関: system L transporter

WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
the 12th letter of the Roman alphabet (同)l
pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
the radical -NH2 (同)amino_group

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
lira(イタリアの貨幣単位リラ)

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1. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
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3. 先天性代謝異常：分類 inborn errors of metabolism classification
4. 肝性脳症：病因 hepatic encephalopathy pathogenesis
5. 胎盤の発達および生理学 placental development and physiology

English Journal

Antitumor activity of an anti-CD98 antibody.

Hayes GM1, Chinn L1, Cantor JM2, Cairns B1, Levashova Z1, Tran H1, Velilla T1, Duey D1, Lippincott J1, Zachwieja J1, Ginsberg MH2, H van der Horst E1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Aug 1;137(3):710-20. doi: 10.1002/ijc.29415. Epub 2015 Jan 14.
CD98 is expressed on several tissue types and specifically upregulated on fast-cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell lung carcinoma) as well as hematological malignancies (e.g., acute myeloid leukemia) overexpress CD98. We have identified a CD98-specific mouse
PMID 25556716

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.

Kolev M1, Dimeloe S2, Le Friec G1, Navarini A3, Arbore G1, Povoleri GA4, Fischer M2, Belle R2, Loeliger J2, Develioglu L2, Bantug GR2, Watson J5, Couzi L6, Afzali B7, Lavender P5, Hess C8, Kemper C9.
Immunity.Immunity.2015 Jun 16;42(6):1033-47. doi: 10.1016/j.immuni.2015.05.024.
Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracellular
PMID 26084023

Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors.

Wu W1,2, Dong Y2,3, Gao J2, Gong M2, Zhang X4, Kong W2, Li Y2, Zeng Y2, Si D2, Wei Z2, Ci X2, Jiang L5, Li W2, Li Q2, Yi X2, Liu C1,2,4.
Cancer science.Cancer Sci.2015 Jun;106(6):747-56. doi: 10.1111/cas.12672. Epub 2015 May 26.
L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral amino acids. The aspa
PMID 25867020

Japanese Journal

Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood–Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina

Sakurai Tatsuhiko,Akanuma Shin-ichi,Usui Takuya [他],Kubo Yoshiyuki,Tachikawa Masanori,Hosoya Ken-ichi
Biological and Pharmaceutical Bulletin 38(7), 1087-1091, 2015
… The purpose of this study was to elucidate the transport mechanism(s) of L-glutamate (L-Glu), a neuroexcitatory neurotransmitter, in the inner blood–retinal barrier (BRB). … The L-Glu transport was evaluated by an in vitro uptake study with a conditionally-immortalized rat retinal capillary endothelial cell line, TR-iBRB2 cells. …
NAID 130005086298

Involvement of Cationic Amino Acid Transporter 1 in L-Arginine Transport in Rat Retinal Pericytes

Zakoji Nobuyuki,Akanuma Shin-ichi,Tachikawa Masanori [他],Hosoya Ken-ichi
Biological and Pharmaceutical Bulletin 38(2), 257-262, 2015
… This process was strongly inhibited by substrates of cationic amino acid transporters (CAT), such as L-ornithine and L-lysine. … In contrast, L-valine, L-leucine, and L-glutamine, which are substrates of cation/neutral amino acid transport systems, such as system y+L, system B0,+, and system b0,+, did not strongly inhibit L-Arg uptake by TR-rPCT1 cells. …
NAID 130004872256

Evidence of LAT1 expression in canine caput epididymis

OGIHARA Kikumi,ONDA Ken,SATO Reiichiro,NAYA Yuko,OCHIAI Hideharu
Journal of Veterinary Medical Science 77(1), 85-88, 2015
… L-type amino acid transporter 1 (LAT1), the first isotype of amino acid transport system L, transports aromatic and branched amino acids pivotal for fundamental cellular activities such cellular growth and proliferation. …
NAID 130004781023