WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
an inherited form of anemia caused by faulty synthesis of hemoglobin (同)thalassaemia, Mediterranean_anemia, Mediterranean anaemia
any high mountain

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Changes in hematological parameters in α-thalassemia individuals co-inherited with erythroid Krüppel-like factor mutations.

Yu LH1, Liu D1, Cai R2, Shang X1, Zhang XH3, Ma XX1, Yan SH4, Fang P1, Zheng CG5, Wei XF1, Liu YH6, Zhou TB7, Xu XM1.
Clinical genetics.Clin Genet.2015 Jul;88(1):56-61. doi: 10.1111/cge.12443. Epub 2014 Jul 26.
Phenotypic variations in α-thalassemia mainly depend on the defective α-globin gene number. Genetic modifiers of the phenotype of Hemoglobin H (HbH) disease were poorly reported, apart from β-thalassemia allele that was identified ameliorating the severity of α-thalassemia. Because erythroid Kr�
PMID 24930900

Multi-allele DNA biosensor for the rapid genotyping of 'nondeletion' alpha thalassaemia mutations in HBA1 and HBA2 genes by means of multiplex primer extension reaction.

Petropoulou M1, Poula A1, Traeger-Synodinos J2, Kanavakis E2, Christopoulos TK3, Ioannou PC4.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2015 Jun 15;446:241-7. doi: 10.1016/j.cca.2015.04.016. Epub 2015 Apr 17.
BACKGROUND: Alpha-thalassaemia is an autosomal recessive disorder characterized by defective production of the alpha chain of haemoglobin. It is caused mainly by deletions of one or both of the duplicated alpha-globin genes on chromosome 16, and/or by nucleotide variations, known as "nondeletion" mu
PMID 25892676

Mettananda S1, Gibbons RJ2, Higgs DR3.
Blood.Blood.2015 Jun 11;125(24):3694-3701. Epub 2015 Apr 13.
The thalassemias, together with sickle cell anemia and its variants, are the world's most common form of inherited anemia, and in economically undeveloped countries, they still account for tens of thousands of premature deaths every year. In developed countries, treatment of thalassemia is also stil
PMID 25869286

出口幸一,曺英樹,米田光宏 [他],田附裕子,山中宏晃,野村元成,松浦玲,福澤正洋
日本小児外科学会雑誌 51(2), 240-245, 2015
横行結腸軸捻転症はまれな結腸捻転症の1 つであるが，小児例においては脳性麻痺や精神運動発達遅滞児の占める割合が高いことが知られている．我々はATR-X 症候群に発症した横行結腸軸捻転症の1 例を経験した．症例は17 歳，男児．3 歳時にATR-X 症候群と診断された．腹部膨満，経口摂取不良のため緊急入院となった．下部消化管造影検査にて横行結腸左側で造影剤の途絶を認め，CT にて横行結腸軸捻転と診断 …
NAID 130005065241

Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors

Sato Shoki,Tsuchikawa Takahiro,Nakamura Toru,Sato Nagato,Tamoto Eiji,Okamura Keisuke,Shichinohe Toshiaki,Hirano Satoshi
Oncology reports 32(6), 2753-2759, 2014-12
… The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PHR using immunohistochemical analysis for tumor-infiltrating lymphocytes (TILs: CD3, CD8 and CD45RO), human leukocyte antigen (HLA) class I, alpha-thalassemia/mental retardation X-linked (ATRX), death domain-associated protein (DAXX), mammalian target of rapamycin (mTOR) and phospho-mTOR (p-mTOR). …
NAID 120005617277