (potentially lifelong) storage over time, possibly via long-term potentiation. Recent studies suggest that, while the amygdala is not itself a long-term memory storage site, and learning can occur without it, one of its roles is to regulate memory consolidation in other brain regions.^[24] Also, fear conditioning, a type of memory that is impaired following amygdala damage, is mediated in part by long-term potentiation.^[25]^[26]

During the consolidation period, the memory can be modulated. In particular, it appears that emotional arousal following the learning event influences the strength of the subsequent memory for that event. Greater emotional arousal following a learning event enhances a person's retention of that event. Experiments have shown that administration of stress hormones to mice immediately after they learn something enhances their retention when they are tested two days later.^[27]

The amygdala, especially the basolateral nuclei, are involved in mediating the effects of emotional arousal on the strength of the memory for the event, as shown by many laboratories including that of James McGaugh. These laboratories have trained animals on a variety of learning tasks and found that drugs injected into the amygdala after training affect the animals' subsequent retention of the task. These tasks include basic classical conditioning tasks such as inhibitory avoidance, where a rat learns to associate a mild footshock with a particular compartment of an apparatus, and more complex tasks such as spatial or cued water maze, where a rat learns to swim to a platform to escape the water. If a drug that activates the amygdalae is injected into the amygdalae, the animals had better memory for the training in the task.^[28] If a drug that inactivates the amygdalae is injected, the animals had impaired memory for the task.

Buddhist monks who do compassion meditation have been shown to modulate their amygdala, along with their temporoparietal junction and insula, during their practice.^[29] In an fMRI study, more intensive insula activity was found in expert meditators than in novices.^[30] Increased activity in the amygdala following compassion-oriented meditation may contribute to social connectedness.^[31]

Amygdala activity at the time of encoding information correlates with retention for that information. However, this correlation depends on the relative "emotionalness" of the information. More emotionally-arousing information increases amygdalar activity, and that activity correlates with retention. Amygdala neurons show various types of oscillation during emotional arousal, such as theta activity. These synchronized neuronal events could promote synaptic plasticity (which is involved in memory retention) by increasing interactions between neocortical storage sites and temporal lobe structures involved in declarative memory.^[32]

Rorschach test blot 03

Research using Rorschach test blot 03 finds that the number of unique responses to this random figure links to larger sized amygdalae. The researchers note, "Since previous reports have indicated that unique responses were observed at higher frequency in the artistic population than in the nonartistic normal population, this positive correlation suggests that amygdalar enlargement in the normal population might be related to creative mental activity."^[33]

Neuropsychological correlates of amygdala activity

Early research on primates provided explanations as to the functions of the amygdala, as well as a basis for further research. As early as 1888, rhesus monkeys with a lesioned temporal cortex (including the amygdala) were observed to have significant social and emotional deficits.^[34] Heinrich Klüver and Paul Bucy later expanded upon this same observation by showing that large lesions to the anterior temporal lobe produced noticeable changes, including overreaction to all objects, hypoemotionality, loss of fear, hypersexuality, and hyperorality, a condition in which inappropriate objects are placed in the mouth. Some monkeys also displayed an inability to recognize familiar objects and would approach animate and inanimate objects indiscriminately, exhibiting a loss of fear towards the experimenters. This behavioral disorder was later named Klüver-Bucy syndrome accordingly,^[35] and later research proved it was specifically due to amygdala lesions. Monkey mothers who had amygdala damage showed a reduction in maternal behaviors towards their infants, often physically abusing or neglecting them.^[36] In 1981, researchers found that selective radio frequency lesions of the whole amygdala caused Klüver-Bucy Syndrome.^[37]

With advances in neuroimaging technology such as MRI, neuroscientists have made significant findings concerning the amygdala in the human brain. A variety of data shows the amygdala has a substantial role in mental states, and is related to many psychological disorders. Some studies have shown children with anxiety disorders tend to have a smaller left amygdala. In the majority of the cases, there was an association between an increase in the size of the left amygdala with the use of SSRI's (antidepressant medication) or psychotherapy. The left amygdala has been linked to social anxiety, obsessive and compulsive disorders, and post traumatic stress, as well as more broadly to separation and general anxiety.^[38] In a 2003 study, subjects with borderline personality disorder showed significantly greater left amygdala activity than normal control subjects. Some borderline patients even had difficulties classifying neutral faces or saw them as threatening.^[39] Individuals with psychopathy show reduced autonomic responses, relative to comparison individuals, to instructed fear cues.^[40] In 2006, researchers observed hyperactivity in the amygdala when patients were shown threatening faces or confronted with frightening situations. Patients with more severe social phobia showed a correlation with increased response in the amygdala.^[41] Similarly, depressed patients showed exaggerated left amygdala activity when interpreting emotions for all faces, and especially for fearful faces. Interestingly, this hyperactivity was normalized when patients were administered antidepressant medication.^[42] By contrast, the amygdala has been observed to respond differently in people with bipolar disorder. A 2003 study found that adult and adolescent bipolar patients tended to have considerably smaller amygdala volumes and somewhat smaller hippocampal volumes.^[43] Many studies have focused on the connections between the amygdala and autism.^[44]

Studies in 2004 and 2006 showed that normal subjects exposed to images of frightened faces or faces of people from another race will show increased activity of the amygdala, even if that exposure is subliminal.^[45]^[46] However, the amygdala is not necessary for the processing of fear-related stimuli, since persons in whom it is bilaterally damaged show rapid reactions to fearful faces, even in the absence of a functional amygdala.^[47]

Recent research suggests that parasites, in particular toxoplasma, form cysts in the brain of rats, often taking up residence in the amygdala. This may provide clues as to how specific parasites may contribute to the development of disorders, including paranoia.^[48]

Future studies have been proposed to address the role of the amygdala in positive emotions, and the ways in which the amygdala networks with other brain regions.^[49]

Sexual orientation

Recent studies have suggested possible correlations between brain structure, including differences in hemispheric ratios and connection patterns in the amygdala, and sexual orientation. Homosexual men tend to exhibit more female-like patterns in the amygdala than heterosexual males do, just as homosexual females tend to show more male-like patterns in the amygdala than heterosexual women do. It was observed that amygdala connections were more widespread from the left amygdala in homosexual males, as is also found in heterosexual females. Amygdala connections were more widespread from the right amygdala in homosexual females, as in heterosexual males.^[50] ^[50]^[51]

Social interaction

Amygdala volume correlates positively with both the size (the number of contacts a person has) and the complexity (the number of different groups to which a person belongs) of social networks.^[52]^[53] Individuals with larger amygdalae had larger and more complex social networks. They were also better able to make accurate social judgments about other persons' faces.^[54] It is hypothesized that larger amygdalae allow for greater emotional intelligence, enabling greater societal integration and cooperation with others.^[55]

The amygdala processes reactions to violations concerning personal space. These reactions are absent in persons in whom the amygdala is damaged bilaterally.^[56] Furthermore, the amygdala is found to be activated in fMRI when people observe that others are physically close to them, such as when a person being scanned knows that an experimenter is standing immediately next to the scanner, versus standing at a distance.^[56]

Aggression

Animal studies have shown that stimulating the amygdala appears to increase both sexual and aggressive behavior. Likewise, studies using brain lesions have shown that harm to the amygdala may produce the opposite effect. Thus, it appears that this part of the brain may play a role in the display and modulation of aggression.^[57]

Fear

There are cases of human patients with focal bilateral amygdala lesions, due to the rare genetic condition Urbach-Wiethe disease.^[58]^[59] Such patients fail to exhibit fear-related behaviors, leading one to be dubbed the "woman with no fear". This finding reinforces the conclusion that the amygdala "plays a pivotal role in triggering a state of fear".^[60]

Alcoholism and binge drinking

The amygdala appears to play a role in binge drinking, being damaged by repeated episodes of intoxication and withdrawal.^[61] Alcoholism is associated with dampened activation in brain networks responsible for emotional processing, including the amygdala.^[62] Protein kinase C-epsilon in the amygdala is important for regulating behavioral responses to morphine, ethanol, and controlling anxiety-like behavior. The protein is involved in controlling the function of other proteins and plays a role in development of the ability to consume a large amount of ethanol.^[63]^[64]

Anxiety

There may also be a link between the amygdala and anxiety.^[65] In particular, there is a higher prevalence of females that are affected by anxiety disorders. In an experiment, degu pups were removed from their mother but allowed to hear her call. In response, the males produced increased serotonin receptors in the amygdala but females lost them. This led to the males being less affected by the stressful situation.

Posttraumatic Stress Disorder

There seems to be a connection with the amygdala and how the brain processes posttraumatic stress disorder. Multiple studies have found that the amygdala may be responsible for the emotional reactions of PTSD patients. One study in specific found that when PTSD patients are shown pictures of faces with fearful expressions, their amygdalas tended to have a higher activation than someone without PTSD.^[66]

References

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^ Feinstein, Justin S.; Adolphs, Ralph; Damasio, Antonio; Tranel, Daniel (2011). "The Human Amygdala and the Induction and Experience of Fear". Current Biology 21 (1): 34–8. doi:10.1016/j.cub.2010.11.042. PMC 3030206. PMID 21167712.
^ Staut, C. C. V.; Naidich, T. P. (1998). "Urbach-Wiethe Disease(Lipoid Proteinosis)". Pediatric Neurosurgery 28 (4): 212–214. doi:10.1159/000028653. PMID 9732251. edit
^ http://bps-research-digest.blogspot.com/2013/02/extreme-fear-experienced-without.html^{[full citation needed]}
^ Stephens, D. N; Duka, T. (2008). "Cognitive and emotional consequences of binge drinking: Role of amygdala and prefrontal cortex". Philosophical Transactions of the Royal Society B 363 (1507): 3169–79. doi:10.1098/rstb.2008.0097. PMC 2607328. PMID 18640918.
^ Marinkovic, Ksenija; Oscar-Berman, Marlene; Urban, Trinity; o’Reilly, Cara E.; Howard, Julie A.; Sawyer, Kayle; Harris, Gordon J. (2009). "Alcoholism and Dampened Temporal Limbic Activation to Emotional Faces". Alcoholism: Clinical and Experimental Research 33 (11): 1880–92. doi:10.1111/j.1530-0277.2009.01026.x. PMC 3543694. PMID 19673745.
^ Newton, P; Ron, D (2007). "Protein kinase C and alcohol addiction". Pharmacological Research 55 (6): 570–7. doi:10.1016/j.phrs.2007.04.008. PMID 17566760.
^ Lesscher, H. M. B.; Wallace, M. J.; Zeng, L.; Wang, V.; Deitchman, J. K.; McMahon, T.; Messing, R. O.; Newton, P. M. (2009). "Amygdala protein kinase C epsilon controls alcohol consumption". Genes, Brain and Behavior 8 (5): 493–9. doi:10.1111/j.1601-183X.2009.00485.x. PMC 2714877. PMID 19243450.
^ Ziabreva, Irina; Poeggel, Gerd; Schnabel, Reinhild; Braun, Katharina (2003). "Separation-induced receptor changes in the hippocampus and amygdala of Octodon degus: Influence of maternal vocalizations". The Journal of Neuroscience 23 (12): 5329–36. PMID 12832558.
^ Carlson, Neil R. (1/12/2012). Physiology of Behavior. Pearson. p. 608. ISBN 978-0205239399. Check date values in: |date= (help)

External links

Look up amygdala in Wiktionary, the free dictionary.

Media related to amygdala at Wikimedia Commons
Stained brain slice images which include the "amygdala " at the BrainMaps project
Scholarpedia article by Dr. Joseph LeDoux

UpToDate Contents

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1. 小児の身体組成測定 measurement of body composition in children
2. 成人における異物摂取および食物陥頓 ingested foreign bodies and food impactions in adults
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English Journal

Mechanisms of insulin resistance in the amygdala: Influences on food intake.

Areias MF1, Prada PO2.
Behavioural brain research.Behav Brain Res.2015 Apr 1;282C:209-217. doi: 10.1016/j.bbr.2015.01.003. Epub 2015 Jan 16.
Obesity is increasing worldwide and is triggered, at least in part, by enhanced caloric intake. Food intake is regulated by a complex mechanism involving the hypothalamus and hindbrain circuitries. However, evidences have showing that reward systems are also important in regulating feeding behavior.
PMID 25601576

Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: Potential relevance of limbic GAD.

Ortiz JB1, Taylor SB2, Hoffman AN3, Campbell AN4, Lucas LR5, Conrad CD6.
Behavioural brain research.Behav Brain Res.2015 Apr 1;282:176-84. doi: 10.1016/j.bbr.2014.12.051. Epub 2015 Jan 13.
Chronic restraint stress alters hippocampal-dependent spatial learning and memory in a sex-dependent manner, impairing spatial performance in male rats and leaving intact or facilitating performance in female rats. Moreover, these stress-induced spatial memory deficits improve following post-stress
PMID 25591480

Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors.

Sagalajev B1, Bourbia N1, Beloushko E1, Wei H1, Pertovaara A2.
Behavioural brain research.Behav Brain Res.2015 Apr 1;282:14-24. doi: 10.1016/j.bbr.2014.12.052. Epub 2014 Dec 31.
Amygdala is involved in processing of primary emotions and particularly its central nucleus (CeA) also in pain control. Here we studied mechanisms mediating the descending control of mechanical hypersensitivity by the CeA in rats with a peripheral neuropathy in the left hind limb. For drug administr
PMID 25557801

Japanese Journal

痛みの認知と情動

日本顎咬合学会誌咬み合わせの科学 35(1-2), 88-93, 2015
NAID 130005158116

Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment.

Neuroscience 272, 34-57, 2014-07-11
NAID 120005439547

高齢統合失調症者の表情認知に関する神経心理学的基礎研究

花園大学社会福祉学部研究紀要 19, 37-44, 2011-03
NAID 110008154679

Related Pictures

★リンクテーブル★

リンク元	「扁桃体」
関連記事	「amygdaloid」「body」

「扁桃体」

Brain: Amygdala
	Location of the amygdalae in the human brain
	Subdivision of the amygdala
Latin	corpus amygdaloideum
Gray's	p.835
NeuroNames	hier-219
MeSH	Amygdala
NeuroLex ID	birnlex_1241
TA	A14.1.09.402
FMA	FMA:61841

　　[★]

英: amygdaloid body (N,B,KL), amygdaloid nuclear complex (KH), amygdala (KA)
同: 扁桃核 amygdaloid nucleus

図：KL.744(模式図)

機能

本能や情動に基づく行動の中枢。

解剖

側頭葉の下方かつ先端に鈎があり、その深部にある

線維連絡

視床、視床下部、前頭葉、側頭葉

「amygdaloid」

　　[★]

扁桃体の

関: amygdala、amygdaloid body

「body」

　　[★]

n.

体、本体、身体、ボディー

[dictionary.com-1] ygdala – Definitions from Dictionary.com

[2] University of Idaho College of Science (2004). "amygdala". Archived from the original on 31 March 2007. Retrieved 15 March 2007.

[rd-3] Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah N, Habel U, Schneider F, Zilles K (2005). "Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps". Anat Embryol (Berl) 210 (5–6): 343–52. doi:10.1007/s00429-005-0025-5. PMID 16208455.

[4] Bzdok D, Laird A, Zilles K, Fox PT, Eickhoff S.: An investigation of the structural, connectional and functional sub-specialization in the human amygdala. Human Brain Mapping, 2012.

[emotion-5] Ben Best (2004). "The Amygdala and the Emotions". Archived from the original on 9 March 2007. Retrieved 15 March 2007.

[Solano-Castiella-6] Solano-Castiella E, Anwander A, Lohmann G, Weiss M, Docherty C, Geyer S, Reimer E, Friederici AD, Turner R (2010). "Diffusion tensor imaging segments the human amygdala in vivo". Neuroimage 49 (4): 2958–65. doi:10.1016/j.neuroimage.2009.11.027. PMID 19931398.

[7] See Amygdala in the BrainInfo database

[8] Larry W. Swanson and Gorica D. Petrovich (August 1998). "What is the amygdala?". Trends in Neurosciences 21 (8): 323–331. doi:10.1016/S0166-2236(98)01265-X.

[amygdala_hemispheric_specialization1-9] Lanteaume, L. et al. (Jun 2007). "Emotion induction after direct intracerebral stimulations of human amygdala". Cerebral Cortex 17 (6): 1307–13. doi:10.1093/cercor/bhl041. PMID 16880223.

[amygdala_hemispheric_specialization2-10] Murray, Elizabeth A., et al. (2009). "Amygdala function in positive reinforcement". The Human Amygdala. Guilford Press.

[11] Caviness, V. S.; Kennedy, D. N.; Richelme, C.; Rademacher, J.; Filipek, P. A. (1996). "The Human Brain Age 7–11 Years: A Volumetric Analysis Based on Magnetic Resonance Images". Cerebral Cortex 6 (5): 726–36. doi:10.1093/cercor/6.5.726. PMID 8921207.

[12] Goldstein, J. M.; Seidman, LJ; Horton, NJ; Makris, N; Kennedy, DN; Caviness Jr, VS; Faraone, SV; Tsuang, MT (2001). "Normal Sexual Dimorphism of the Adult Human Brain Assessed by in Vivo Magnetic Resonance Imaging". Cerebral Cortex 11 (6): 490–7. doi:10.1093/cercor/11.6.490. PMID 11375910.

[13] Hines, Melissa; Allen, Laura S.; Gorski, Roger A. (1992). "Sex differences in subregions of the medial nucleus of the amygdala and the bed nucleus of the stria terminalis of the rat". Brain Research 579 (2): 321–6. doi:10.1016/0006-8993(92)90068-K. PMID 1352729.

[14] Cahill, L; Haier, RJ; White, NS; Fallon, J; Kilpatrick, L; Lawrence, C; Potkin, SG; Alkire, MT (2001). "Sex-Related Difference in Amygdala Activity during Emotionally Influenced Memory Storage". Neurobiology of Learning and Memory 75 (1): 1–9. doi:10.1006/nlme.2000.3999. PMID 11124043.

[15] Hamann, Stephan (2005). "Sex Differences in the Responses of the Human Amygdala". Neuroscience update 11 (4): 288. doi:10.1177/1073858404271981. PMID 16061516. |accessdate= requires |url= (help)

[16] Lanteaume, L.; Khalfa, S.; Régis, J.; Marquis, P.; Chauvel, P.; Bartolomei, F. (2006). "Emotion Induction After Direct Intracerebral Stimulations of Human Amygdala". Cerebral Cortex 17 (6): 1307–13. doi:10.1093/cercor/bhl041. PMID 16880223.

[17] Carlson, Neil (1/12/2012). Physiology of behavior. Pearson. p. 336. ISBN 978-0205239399. Check date values in: |date= (help)

[18] Groshek, Frank; Kerfoot, Erin; McKenna, Vanessa; Polackwich, Alan S.; Gallagher, Michela; Holland, Peter C. (2005). "Amygdala Central Nucleus Function is Necessary for Learning, but Not Expression, of Conditioned Auditory Orienting". Behavioral Neuroscience 119 (1): 202–12. doi:10.1037/0735-7044.119.1.202. PMC 1255918. PMID 15727525.

[19] Carlson, Neil R. (1/12/2012). Physiology of Behavior. Pearson. p. 364. ISBN 978-0205239399. Check date values in: |date= (help)

[20] Carlson, Neil R. (1/12/2012). Physiology of Behavior. Pearson. p. 453. ISBN 978-0205239399. Check date values in: |date= (help)

[21] Paton, Joseph J.; Belova, Marina A.; Morrison, Sara E.; Salzman, C. Daniel (2006). "The primate amygdala represents the positive and negative value of visual stimuli during learning". Nature 439 (7078): 865–70. doi:10.1038/nature04490. PMC 2396495. PMID 16482160.

[Dissociable_roles_of_the_central_and_basolateral_amygdala_in_appetitive_emotional_learning-22] Parkinson, John A.; Robbins, Trevor W.; Everitt, Barry J. (2000). "Dissociable roles of the central and basolateral amygdala in appetitive emotional learning". European Journal of Neuroscience 12 (1): 405–13. doi:10.1046/j.1460-9568.2000.00960.x. PMID 10651899.

[23] See recent TINS article by Balleine and Killcross (2006)^{[verification needed]}

[24] Maren (Dec 1999). "Long-term potentiation in the amygdala: a mechanism for emotional learning and memory". Trends Neurosci 22 (12): 561–7. doi:10.1016/S0166-2236(99)01465-4. PMID 10542437.

[25] Killcross S, Robbins T, Everitt B (1997). "Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala". Nature 388 (6640): 377–80. doi:10.1038/41097. PMID 9237754.

[26] Blair, H. T. (2001). "Synaptic Plasticity in the Lateral Amygdala: A Cellular Hypothesis of Fear Conditioning". Learning & Memory 8 (5): 229. doi:10.1101/lm.30901.

[27] "Researchers Prove A Single Memory Is Processed In Three Separate Parts Of The Brain" http://www.sciencedaily.com/releases/2006/02/060202182107.htm

[28] Ferry B, Roozendaal B, McGaugh J (1999). "Role of norepinephrine in mediating stress hormone regulation of long-term memory storage: a critical involvement of the amygdala". Biol Psychiatry 46 (9): 1140–52. doi:10.1016/S0006-3223(99)00157-2. PMID 10560021.

[29] "Cultivating compassion: Neuroscientific and behavioral approaches" a talk given by Richard J. Davidson found online at http://ccare.stanford.edu/node/25

[30] Lutz, Antoine; Brefczynski-Lewis, Julie; Johnstone, Tom; Davidson, Richard J. (2008). "Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise". In Baune, Bernhard. PLoS ONE 3 (3): e1897. doi:10.1371/journal.pone.0001897. PMC 2267490. PMID 18365029.

[31] Hutcherson, Cendri A.; Seppala, Emma M.; Gross, James J. (2008). "Loving-kindness meditation increases social connectedness". Emotion 8 (5): 720–4. doi:10.1037/a0013237. PMID 18837623.

[32] Paré D., Collins D.R., Pelletier J.G. (2002). "Amygdala oscillations and the consolidation of emotional memories". Trends in Cognitive Sciences 6 (7): 306–314. doi:10.1016/S1364-6613(02)01924-1. PMID 12110364.

[33] Asari T, Konishi S, Jimura K, Chikazoe J, Nakamura N, Miyashita Y (2010). "Amygdalar enlargement associated with unique perception". Cortex 46 (1): 94–99. doi:10.1016/j.cortex.2008.08.001. PMID 18922517.

[34] Brown, S. & Shafer, E. (1888). "An investigation into the functions of the occipital and temporal lobes of the monkey's brain". Philosophical Transactions of the Royal Society B 179: 303–327. doi:10.1098/rstb.1888.0011.

[35] Kluver, H. & Bucy, P. (1939). "Preliminary analysis of function of the temporal lobe in monkeys". Archives of Neurology 42 (6): 979–1000. doi:10.1001/archneurpsyc.1939.02270240017001.

[36] Bucher, K., Myersn, R., Southwick, C. (1970). "Anterior temporal cortex and maternal behaviour in monkey". Neurology 20 (4): 415. PMID 4998075.

[37] Aggleton, JP. & Passingham, RE. (1981). "Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta)". Journal of Comparative and Physiological Psychology 95 (6): 961–977. doi:10.1037/h0077848. PMID 7320283.

[38] ttp://pn.psychiatryonline.org/content/40/9/37.full^{[dead link]}^{[full citation needed]}

[39] Donegan et al.; Sanislow, CA; Blumberg, HP; Fulbright, RK; Lacadie, C; Skudlarski, P; Gore, JC; Olson, IR; McGlashan, TH (2003). "Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation". Biological Psychiatry 54 (11): 1284–1293. doi:10.1016/S0006-3223(03)00636-X. PMID 14643096.

[40] R. J. R. Blair (23 April 2008). "The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy". Philosophical Transactions of the Royal Society 363 (1503): 2557–2565. doi:10.1098/rstb.2008.0027. PMC 2606709. PMID 18434283.

[41] Studying Brain Activity Could Aid Diagnosis Of Social Phobia. Monash University. 19 January 2006.

[42] Sheline et al.; Barch, DM; Donnelly, JM; Ollinger, JM; Snyder, AZ; Mintun, MA (2001). "Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study". Biological Psychiatry 50 (9): 651–658. doi:10.1016/S0006-3223(01)01263-X. PMID 11704071.

[43] Blumberg et al.; Kaufman, J; Martin, A; Whiteman, R; Zhang, JH; Gore, JC; Charney, DS; Krystal, JH; Peterson, BS (2003). "Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder". Arch Gen Psychiatry 60 (12): 1201–8. doi:10.1001/archpsyc.60.12.1201. PMID 14662552.

[44] Schultz RT (2005). "Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area". Int J Dev Neurosci 23 (2–3): 125–41. doi:10.1016/j.ijdevneu.2004.12.012. PMID 15749240.

[45] Williams, Leanne M.; Belinda J. Liddell; Andrew H. Kemp; Richard A. Bryant; Russell A. Meares; Anthony S. Peduto; Evian Gordon (2006). "Amygdala-prefrontal dissociation of subliminal and supraliminal fear". Human Brain Mapping 27 (8): 652–661. doi:10.1002/hbm.20208. PMID 16281289.

[46] Brain Activity Reflects Complexity Of Responses To Other-race Faces, Science Daily, 14 December 2004

[47] Tsuchiya N, Moradi F, Felsen C, Yamazaki M, Adolphs R (2009). "Intact rapid detection of fearful faces in the absence of the amygdala". Nature Neuroscience 12 (10): 1224–12225. doi:10.1038/nn.2380. PMC 2756300. PMID 19718036.

[48] Vyas et al.; Kim, SK; Giacomini, N; Boothroyd, JC; Sapolsky, RM (2007). "Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors". Proceedings of the National Academy of Sciences of the United States of America 104 (15): 6442–7. doi:10.1073/pnas.0608310104. PMC 1851063. PMID 17404235.

[49] Gazzaniga, M.S., Ivry, R.B., & Mangun, G.R. (2009). Cognitive neuroscience: the biology of the mind. NY: W.W.Norton&Company.^{[page needed]}

[pnas-50] Swaab, D. F. (2008). "Sexual orientation and its basis in brain structure and function". Proceedings of the National Academy of Sciences of the United States of America 105 (30): 10273–4. doi:10.1073/pnas.0805542105. PMC 2492513. PMID 18653758.

[51] Swaab, Dick F. (2007). "Sexual differentiation of the brain and behavior". Best Practice & Research Clinical Endocrinology & Metabolism 21 (3): 431–44. doi:10.1016/j.beem.2007.04.003. PMID 17875490.

[52] Bickart, Kevin C; Wright, Christopher I; Dautoff, Rebecca J; Dickerson, Bradford C; Barrett, Lisa Feldman (2010). "Amygdala volume and social network size in humans". Nature Neuroscience 14 (2): 163–4. doi:10.1038/nn.2724. PMC 3079404. PMID 21186358.

[53] Szalavitz, Maia (28 December 2010). "How to Win Friends: Have a Big Amygdala?". Time. Retrieved 30 December 2010.

[54] Bzdok, D.; Langner, R.; Caspers, S.; Kurth, F.; Habel, U.; Zilles, K.; Laird, A.; Eickhoff, Simon B. (2010). "ALE meta-analysis on facial judgments of trustworthiness and attractiveness". Brain Structure and Function 215 (3–4): 209–23. doi:10.1007/s00429-010-0287-4. PMID 20978908.

[55] Buchanan, T.W., Tranel, D. & Adolphs, R. in The Human Amygdala (eds. Whalen, P.J. & Phelps, E.A.) 289–318 (Guilford, New York, 2009).

[Kennedy-56] Kennedy DP, Gläscher J, Tyszka JM, Adolphs R (2009). "Personal space regulation by the human amygdala". Nature Neuroscience 12 (10): 1226–1227. doi:10.1038/nn.2381. PMC 2753689. PMID 19718035.

[57] T.L. Brink. (2008) Psychology: A Student Friendly Approach. "Unit 4: The Nervous System." pp 61 [1]

[58] Feinstein, Justin S.; Adolphs, Ralph; Damasio, Antonio; Tranel, Daniel (2011). "The Human Amygdala and the Induction and Experience of Fear". Current Biology 21 (1): 34–8. doi:10.1016/j.cub.2010.11.042. PMC 3030206. PMID 21167712.

[Staut-1998-59] Staut, C. C. V.; Naidich, T. P. (1998). "Urbach-Wiethe Disease(Lipoid Proteinosis)". Pediatric Neurosurgery 28 (4): 212–214. doi:10.1159/000028653. PMID 9732251. edit

[60] ttp://bps-research-digest.blogspot.com/2013/02/extreme-fear-experienced-without.html^{[full citation needed]}

[61] Stephens, D. N; Duka, T. (2008). "Cognitive and emotional consequences of binge drinking: Role of amygdala and prefrontal cortex". Philosophical Transactions of the Royal Society B 363 (1507): 3169–79. doi:10.1098/rstb.2008.0097. PMC 2607328. PMID 18640918.

[62] Marinkovic, Ksenija; Oscar-Berman, Marlene; Urban, Trinity; o’Reilly, Cara E.; Howard, Julie A.; Sawyer, Kayle; Harris, Gordon J. (2009). "Alcoholism and Dampened Temporal Limbic Activation to Emotional Faces". Alcoholism: Clinical and Experimental Research 33 (11): 1880–92. doi:10.1111/j.1530-0277.2009.01026.x. PMC 3543694. PMID 19673745.

[63] Newton, P; Ron, D (2007). "Protein kinase C and alcohol addiction". Pharmacological Research 55 (6): 570–7. doi:10.1016/j.phrs.2007.04.008. PMID 17566760.

[64] Lesscher, H. M. B.; Wallace, M. J.; Zeng, L.; Wang, V.; Deitchman, J. K.; McMahon, T.; Messing, R. O.; Newton, P. M. (2009). "Amygdala protein kinase C epsilon controls alcohol consumption". Genes, Brain and Behavior 8 (5): 493–9. doi:10.1111/j.1601-183X.2009.00485.x. PMC 2714877. PMID 19243450.

[65] Ziabreva, Irina; Poeggel, Gerd; Schnabel, Reinhild; Braun, Katharina (2003). "Separation-induced receptor changes in the hippocampus and amygdala of Octodon degus: Influence of maternal vocalizations". The Journal of Neuroscience 23 (12): 5329–36. PMID 12832558.

[66] Carlson, Neil R. (1/12/2012). Physiology of Behavior. Pearson. p. 608. ISBN 978-0205239399. Check date values in: |date= (help)

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amygdaloid body