クロフィブラートアルミニウム
- 関
- aluminum clofibrate
WordNet
- a drug (trade name Atromid-S) that reduces lipids in the blood serum; used to treat some cardiovascular diseases (同)Atromid-S
PrepTutorEJDIC
- 《英》=aluminum
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/25 14:23:23」(JST)
[Wiki en表示]
Aluminium clofibrate
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| Clinical data |
| MedlinePlus |
a699047 |
| ATC code |
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| Pharmacokinetic data |
| Metabolism |
Hydrolyzed to clofibric acid and aluminium hydroxide |
| Excretion |
Renal |
| Identifiers |
IUPAC name
- Aluminium bis(2-(4-chlorophenoxy)-2-methylpropanoate) hydroxide
|
| CAS Number |
|
| PubChem CID |
|
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| ECHA InfoCard |
100.042.237 |
| Chemical and physical data |
| Formula |
C20H24Cl2O7 |
| Molar mass |
474.287 g/mol |
| 3D model (JSmol) |
|
SMILES
-
Clc2ccc(OC(C)(C)C(=O)O[Al](O)OC(=O)C(C)(C)Oc1ccc(Cl)cc1)cc2
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InChI
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InChI=1S/2C10H11ClO3.Al.H2O/c2*1-10(2,9(12)13)14-8-5-3-7(11)4-6-8;;/h2*3-6H,1-2H3,(H,12,13);;1H2/q;;+3;/p-3 Y
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Key:USWVMPGQVYZHCA-UHFFFAOYSA-K Y
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| NY (what is this?) (verify) |
Aluminium clofibrate (or alfibrate) is a fibrate.
See also
References
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Lipid modifying agents (C10)
|
| GI tract |
| Cholesterol absorption inhibitors, NPC1L1 |
|
| Bile acid sequestrants/resins (LDL) |
- Colesevelam
- Colestilan
- Colestipol
- Colestyramine
- Colextran
|
|
| Liver |
| Statins (HMG-CoA reductase, LDL) |
- Atorvastatin
- Cerivastatin‡
- Fluvastatin
- Lovastatin
- Mevastatin
- Pitavastatin
- Pravastatin
- Rosuvastatin
- Simvastatin#
|
| Niacin and derivatives (HDL and LDL) |
- Acipimox
- Aluminium nicotinate
- Niacin
- Niceritrol
- Nicofuranose
- Nicotinyl alcohol
|
| MTTP inhibitors (VLDL) |
- Dirlotapide
- Lomitapide
- Mitratapide
|
|
| Blood vessels |
| Fibrates (PPAR) |
- Aluminium clofibrate
- Bezafibrate
- Ciprofibrate
- Clinofibrate
- Clofibrate‡
- Clofibride
- Etofibrate
- Fenofibrate
- Gemfibrozil
- Pemafibrate
- Ronifibrate
- Simfibrate
|
| CETP inhibitors (HDL) |
- Anacetrapib†
- Dalcetrapib§
- Evacetrapib§
- Obicetrapib†
- Torcetrapib§
|
| PCSK9 inhibitors (LDL) |
- Alirocumab
- Bococizumab
- Evolocumab
|
|
| Combinations |
- Ezetimibe/atorvastatin
- Ezetimibe/simvastatin
- Niacin/laropiprant
- Niacin/lovastatin
- Niacin/simvastatin
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| Other |
- Alipogene tiparvovec
- Azacosterol
- Azalanstat
- Benfluorex‡
- Darapladib§
- Dextrothyroxine‡
- Lapaquistat§
- Magnesium pyridoxal 5-phosphate glutamate
- Meglutol
- Mipomersen
- Omega-3-triglycerides
- Policosanol
- Probucol
- Tiadenol
- Triparanol‡
- Volanesorsen†
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
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English Journal
- Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate.
- Takagi A1, Sai K, Umemura T, Hasegawa R, Kurokawa Y.
- Cancer letters.Cancer Lett.1990 Aug;53(1):33-8.
- To elucidate the relationship between hepatic peroxisome proliferation and oxidative DNA damage induced by hepatocarcinogenic peroxisome proliferators, 3 agents, namely, di(2-ethylhexyl) phthalate (DEHP, aluminium clofibrate and simfibrate were fed at doses of 1.2%, aluminium clofibrate 0.5% and 0.5
- PMID 2397479
- The antilipemic effectiveness of aluminium clofibrate on hyperlipidemic patients with or without diabetes mellitus.
- Lam HC, Li SH, Wang JT, Tang KT, Ho LT.
- Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.Zhonghua Yi Xue Za Zhi (Taipei).1987 Nov;40(5):463-70.
- PMID 3332236
- Plasma clofibric acid (CPIB) levels induced by three marketed compounds releasing clofibric acid, in volunteers.
- Harvengt C, Desager JP.
- International journal of clinical pharmacology and biopharmacy.Int J Clin Pharmacol Biopharm.1977 Jan;15(1):1-4.
- The very low plasma clofibric acid levels achieved in normolipemic volunteers during 96 h by a single dose of alufibrate (basic aluminum salt of clofibric acid) as 4 x 360 mg tablets, have been confirmed. With a crossover study in healthy volunteers receiving therapeutic doses of clofibrate as 2x500
- PMID 576423
Japanese Journal
- 高脂血症, 低HDL-C血症におけるエラスターゼの使用経験
- 今泉 信作,田村 康二
- 動脈硬化 11(2), 387-395, 1983
- … g. Pantethine, Pentaerythritol tetranicotinate, and Aluminium clofibrate, the effectiveness of Elastase was slightly lower than that of Pentaerythritol tetranicotinate and Aluminium clofibrate.9) No severe side effects by this drug were found. …
- NAID 130004882755
- 齊藤 昇,松下 紀美子
- 動脈硬化 10(4), 677-683, 1982
- … By administration of aluminium clofibrate for one month, serum HDL-C tended to increase, and TG tended to decrease in 23 cases with glucose intolerance. …
- NAID 130004882634
- 糖尿病患者の高脂血症に対するaluminium clofibrateの効果
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