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  • Enantioseparation of racemic aminoglutethimide using asynchronous simulated moving bed chromatography.
  • Lin X1, Gong R1, Li J1, Li P2, Yu J3, Rodrigues AE4.
  • Journal of chromatography. A.J Chromatogr A.2016 Oct 7;1467:347-355. doi: 10.1016/j.chroma.2016.08.031. Epub 2016 Aug 12.
  • The separation of aminoglutethimide enantiomers by the continuous multicolumn chromatographic processes were investigated experimentally and theoretically, where the columns were packed with cellulose tris 3,5-dimethylphenyl-carbamate stationary phase (brand name Chiralcel OD) and mobile phase was a
  • PMID 27544751
  • TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being.
  • Da Pozzo E1, Giacomelli C2, Costa B3, Cavallini C4, Taliani S5, Barresi E6, Da Settimo F7, Martini C8.
  • International journal of molecular sciences.Int J Mol Sci.2016 Jun 29;17(7). pii: E1028. doi: 10.3390/ijms17071028.
  • The steroidogenic 18 kDa translocator protein (TSPO) is an emerging, attractive therapeutic tool for several pathological conditions of the nervous system. Here, 13 high affinity TSPO ligands belonging to our previously described N,N-dialkyl-2-phenylindol-3-ylglyoxylamide (PIGA) class were evaluated
  • PMID 27367681
  • TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.
  • Santoro A1, Mattace Raso G1, Taliani S2, Da Pozzo E2, Simorini F2, Costa B2, Martini C2, Laneri S1, Sacchi A1, Cosimelli B1, Calignano A1, Da Settimo F2, Meli R3.
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2016 Jun 10;88:124-31. doi: 10.1016/j.ejps.2016.04.006. Epub 2016 Apr 14.
  • Translocator protein 18kDa (TSPO) is predominantly located in the mitochondrial outer membrane, playing an important role in steroidogenesis, inflammation, cell survival and proliferation. Its expression in central nervous system, mainly in glial cells, has been found to be upregulated in neuropatho
  • PMID 27094781


  • Synthesis and Biological Evaluation of 16E-Arylidenosteroids as Cytotoxic and Anti-aromatase Agents
  • Bansal Ranju,Guleria Sheetal,Thota Sridhar [他],Hartmann Rolf Wolfgang,Zimmer Christina
  • Chemical and Pharmaceutical Bulletin 59(3), 327-331, 2011
  • … The imidazolyl substituted steroidal derivatives 5 and 7 exhibited strong inhibition of the aromatase enzyme with 16-[4-{3-(imidazol-1-yl)propoxy}-3-methoxybenzylidene]-5-androstene-3β,17β-diol (7) displaying 13 times more potency in comparison to aminoglutethimide. …
  • NAID 130000648940
  • Anti-inflammatory Effect of Theophylline in Rats and Its Involvement of the Glucocorticoid-Glucocorticoid Receptor System
  • Watanabe Shigekazu,Yamakami Jun,Tsuchiya Masao,Terajima Tomoko,Kizu Junko,Hori Seiji
  • Journal of Pharmacological Sciences 106(4), 566-570, 2008
  • … The inhibitory effect of theophylline on carrageenan-induced edema disappeared by pretreatment with aminoglutethimide, an inhibitor of glucocorticoid synthesis and with mefepristone, an antagonist of the glucocorticoid receptor. …
  • NAID 130000075798
  • Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons
  • Shirakawa Hisashi,Katsuki Hiroshi,Kume Toshiaki,Kaneko Shuji,Akaike Akinori,シワカワ ヒサシ,カツキ ヒロシ,クメ トシアキ,カネコ シュウジ,アカイケ アキノリ,白川 久志,香月 博志,久米 利明,金子 周司,赤池 昭紀
  • British Journal of Pharmacology 147(7), 729-736, 2006-04-01
  • Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. … Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of aminoglutethimide on cell death induced by overactivation of glutamate receptors in CNS neurons. …
  • NAID 120002468468


Mechanism [edit] Aminoglutethimide has two mechanisms of action: It blocks aromatase [2] in the generation of estrogens from androstenedione and testosterone. It blocks the conversion of cholesterol to pregnenolone by inhibiting ...
(ah-mee-no-gloo-TEH-tha-mide) Trade name: Cytadren ® uses generic names in all descriptions of drugs. Cytadren is the trade name for aminoglutethimide. In some cases, health care professionals may use ...


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