- アミノ安息香酸、(化合物)ミノ安息香酸エステル
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- 1. ペイロニー病：診断と内科的マネージメント peyronies disease diagnosis and medical management
English Journal
- NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10.
- Cordero MD1, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, Díaz-Parrado E, Pérez-Villegas EM, Bullón P, Battino M, Sánchez-Alcazar JA.Author information 11 Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla , Sevilla, Spain .AbstractAbstract Aims: Fibromyalgia (FM) is a prevalent chronic pain syndrome characterized by generalized hyperalgesia associated with a wide spectrum of symptoms such as fatigue and joint stiffness. Diagnosis of FM is difficult due to the lack of reliable diagnostic biomarkers, while treatment is largely inadequate. We have investigated the role of coenzyme Q10 (CoQ10) deficiency and mitochondrial dysfunction in inflammasome activation in blood cells from FM patients, and in vitro and in vivo CoQ10 deficiency models. Results: Mitochondrial dysfunction was accompanied by increased protein expression of interleukin (IL)-1β, NLRP3 (NOD-like receptor family, pyrin domain containing 3) and caspase-1 activation, and an increase of serum levels of proinflammatory cytokines (IL-1β and IL-18). CoQ10 deficiency induced by p-aminobenzoate treatment in blood mononuclear cells and mice showed NLRP3 inflammasome activation with marked algesia. A placebo-controlled trial of CoQ10 in FM patients has shown a reduced NLRP3 inflammasome activation and IL-1β and IL-18 serum levels. Innovation: These results show an important role for the NLRP3 inflammasome in the pathogenesis of FM, and the capacity of CoQ10 in the control of inflammasome. Conclusion: These findings provide new insights into the pathogenesis of FM and suggest that NLRP3 inflammasome inhibition represents a new therapeutic intervention for the disease. Antioxid. Redox Signal. 20, 1169-1180.
- Antioxidants & redox signaling.Antioxid Redox Signal.2014 Mar 10;20(8):1169-80. doi: 10.1089/ars.2013.5198. Epub 2013 Sep 19.
- Abstract Aims: Fibromyalgia (FM) is a prevalent chronic pain syndrome characterized by generalized hyperalgesia associated with a wide spectrum of symptoms such as fatigue and joint stiffness. Diagnosis of FM is difficult due to the lack of reliable diagnostic biomarkers, while treatment is largely
- PMID 23886272
- Effects of Para-Aminobenzoic Acid (PABA) Form and Administration Mode on PABA Recovery in 24-Hour Urine Collections.
- Sharma RS, Joy RC, Boushey CJ, Ferruzzi MG, Leonov AP, McCrory MA.AbstractPara-aminobenzoic acid (PABA) has long been used as an objective measure to assess completeness of 24-hour urine collections. However, pharmaceutical-grade PABA for human ingestion is not available in the United States. An alternative, the potassium salt of PABA, aminobenzoate potassium, can be obtained for clinical use, although it has not yet been validated in this role. Both PABA and aminobenzoate potassium can be directly ingested in their tablet or capsule forms or added to food before consumption. Our aim was to investigate the effect of form (PABA vs aminobenzoate potassium) and administration mode (directly ingested as a tablet/capsule vs added to food) on urinary PABA recovery levels. Twenty healthy participants underwent 3 test days separated by two 24-hour wash-out periods. Three test conditions, one on each test day, were investigated in randomized order: PABA tablet, aminobenzoate potassium capsule, and PABA or aminobenzoate potassium in food. Ingestion of each dose was supervised and participants performed the 24-hour urine collections while free-living. The 24-hour urine collections were analyzed for PABA recovery (%R) levels using a colorimetric assay. Recoveries 85% to 110% were deemed complete and those >110% were reanalyzed by high pressure liquid chromatography and mass spectrometry. Only complete collections (>85%R) were included in analyses. The recovery for the PABA tablet, aminobenzoate potassium capsule, and PABA/aminobenzoate potassium in food were similar at 98.8%R±2.0%R, 95.1%R±2.3%R, and 93.2%R±2.1%R, respectively, and did not differ significantly. These results suggest that aminobenzoate potassium may be used as an alternative to PABA for assessing the completeness of 24-hour urine collections and to track compliance with consuming provided diets in community-dwelling studies.
- Journal of the Academy of Nutrition and Dietetics.J Acad Nutr Diet.2014 Mar;114(3):457-63. doi: 10.1016/j.jand.2013.07.045. Epub 2013 Oct 30.
- Para-aminobenzoic acid (PABA) has long been used as an objective measure to assess completeness of 24-hour urine collections. However, pharmaceutical-grade PABA for human ingestion is not available in the United States. An alternative, the potassium salt of PABA, aminobenzoate potassium, can be obta
- PMID 24183994
- Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury.
- Prior AM1, Zhang M1, Blakeman N2, Datta P2, Pham H3, Chen Q3, Young LH3, Weis MT4, Hua DH5.Author information 1Department of Chemistry, 213 CBC Building, Kansas State University, Manhattan, KS 66506, United States.2Department of Biomedical Sciences, Vascular Drug Research Center, School of Pharmacy, Texas Tech University, Health Sciences Center, Amarillo, TX 79106, United States.3Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, United States.4Department of Biomedical Sciences, Vascular Drug Research Center, School of Pharmacy, Texas Tech University, Health Sciences Center, Amarillo, TX 79106, United States. Electronic address: Margaret.Weis@ttuhsc.edu.5Department of Chemistry, 213 CBC Building, Kansas State University, Manhattan, KS 66506, United States. Electronic address: duy@ksu.edu.AbstractVarious triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized and their inhibitions of long chain fatty acyl-CoA synthetase (ACSL) were examined. Two methods, a cell-based assay of ACSL activity and an in situ [(14)C]-palmitate incorporation into extractable lipids were used to study the inhibition. Using an in vivo leukocyte recruitment inhibition protocol, the translocation of one or more cell adhesion molecules from the cytoplasm to the plasma membrane on either the endothelium or leukocyte or both was inhibited by inhibitors 1, 9, and triacsin C. The results suggest that inhibition of ACSL may attenuate the vascular inflammatory component associated with ischemia reperfusion injury and lead to a decrease of infarct expansion.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Feb 15;24(4):1057-61. doi: 10.1016/j.bmcl.2014.01.016. Epub 2014 Jan 13.
- Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized and their inhibitions of long chain fatty acyl-CoA synthetase (ACSL) were
- PMID 24480468
Japanese Journal
- 症例 塩化ビニル手袋中2,2,4-トリメチル1,3ペンタネジオルジイソブチレートによるアレルギー性接触皮膚炎
- 足立 厚子,指宿 千恵子,福田 佳奈子 [他]
- Journal of environmental dermatology and cutaneous allergology = 日本皮膚アレルギー・接触皮膚炎学会雑誌 8(4), 271-280, 2014-10
- NAID 40020253678
- 2P-222 バクテリアにおける新規葉酸生合成関連遺伝子の同定(生合成,天然物化学,一般講演)
- 佐藤 康治,小林 大毅,大利 徹
- 日本生物工学会大会講演要旨集 66, 162, 2014-08-05
- NAID 110009906606
- New gene responsible for para-aminobenzoate biosynthesis(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Satoh Yasuharu,Kuratsu Masahiro,Kobayashi Daiki [他],Dairi Tohru
- Journal of bioscience and bioengineering 117(2), 178-183, 2014-02
- … para-Aminobenzoate (pABA), a building block of folate, is usually derived from chorismate in the shikimate pathway by reactions of amino-deoxychorismate synthase (PabA and -B) and 4-amino-4-deoxychorismate lyase (PabC). …
- NAID 110009804069
Related Links
- [Ethyl 4-Aminobenzoate] [94-09-7] | 価格や在庫、物性値などの詳細情報ページです 。
- Visit ChemicalBook To find more METHYL 3-AMINOBENZOATE(4518-10-9) information like chemical properties,Structure,melting point,boiling point,density, molecular formula,molecular weight, physical properties,toxicity information, customs ...
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| リンク元 | 「aminobenzoic acid」「アミノ安息香酸」「アミノ安息香酸エステル」 |
| 拡張検索 | 「ethyl piperidinoacetylaminobenzoate」「ethylaminobenzoate」 |
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