関: alprenolol hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/27 09:58:07」(JST)

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Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as 5-HT_1A receptor antagonist, used in the treatment of angina pectoris.^[1] It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.

References

^ Hickie JB (August 1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. PMID 4393977.

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English Journal

Quantification of alprenolol and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC).

Gonçalves VMF1, Rodrigues P1, Ribeiro C2, Tiritan ME3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2017 Jul 15;141:1-8. doi: 10.1016/j.jpba.2017.03.064. Epub 2017 Apr 2.
PMID 28412606

Antilipolytic effects of 1,8-naphthyridine derivatives β-adrenoceptor antagonists in rat white adipocytes.

Aljamal JA1, Badawneh M1.
Chemical biology & drug design.Chem Biol Drug Des.2017 Jul;90(1):119-127. doi: 10.1111/cbdd.12933. Epub 2017 Feb 11.
PMID 28054456

Chemometric evaluation of the combined effect of temperature, pressure, and co-solvent fractions on the chiral separation of basic pharmaceuticals using actual vs set operational conditions.

Forss E1, Haupt D1, Stålberg O1, Enmark M1, Samuelsson J2, Fornstedt T3.
Journal of chromatography. A.J Chromatogr A.2017 May 26;1499:165-173. doi: 10.1016/j.chroma.2017.03.077. Epub 2017 Mar 28.
PMID 28389095

Japanese Journal

Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol.

Frontiers in pharmacology 4, 150, 2013-01-01
NAID 120005541898

Influence of Lipid Composition on the Structural Stability of G-Protein Coupled Receptor

Chemical and Pharmaceutical Bulletin 61(4), 426-437, 2013
NAID 130003360753

Labeling of alprenolol with fluorescent aryl iodide as a reagent based on Mizoroki-Heck coupling reaction.

Journal of Chromatography. A 1218(20), 3002-3006, 2011-05-20
NAID 120003238480

Related Pictures

★リンクテーブル★

リンク元	「アルプレノロール」
拡張検索	「alprenolol hydrochloride」「dihydroalprenolol」

「アルプレノロール」

Alprenolol
Systematic (IUPAC) name
	(RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Administration	Oral
Pharmacokinetic data
Protein binding	80% - 90%
Biological half-life	2-3 hours → 4-OH-alprenolol
Identifiers
CASRN	13655-52-2
ATC code	C07AA01 (WHO)
PubChem	CID 2119
IUPHAR/BPS	563
DrugBank	DB00866
ChemSpider	2035
UNII	877K5MQ27W
KEGG	D07156
ChEBI	CHEBI:51211
ChEMBL	CHEMBL266195
Chemical data
Formula	C15H23NO2
Molar mass	249.34 g/mol
	SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C ;
	InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 ; Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N ;
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