amino acid metabolism defects

出典: meddic

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  • Targeting arginine metabolism pathway to treat arginine-dependent cancers.
  • Qiu F1, Huang J2, Sui M3.
  • Cancer letters.Cancer Lett.2015 Aug 1;364(1):1-7. doi: 10.1016/j.canlet.2015.04.020. Epub 2015 Apr 23.
  • The significant disparities in metabolism between tumor and normal cells have inspired the development of metabolism-based anti-tumor therapeutics. Arginine is a semi-essential amino acid because normal cells can not only synthesize arginine de novo but also take up extracellular arginine. Several t
  • PMID 25917076
  • Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV taking antiretroviral therapy: a cross-sectional pilot study.
  • Cade WT1, Singh GK2, Holland MR3, Reeds DN4, Overton ET4, Cibulka N5, Bahow K1, Presti R4, Stephens A6, Cahill AG6.
  • Clinical nutrition ESPEN.Clin Nutr ESPEN.2015 Aug 1;10(4):e140-e146.
  • BACKGROUND: Despite the success of combination antiretroviral therapy (cART) for the prevention of mother to child transmission of HIV, infants exposed to cART in utero frequently are born smaller and have mild cardiac abnormalities. The mechanisms responsible for lower birth weight and cardiac abno
  • PMID 26273702


  • ショウジョウバエ初期胚で起こる同調的核分裂におけるRecQ5の役割
  • 桜井 晴奈
  • YAKUGAKU ZASSHI 131(10), 1461-1464, 2011
  • … There are 5 RecQ homologs in mammals, and defects in 3 of them (BLM, WRN, and RECQL4) give rise to cancer predisposition syndromes in humans. … Although no human disease has yet been genetically linked to a mutation in RecQ5, this enzyme is thought to have unique functions, based on its ubiquitous expression profile and specific C-terminal amino acid sequence, both of which are very different from those of other RecQ DNA helicase family members. …
  • NAID 130001246166
  • ホモシステイン代謝
  • 橋本 隆男,篠原 佳彦,長谷川 弘
  • 藥學雜誌 127(10), 1579-1592, 2007-10-01
  • … Homocysteine, a sulfur amino acid, is an intermediate metabolite of methionine. … It can be caused by genetic defects in the enzymes involved in homocysteine metabolism or nutritional deficiencies in vitamin cofactors, certain medications or renal disease. … In this article, we review the biochemical, experimental and clinical studies on hyperhomocysteinemia, with emphasis on the metabolism and pharmacokinetics of homocysteine. …
  • NAID 110006402946


DISORDERS OF AMINO ACID METABOLISM This is a group of inherited defects of the degradation of amino acids. They include the urea cycle disorders, in which the defect involves conversion of the amino group to ...
1. Handb Clin Neurol. 2013;113:1755-73. doi: 10.1016/B978-0-444-59565-2.00046-0. Defects in amino acid catabolism and the urea cycle. Hoffmann GF(1), Kölker S. Author information: (1)Department of General Pediatrics ...






  • n.
aberrantaberrantlyaberrationabnormalabnormalityabnormallyabsenceagenesisanomalousanomalouslyanomalydefectivedeficiencydeficientdeficitdeletiondeletionaldeviantdrawbackextraordinarilyextraordinaryfaultflawinadequacymissmissingmorphological defectshortcomingunusualunusuallyweakness

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「desert (a cause, a country or an army), often in order to join the opposing cause, country, or army; "If soldiers deserted Hitler''s army, they were shot"」

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「an imperfection in an object or machine; "a flaw caused the crystal to shatter"; "if there are any defects you should send it back to the manufacturer"」
fault, flaw

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「an imperfection in a bodily system; "visual defects"; "this device permits detection of defects in the lungs"」

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「a failing or deficiency; "that interpretation is an unfortunate defect of our lack of information"」

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「〈C〉『欠点』,弱点,欠陥 / 〈U〉〈C〉《古》不足,欠乏 / (国・党・主義などから)離脱する,裏切って出る《+『from』+『名』》;離反して(…に)転向する《+『to』+『名』》」



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「street name for lysergic acid diethylamide」
back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen

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「any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt」

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「having the characteristics of an acid; "an acid reaction"」

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「酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD」


  [★] アミノ

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「pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia」

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「the radical -NH2」
amino group


  [★] 代謝

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「the organic processes (in a cell or organism) that are necessary for life」
metabolic process

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