アミノメチル安息香酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/03/29 10:32:15」(JST)
[Wiki en表示]
Aminomethylbenzoic acid
|
Systematic (IUPAC) name |
4-(aminomethyl)benzoic acid |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
℞-only (US) |
Identifiers |
CAS number |
56-91-7 |
ATC code |
B02AA03 |
PubChem |
CID 65526 |
ChemSpider |
58971 Y |
KEGG |
D07568 Y |
ChEMBL |
CHEMBL328875 Y |
Chemical data |
Formula |
C8H9NO2 |
Mol. mass |
151.163 g/mol |
|
InChI
-
InChI=1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11) Y
Key:QCTBMLYLENLHLA-UHFFFAOYSA-N Y
|
Physical data |
Density |
1.239 g/cm³ |
Melt. point |
300 °C (572 °F) |
Boiling point |
310.7 °C (591 °F) |
Y (what is this?) (verify)
|
Aminomethylbenzoic acid (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic.
See also
Antihemorrhagics (B02)
|
|
Hemostatics
(coagulation) |
Systemic
|
Vitamin K
|
- Phytomenadione (K1)
- Menadione (K3)
|
|
Coagulation factors
|
- intrinsic: IX/Nonacog alfa
- VIII
- extrinsic: VII/Eptacog alfa
- common: X
- II/Thrombin
- I/Fibrinogen
|
|
Other systemic
|
- Etamsylate
- Carbazochrome
- Batroxobin
- thrombopoietin receptor agonist (Romiplostim
- Eltrombopag)
|
|
|
Local
|
- Absorbable gelatin sponge
- Oxidized cellulose
- Tetragalacturonic acid hydroxymethylester
- Thrombin
- Collagen
- Calcium alginate
- Epinephrine/Adrenalone
|
|
|
Antifibrinolytics |
- amino acids (Aminocaproic acid
- Tranexamic acid
- Aminomethylbenzoic acid)
serpins (Aprotinin
- Alfa1 antitrypsin
- C1-inhibitor
- Camostat)
|
|
|
cell/phys (coag, heme, immu, gran), csfs
|
rbmg/mogr/tumr/hist, sysi/epon, btst
|
drug (B1/2/3+5+6), btst, trns
|
|
|
|
UpToDate Contents
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English Journal
- Design and Synthesis of ATP-Based Nucleotide Analogues and Profiling of Nucleotide-Binding Proteins.
- Wolters JC, Roelfes G, Poolman B.SourceDepartment of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre & Zernike Institute for Advanced Materials.
- Bioconjugate chemistry.Bioconjug Chem.2011 Jul 20;22(7):1345-53. Epub 2011 Jun 30.
- Two nucleotide-based probes were designed and synthesized in order to enrich samples for specific classes of proteins by affinity-based protein profiling. We focused on the profiling of adenine nucleotide-binding proteins. Two properties were considered in the design of the probes: the bait needs to
- PMID 21692528
- [The design of muti-target antitumor drugs affecting on FTase and Raf-1 kinase].
- Zhao J, Zhu YJ, Zeng L, Wang Q, Jiang FC.SourceSchool of Pharmacy, Tong]i Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Yao xue xue bao = Acta pharmaceutica Sinica.Yao Xue Xue Bao.2011 Feb;46(2):170-8.
- Ras/Raf/MEK/ERK singal transduction plays an important role in cell proliferation, differentiation, apoptosis, metastasis and metabolism. This investigation focused on this signal pathway and chose farnesyl transferase (FTase) as the main target and Raf-1 kinase as the second target. A lot of compou
- PMID 21542288
Japanese Journal
- A Facile Synthesis of Aminocarboxylic Acid Derivatives, New Anti-ulcer Agents
- 竹下 徹,近藤 史郎,成智 達之
- Chemical & pharmaceutical bulletin 33(11), 5059-5061, 1985-11-25
- … 3- [p-(trans-4-Aminomethylcyclohexylcarbonyl)phenyl] propionic acid hydrochloride (1a), a new anti-ulcer agent, was newly synthesized from trans- or mixed trans/cis-4-aminomethyl-cyclohexanecarboxylic acid and methyl 3-phenylpropionate (4) in three steps. … Friedel-Crafts reaction of the acid chloride 3 and 4 was performed without any particular protection of the amino group of 3. …
- NAID 110003625297
- Medicinal Chemical Studies on Antiplasmin Drugs. VI. Aza Analogs of 4-Aminomethylbenzoic Acid
- 磯田 純郎,山口 等,佐藤 嘉生,三木 藤作,平田 三四司
- Chemical & pharmaceutical bulletin 28(5), 1408-1414, 1980-05-25
- … Four aza analogs of 4-aminomethylbenzoic acid (1) were prepared as part of a search for new antiplasmin drugs. … 5-Aminomethylpyridine-2-carboxylic acid (5) was prepared by the hydrogenation of methyl 5-cyanopyridine-2-carboxylate (4), followed by alkaline hydrolysis. … Similarly, 6-aminomethylpyridine-3-carboxylic acid (7) was prepared from ethyl 6-cyanopyridine-3-carboxylate (6). …
- NAID 110003662505
Related Links
- InChI=1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11) Yes Y Key: QCTBMLYLENLHLA-UHFFFAOYSA-N Yes Y. Yes Y(what is this?) (verify). Aminomethylbenzoic acid (more precisely, 4-aminomethylbenzoic acid) is an antifibrinolytic. ...
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