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English Journal

Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.

Fratz EJ1, Clayton J1, Hunter GA1, Ducamp S2,3,4, Breydo L1, Uversky VN1, Deybach JC2,3,4, Gouya L2,3,4, Puy H2,3,4, Ferreira GC1,5.
Biochemistry.Biochemistry.2015 Sep 15;54(36):5617-31. doi: 10.1021/acs.biochem.5b00407. Epub 2015 Sep 2.
Regulation of 5-aminolevulinate synthase (ALAS) is at the origin of balanced heme production in mammals. Mutations in the C-terminal region of human erythroid-specific ALAS (hALAS2) are associated with X-linked protoporphyria (XLPP), a disease characterized by extreme photosensitivity, with elevated
PMID 26300302

[Peculiarities of the Structural-Functional State of the Cytochrome Part of Liver Mitochondrial Respiratory Chain under Conditions of Acetaminophen-induced Hepatitis against the Background of Alimentary Deprivation of Protein].

Voloshchuk ON, Kopylchuk GP.
Biofizika.Biofizika.2015 May-Jun;60(3):519-24.
Activity of the key enzyme of the cytochrome part of the respiratory chain--cytochrome oxidase, quantitative redistribution of mitochondrial cytochromes b, c1, c and aa3, activity of the key enzymes of cytochromes' heme metabolism--delta-aminolevulinate synthase and heme oxygenase under conditions o
PMID 26349215

Global analysis of posttranscriptional gene expression in response to sodium arsenite.

Qiu LQ1, Abey S, Harris S, Shah R, Gerrish KE, Blackshear PJ.
Environmental health perspectives.Environ Health Perspect.2015 Apr;123(4):324-30. doi: 10.1289/ehp.1408626. Epub 2014 Nov 21.
BACKGROUND: Inorganic arsenic species are potent environmental toxins and causes of numerous health problems. Most studies have assumed that arsenic-induced changes in mRNA levels result from effects on gene transcription.OBJECTIVES: We evaluated the prevalence of changes in mRNA stability in respon
PMID 25493608

田中享,西川誠司,渡辺圭太郎 [他],田中徹,佐々木健
生物工学会誌 : seibutsu-kogaku kaishi 88(9), 455-462, 2010-09-25
すでに得ている光合成細菌変異株R.spharoides CR-720株は,N-メチル-N'-ニトロ-N-ニトロソグアニジンによる変異を逐次行い取得した変異株であり,光照射せずに従来の変異株に対して5-アミノレブリン酸(ALA)を高蓄積する.本菌株は前駆体として50mMグルコース,60mMグリシン,ALA脱水酵素阻害剤として5mMレブリン酸および10gl^<-1>酵母エキス存在下,2l発 …
NAID 110007730754

新垣光雄
県立長崎シーボルト大学看護栄養学部紀要 1, 1-5, 2001-03
… ALA synthetase(ALAS) activities in each lobe of rat livers were measured to clarify a lobe-distribution of the enzyme. …
NAID 110000039563