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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/08 12:17:02」(JST)
[Wiki en表示]
Amfenac
|
| Systematic (IUPAC) name |
2-Amino-3-benzoylphenylacetic acid
2-Amino-3-benzoylbenzeneacetic acid
2-(2-amino-3-benzoyl-phenyl)acetic acid |
| Clinical data |
| Pregnancy cat. |
? |
| Legal status |
? |
| Identifiers |
| CAS number |
51579-82-9 Y |
| ATC code |
None |
| PubChem |
CID 2136 |
| ChemSpider |
2051 Y |
| UNII |
28O5C1J38A Y |
| KEGG |
D07443 Y |
| ChEMBL |
CHEMBL25146 Y |
| Chemical data |
| Formula |
C15H13NO3 |
| Mol. mass |
255.27 g/mol |
SMILES
- O=C(c1cccc(c1N)CC(=O)O)c2ccccc2
|
InChI
-
InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18) Y
Key:SOYCMDCMZDHQFP-UHFFFAOYSA-N Y
|
Y (what is this?) (verify)
|
Amfenac (2-Amino-3-benzoylbenzeneacetic acid) is a non-steroidal anti-inflammatory drug with acetic acid moiety.
Chemistry[edit]
Welstead, William J.; Moran, H. Wayne; Stauffer, Harold F.; Turnbull, Lennox B.; Sancilio, Lawrence F. (1979). "Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid". Journal of Medicinal Chemistry 22 (9): 1074–9. doi:10.1021/jm00195a012. PMID 490552.
English Journal
- In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits.
- Sheppard JD1, Cockrum PC2, Justice A3, Jasek MC3.
- Ophthalmology and therapy.Ophthalmol Ther.2018 May 14. doi: 10.1007/s40123-018-0130-1. [Epub ahead of print]
- PMID 29761367
- Prostaglandin E2 Levels of Aqueous and Vitreous Humor in Ketorolac 0.4% and Nepafenac 0.1% Administered Healthy Rabbits.
- Acar U1, Acar DE2, Tanriverdi C3, Acar M4, Ozdemir O2, Erikci A5, Ornek F6.
- Ocular immunology and inflammation.Ocul Immunol Inflamm.2017 Jun;25(3):323-327. doi: 10.3109/09273948.2015.1116587. Epub 2016 Jan 14.
- PMID 26765265
- Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye.
- Chastain JE1, Sanders ME2, Curtis MA2, Chemuturi NV2, Gadd ME3, Kapin MA4, Markwardt KL5, Dahlin DC2.
- Experimental eye research.Exp Eye Res.2016 Apr;145:58-67. doi: 10.1016/j.exer.2015.10.009. Epub 2015 Oct 22.
- PMID 26474497
Japanese Journal
- 顎関節症症型別 Amfenac Sodium (Fenazox^<(R)>) と Ethy Loflazepate (Meilax^<(R)>) の併用効果について
- 坂本 一郎,依田 哲也,塚原 宏泰,森田 伸,小幡 宏一,榎本 昭二
- 日本口腔外科学会雑誌 41(3), 224-232, 1995-03-20
- … efficacy of combined treatment with amfenac sodium (150 mg/day for 14 days) and ethyl loflazepate (2 mg/day for 14 days) was clinically evaluated in 44 patients with temporomandibular disorders in comparison with 77 patients with temporomandibular disorders who were given amfenac sodium (150 mg/day for 14 days) alone.<BR>The 121 temporomandibular disorder patients were classified into four types (I-IV) according to the criteria proposed by the Japanese Society for the Temporomandibular Joint.<BR>The usefulness of …
- NAID 10006610741
- Inhibitory Effects of Non-steroidal Anti-inflammatory Drugs on Superoxide Generation
- 湯田 康勝,田中 淳子,鈴木 幸吉,五十嵐 一衛,佐藤 哲男
- Chemical & pharmaceutical bulletin 39(4), 1075-1077, 1991-04-25
- … Effects of non-steroidal anti-inflammatory drugs (NSAID : amfenac sodium, diclofenac sodium, indomethacin and ketoprofen) on the generation of superoxide anion (O^-_2) by isolated rat polymorphonuclear leukocytes (PMN) were studied spectrophotometrically using cytochrome c. …
- NAID 110003629278
- 顎関節症に対する Amfenac Sodium (フェナゾックス^<(R)>) の臨床評価.
Related Links
- Amfenac is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%.
- Amfenac is an oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac ...
- Amfenac is a medicine available in a number of countries worldwide. A list of US medications equivalent to Amfenac is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more than ...
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