WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
any high mountain

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1. α-1アンチトリプシン欠乏の治療 treatment of alpha 1 antitrypsin deficiency
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5. α-1アンチトリプシン欠乏症の臨床症状、診断、および自然経過 clinical manifestations diagnosis and natural history of alpha 1 antitrypsin deficiency

Durek T1, Craik DJ1.
Expert opinion on therapeutic patents.Expert Opin Ther Pat.2015 Oct;25(10):1159-73. doi: 10.1517/13543776.2015.1054095. Epub 2015 Jun 12.
INTRODUCTION: Conotoxins are a large family of bioactive peptides derived from cone snail venom. They target specific classes of ion channels and other membrane proteins and may have therapeutic value, primarily in the management of pain.AREAS COVERED: The authors surveyed the US patent literature c
PMID 26065897

Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors.

Xu S1, Zhang T2, Kompella SN3, Yan M1, Lu A1, Wang Y1, Shao X1, Chi C1,2, Adams DJ3, Ding J2, Wang C1.
Scientific reports.Sci Rep.2015 Sep 23;5:14261. doi: 10.1038/srep14261.
Nicotinic acetylcholine receptors (nAChRs) play essential roles in transmitting acetylcholine-mediated neural signals across synapses and neuromuscular junctions, and are also closely linked to various diseases and clinical conditions. Therefore, novel nAChR-specific compounds have great potential f
PMID 26395518

An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation.

Prashanth JR1, Lewis RJ2.
Toxicon : official journal of the International Society on Toxinology.Toxicon.2015 Sep 14. pii: S0041-0101(15)30072-6. doi: 10.1016/j.toxicon.2015.09.012. [Epub ahead of print]
Transcriptome sequencing is now widely adopted as an efficient means to study the chemical diversity of venoms. To improve the efficiency of analysis of these large datasets, we have optimised an analysis pipeline for cone snail venom gland transcriptomes. The pipeline combines ConoSorter with seque
PMID 26376071

Point Mutations of Alpha-Conotoxin PnIA to Characterise Subtypes of Human and Rat Nicotinic Acetylcholine Receptors

HOPPING Gene,HOGG Ron C.,BETRAND Daniel,ADAMS David J.,LEWIS Richard J.,ALEWOOD Paul F.
Peptide science : proceedings of the ... Japanese Peptide Symposium 2004, 581-582, 2005-03-01
NAID 10014460640