alpha-secretase

出典: meddic

αセクレターゼ

amyloid precursor protein secretasebeta-secretasegamma-secretasesecretase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/26 23:10:45」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Honokiol inhibits melanoma stem cells by targeting notch signaling.
  • Kaushik G1, Venugopal A2, Ramamoorthy P2,3, Standing D2, Subramaniam D2,3, Umar S2,3, Jensen RA4,3, Anant S1,2,3, Mammen JM1,3.
  • Molecular carcinogenesis.Mol Carcinog.2015 Dec;54(12):1710-21. doi: 10.1002/mc.22242. Epub 2014 Dec 9.
  • Melanoma is an aggressive disease with limited therapeutic options. Here, we determined the effects of honokiol (HNK), a biphenolic natural compound on melanoma cells and stemness. HNK significantly inhibited melanoma cell proliferation, viability, clonogenicity and induced autophagy. In addition, H
  • PMID 25491779
  • A Fluorescent Analog of Batimastat Enables Imaging of α-Secretase in Living Cells.
  • Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J.
  • ACS chemical neuroscience.ACS Chem Neurosci.2015 Nov 11. [Epub ahead of print]
  • The ADAM family of metalloproteases cleave a diverse range of transmembrane substrates, resulting in the release of their soluble ectodomains. This process of protein shedding, termed α-secretase processing, is involved in many facets of both normal and disease related cellular function. While the
  • PMID 26559179
  • Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease.
  • Bianco OA1, Manzine PR1, Nascimento CM1, Vale FA2, Pavarini SC1, Cominetti MR1.
  • International psychogeriatrics / IPA.Int Psychogeriatr.2015 Nov 11:1-6. [Epub ahead of print]
  • BACKGROUND: Studies have demonstrated a decreased platelet ADAM10 expression in patients with Alzheimer's Disease (AD), classifying this protein as a blood-based AD biomarker. About 50% of the patients with AD are diagnosed with depression, which is commonly treated with tricyclic and tetracyclic an
  • PMID 26555131

和文文献

  • The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments
  • Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

関連リンク

1. Curr Alzheimer Res. 2012 Feb;9(2):165-77. Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking. Lichtenthaler SF(1). Author ...
1. Curr Alzheimer Res. 2008 Apr;5(2):179-86. A closer look at alpha-secretase. Postina R. Institute of Biochemistry, Johannes Gutenberg University Mainz, Becherweg 30, 55099 Mainz, Germany. postina@uni-mainz.de ...

関連画像

Alpha Secretasealpha secretase APP processing via alpha-secretaseAlpha secretaseAlpha-Secretase Cleavage of the Amyloid  cleaved by either alpha or beta secretase


★リンクテーブル★
リンク元amyloid precursor protein secretase」「αセクレターゼ」「beta-secretase」「gamma-secretase」「α-セクレターゼ
関連記事alpha」「secretase」「alp」「secreta

amyloid precursor protein secretase」

  [★]

アミロイド前駆タンパク質セクレターゼアミロイド前駆タンパク質分泌酵素

alpha-secretasebeta-secretasegamma-secretasesecretase

αセクレターゼ」

  [★]

alpha-secretase
セクレターゼγセクレターゼアミロイド前駆タンパク質分泌酵素βセクレターゼα-セクレターゼ


beta-secretase」

  [★]

βセクレターゼ

alpha-secretaseamyloid precursor protein secretaseBACEbeta-site APP cleaving enzymegamma-secretasesecretase

gamma-secretase」

  [★]

γセクレターゼ

alpha-secretaseamyloid precursor protein secretasebeta-secretasesecretase


α-セクレターゼ」

  [★]

alpha-secretase
αセクレターゼ


alpha」

  [★]

αアルファ

alfa

WordNet   license wordnet

「first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"」

WordNet   license wordnet

「the 1st letter of the Greek alphabet」

WordNet   license wordnet

「the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations」

PrepTutorEJDIC   license prepejdic

「アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)」

WordNet   license wordnet

「early testing stage of a software or hardware product; "alpha version"」

secretase」

  [★]


WordNet   license wordnet

「a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer''s)」


alp」

  [★]

WordNet   license wordnet

「any high mountain」

PrepTutorEJDIC   license prepejdic

「高山,高峰」


secreta」

  [★]

juicesecretory fluid




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡