アミノ馬尿酸

関: aminohippurate、p-aminohippuric acid

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/24 03:57:05」(JST)

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Aminohippuric acid or para-aminohippuric acid (PAH), a derivative of hippuric acid, is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow. It is an amide derivative of the amino acid glycine and para-aminobenzoic acid that is not naturally found in humans; it needs to be IV infused before use diagnostically.

Uses

Diagnostics

PAH is useful for the measurement of renal plasma flow.^[1]

The renal extraction ratio of PAH in a normal individual is approximately 0.92.^[2]

Pharmaceuticals

Aminohippuric acid is often used as the sodium salt sodium para-aminohippurate. During World War II, para-aminohippurate was given along with penicillin in order to prolong the time penicillin circulated in the blood. Because both penicillin and para-aminohippurate compete for the same transporter in the kidney, administering para-aminohippurate with penicillin decreased the clearance of penicillin from the body by the kidney, providing better antibacterial therapy. Transporters found in the kidney eliminate organic anions and cations from the blood by moving substances, in this case, drug metabolites, from blood into urine.

Other

In vultures, the NSAID diclofenac, which is extraordinarily toxic to vultures, interferes with the renal transport of uric acid via the PAH channel.^[3]

pKa = 3.83

References

^ Costanzo, Linda. Physiology, 4th Edition. Philadelphia: Lippincott Williams and Wilkins, 2007. Page 156-160.
^ Reubi, François C. (1953-04-29). "Glomerular filtration rate, renal blood flow and blood viscosity during and after diabetic coma". Circ. Res. 1 (5): 410–3. ISSN 0009-7330. PMID 13082682. Retrieved 2008-03-19.
^ Naidoo V, Swan GE (August 2008). "Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 149 (3): 269–74. doi:10.1016/j.cbpc.2008.07.014. PMID 18727958.

UpToDate Contents

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English Journal

The Use of p-Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation.

Nortje C1, van der Sluis R1, van Dijk AA1, Erasmus E2.
Journal of biochemical and molecular toxicology.J Biochem Mol Toxicol.2016 Mar;30(3):136-47. doi: 10.1002/jbt.21772. Epub 2015 Oct 20.
Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation capacity, and its regulatory factors has become increasingly important. Aspirin an
PMID 26484797

Molecular cloning and functional characterization of a glucose transporter (CsGLUT) in Clonorchis sinensis.

Ahn SK1, Cho PY1, Na BK2, Hong SJ3, Nam HW4, Sohn WM2, Ardelli BF5, Park YK1, Kim TS1, Cha SH6,7.
Parasitology research.Parasitol Res.2016 Jan;115(1):347-54. doi: 10.1007/s00436-015-4754-y. Epub 2015 Oct 9.
A complementary DNA (cDNA) encoding a glucose transporter of Clonorchis sinensis (CsGLUT) was isolated from the adult C. sinensis cDNA library. The open reading frame of CsGLUT cDNA consists of 1653 base pairs that encode a 550-amino acid residue protein. Hydropathy analysis suggested that CsGLUT po
PMID 26450594

A metabolomics strategy to explore urinary biomarkers and metabolic pathways for assessment of interaction between Danhong injection and low-dose aspirin during their synergistic treatment.

Li J1, Guo J2, Shang E1, Zhu Z1, Zhu KY1, Li S1, Zhao B3, Jia L3, Zhao J3, Tang Z4, Duan J5.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Jul 26. pii: S1570-0232(15)30112-4. doi: 10.1016/j.jchromb.2015.07.045. [Epub ahead of print]
The drug combination of Danhong injection (DHI) and low-dose aspirin (ASA) was frequently applied for the treatment of cardiovascular and cerebrovascular diseases. Due to the drug interactions, a lot of potential benefits and risks might exist side by side in the course of combination therapy. Howev
PMID 26265434

Japanese Journal

4-Aminohippuric Acid-functionalized Carbon Nanotubes for Stripping Voltammetric Determination of Copper(Ⅱ) Ions

Electrochemistry 84(3), 138-142, 2016
NAID 130005131410

新規ヒト有機酸排出トランスポーターhNPT4(SLC17A3)の輸送特性

痛風と核酸代謝 = Gout and nucleic acid
NAID 10029325947

Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(19), 1643-1646, 2010-06-01
NAID 10028037667

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リンク元	「aminohippurate」「アミノ馬尿酸」
拡張検索	「p-aminohippuric acid clearance」「p-aminohippuric acid」

「aminohippurate」

Aminohippurate
Clinical data
ATC code	V04CH30 (WHO);
Identifiers
	IUPAC name (4-Aminobenzamido)acetic acid;
Synonyms	PAH, PAHA, Aminohippurate, 4-Aminohippuric acid , N-(4-Aminobenzoyl)glycine, para-Aminohippurate
CAS Number	61-78-9 ;
PubChem CID	2148;
IUPHAR/BPS	4810;
DrugBank	DB00345 ;
ChemSpider	2063 ;
UNII	Y79XT83BJ9;
KEGG	D06890 ;
ChEBI	CHEBI:104011 ;
ChEMBL	CHEMBL463 ;
NIAID ChemDB	019143;
ECHA InfoCard	100.002.100
Chemical and physical data
Formula	C9H10N2O3
Molar mass	194.19 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C(c1ccc(N)cc1)NCC(=O)O ;
	InChI InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13) ; Key:HSMNQINEKMPTIC-UHFFFAOYSA-N ;
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　　[★]

アミノ馬尿酸

関: aminohippuric acid

aminohippuric acid

「アミノ馬尿酸」

　　[★]

英: aminohippurate、aminohippuric acid

「p-aminohippuric acid clearance」

　　[★] パラアミノ馬尿酸クリアランス

「p-aminohippuric acid」

　　[★] パラアミノ馬尿酸 PAH

[1] Costanzo, Linda. Physiology, 4th Edition. Philadelphia: Lippincott Williams and Wilkins, 2007. Page 156-160.

[pmid13082682-2] Reubi, François C. (1953-04-29). "Glomerular filtration rate, renal blood flow and blood viscosity during and after diabetic coma". Circ. Res. 1 (5): 410–3. ISSN 0009-7330. PMID 13082682. Retrieved 2008-03-19.

[pmid18727958-3] Naidoo V, Swan GE (August 2008). "Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 149 (3): 269–74. doi:10.1016/j.cbpc.2008.07.014. PMID 18727958.

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案内

aminohippuric acid