関: chloralose

WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
any high mountain

PrepTutorEJDIC

アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
高山,高峰

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/03 23:08:10」(JST)

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Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.^[1]

Chemically, it is a chlorinated acetal derivative of glucose.

It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)

References

^ Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.

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1. 殺鼠剤中毒の概要 overview of rodenticide poisoning

English Journal

Preconditioning cortical lesions reduce the incidence of peri-infarct depolarizations during focal ischemia in the Spontaneously Hypertensive Rat: interaction with prior anesthesia and the impact of hyperglycemia.

Zhao L1, Nowak TS Jr1.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2015 Mar 11. doi: 10.1038/jcbfm.2015.37. [Epub ahead of print]
The relationship between peri-infarct depolarizations (PIDs) and infarction was investigated in a model of preconditioning by cortical freeze lesions (cryogenic lesions, CL) in the Spontaneously Hypertensive Rat. Small (< 5 mm3) lesions produced 24 hours before permanent focal ischemia were p
PMID 25757750

Intrarenal bradykinin elicits reno-renal reflex sympatho-excitation and renal nerve-dependent fluid retention.

Barry EF1, Johns EJ.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2015 Mar;213(3):731-9. doi: 10.1111/apha.12420. Epub 2014 Nov 20.
AIMS: The renal sensory nerves are importantly involved in the sympathetic regulation of cardiovascular and renal function. Two reno-renal reflexes are recognized, one in which activation of renal sensory nerves elicits a renal sympatho-inhibition, and one which causes a renal sympatho-excitation an
PMID 25369876

Robust deep brain stimulation functional MRI procedures in rats and mice using an MR-compatible tungsten microwire electrode.

Lai HY1, Albaugh DL, Kao YC, Younce JR, Shih YY.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.Magn Reson Med.2015 Mar;73(3):1246-51. doi: 10.1002/mrm.25239. Epub 2014 May 5.
PURPOSE: To develop a series of robust and readily adoptable protocols for the application of deep brain stimulation (DBS)-functional MRI (fMRI) in rodents.METHODS: DBS-fMRI procedures were conducted in rat and mouse under varying anesthetic conditions (isoflurane in rat and mouse, α-chloralose in
PMID 24798216

Japanese Journal

Effects of Head-Down Tilt on Cerebral Blood Flow and Somatosensory-Evoked Potentials in Rabbits.

Asai Yasumasa,Inoue Sadanori,Tatebayashi Kyouko,Shiraishi Yoshimitsu,Kawai Yasuaki
The Japanese Journal of Physiology 52(1), 105-110, 2002
… The animals were anesthetized with alpha chloralose and the lungs were artificially ventilated. …
NAID 130004435824

Crossed and Uncrossed Segmental Synaptic Effects on Rectus Abdominis Motoneurons from Cutaneous and Cutaneous-Muscle Nerve in Spinal Cats and .ALPHA.-Chloralose-Anesthetized Cats.

中田亜紀,城崎明徳,徳力幹彦
Journal of Veterinary Medical Science 56(3), 511-516, 1994
第1腰髄節に入る, 背側皮膚・皮筋神経(体幹背側部に分布)と腹側皮膚・皮筋神経(体幹腹側部に分布)を電気刺激して, 第1腰髄節に存在する腹直筋運動ニューロンの髄節性シナプス応答を細胞内記録法により調べた. この髄節性反射経路に対する, 上部脊髄ならびに脳からの下行性入力の影響を調べるために, 脊髄猫(49頭)とアルファ・クロラローズ麻酔猫(28頭)を用いた. 同側ないし対側からの背側皮膚・皮筋神経 …
NAID 130003571952

Crossed and Uncrossed Segmental Synaptic Effects on Obliquus Externus Abdominis Motoneurons from Cutaneous and Cutaneous-Muscle Nerve in Spinal Cats and .ALPHA.-Chloralose-Anesthetized Cats.

中田亜紀,城崎明徳,平田なおみ,徳力幹彦
Journal of Veterinary Medical Science 56(3), 503-509, 1994
体幹に分布し, 第1腰髄節に入る背側皮膚・皮筋神経と腹側皮膚・皮筋神経を電気刺激することによって, 第1腰髄節に存在する外腹斜筋運動ニューロンのシナプス応答を, 細胞内記録法により調べた. この髄節性皮膚反射経路に, 上部脊髄ならびに脳からの下行性入力がどのような影響を与えているかを調べるために, 第4胸髄を切断した脊髄猫(49頭)とアルファ・クロラローズ麻酔猫(28頭)を用いた. 記録側ならびに …
NAID 130003571951

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リンク元	「αクロラロース」「α-クロラロース」
関連記事	「alpha」「chloralose」

「αクロラロース」

Chloralose
Names
	IUPAC name (5ξ)-1,2-O-[2,2,2-Trichloroethylidene]-α-xylo-hexofuranose
Identifiers
CAS Number	15879-93-3
Beilstein Reference	85418
ChEMBL	ChEMBL2104181
ChemSpider	5414376
EC Number	240-016-7
Jmol 3D model	Interactive image
KEGG	C18707
MeSH	Chloralose
PubChem	7057995; 40467114 (2R,3aR,5R,6R)-6-hydroxy-2-methyl-furo-5-yl; 27525 (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl; 16211632 (1R)-dioxol, (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl; 186624 (1R)-dioxol, (3aR,5R,6S,6aR)-6-hydroxy-furo-5-yl; 2723807 (2R,3aR,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl; 85991
RTECS number	FM9450000
UNII	238BZ29MUE
	InChI InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 Key: OJYGBLRPYBAHRT-IPQSZEQASA-N ; InChI=1/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 Key: OJYGBLRPYBAHRT-IPQSZEQABF ;
	SMILES C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O ;
Properties
Chemical formula	C8H11Cl3O6
Molar mass	309.52 g·mol−1
Melting point	176 to 182 °C (349 to 360 °F; 449 to 455 K)
Hazards
Main hazards	Harmful if swallowed; Harmful if inhaled
EU classification (DSD)	Xn
R-phrases	R20/22
S-phrases	(S2) S16 S24/25 S28
Related compounds
Related compounds	Chloral hydrate
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references