amifostine

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/17 18:23:10」(JST)

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英文文献

  • Melatonin can Ameliorate Radiation-Induced Oxidative Stress and Inflammation-Related Deterioration of Bone Quality in Rat Femur.
  • Çakir ZÜ1, Demirel C2, Kilciksiz SC3, Gürgül S4, Zincircioğlu SB5, Erdal N6.
  • Inflammation.Inflammation.2016 Jun;39(3):1134-40. doi: 10.1007/s10753-016-0347-x.
  • The aim of the present study was to evaluate the radioprotective effects of melatonin on the biomechanical properties of bone in comparison to amifostine (WR-2721). Forty Sprague Dawley rats were divided equally into 5 groups namely; control (C), irradiation (R; single dose of 50 Gy), irradiation�
  • PMID 27052631
  • The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line.
  • Wang HT1,2,3, Yang B1, Hu B2,4, Chi XH5, Luo LL2, Yang HQ1, Lang XL2, Geng J2, Qiao CX2, Li Y2, Wu XX3, Zhu HL1, Lv M2, Lu XC1.
  • Cancer medicine.Cancer Med.2016 May 26. doi: 10.1002/cam4.759. [Epub ahead of print]
  • Amifostine is a cytoprotective drug that was initially used to control and treat nuclear radiation injury and is currently used to provide organ protection in cancer patients receiving chemotherapy. Clinical studies have also found that amifostine has some efficacy in the treatment of cytopenia caus
  • PMID 27228575
  • Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy.
  • Yang X1, Ding Y2, Ji T2, Zhao X2, Wang H2, Zhao X2, Zhao R2, Wei J3, Qi S4, Nie G5.
  • Biochemical pharmacology.Biochem Pharmacol.2016 May 15;108:11-21. doi: 10.1016/j.bcp.2016.02.014. Epub 2016 Mar 2.
  • Amifostine, an organic thiophosphate prodrug, has been clinically utilized for selective protection of normal tissues with high expression of alkaline phosphatase from oxidative damage elicited by chemotherapy or radiotherapy. However, the patients receiving amifostine suffer from severe dose-depend
  • PMID 26944193

和文文献

  • Amifostine Modulates Radio-induced Apoptosis of Peripheral Blood Lymphocytes in Head and Neck Cancer Patients
  • SAAVEDRA Maite M.,HENRIQUEZ-HERNANDEZ Luis Alberto,LARA Pedro C.,PINAR Beatriz,RODRIGUEZ-GALLEGO Carlos,LLORET Marta
  • Journal of radiation research 51(5), 603-607, 2010-09-16
  • … One of the strategies aimed at decreasing radiation toxicity is the use of radioprotective agents, such as amifostine. … The aim of the present study was to explore the effects of amifostine on the radiation-induced apoptosis of peripheral blood lymphocytes from patients suffering head and neck cancer. … Peripheral blood lymphocytes were isolated before and after the treatment with amifostine. …
  • NAID 10026644550
  • Effect of Preliminary Amifostine Administration in Irradiation of Parotid Glands
  • YACHI Yoshifumi,NASU Masanori,YOSUE Takashi
  • Oral science international : official journal of the Japanese Stomatological Society 5(2), 104-111, 2008-11-01
  • NAID 10027107198

関連リンク

与太話その57 Amifostineについて Amifostine(商品名Ethyol)は何十年も前、放射線防護を目的に軍事用に開発されたと記憶しています。現在のところ、効能として放射線防護作用を認められているものは多分、Amifostineしかないと ...
(am-i-FOS-teen) Trade names: Ethyol ® Chemocare.com uses generic names in all descriptions of drugs. Ethyol is the trade name for amifostine. In some cases, health care professionals may use the trade name ethyol ...

関連画像

amifostine crystalline 500 mg IV Solution Mechanism of action of amifostineAmifostine Makes RadiationFigure 3: Partial-amifostine (HE, Original Natfost - Ethyol (Amifostine)Amifostine = WR-2721


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  • 放射線治療の副作用を抑える放射線防護剤


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