αカテニン
WordNet
- first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
- the 1st letter of the Greek alphabet
- the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
- early testing stage of a software or hardware product; "alpha version"
- any high mountain
PrepTutorEJDIC
- アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
- 高山,高峰
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/13 05:25:00」(JST)
[Wiki en表示]
| catenin (cadherin-associated protein), alpha 1, 102kDa |
|
Model of human aldehyde oxidase after PDB: 1H6G
|
| Identifiers |
| Symbol |
CTNNA1 |
| Entrez |
1495 |
| HUGO |
2509 |
| OMIM |
116805 |
| RefSeq |
NM_001903 |
| UniProt |
P35221 |
| Other data |
| Locus |
Chr. 5 q31.2 |
| catenin (cadherin-associated protein), alpha 2 |
| Identifiers |
| Symbol |
CTNNA2 |
| Entrez |
1496 |
| HUGO |
2510 |
| OMIM |
114025 |
| RefSeq |
NM_004389 |
| UniProt |
P26232 |
| Other data |
| Locus |
Chr. 2 p12-p11.1 |
| catenin (cadherin-associated protein), alpha 3 |
| Identifiers |
| Symbol |
CTNNA3 |
| Entrez |
29119 |
| HUGO |
2511 |
| OMIM |
607667 |
| RefSeq |
NM_013266 |
| UniProt |
Q9UI47 |
| Other data |
| Locus |
Chr. 10 q21 |
Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton.[1] It has been reported that the actin binding proteins vinculin[2] and alpha-actinin[3] can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time.[4] It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.[5]
The amino acid sequence of alpha-catenin has sequence similarity to that of vinculin.[6]
Contents
- 1 Types
- 2 See also
- 3 External links
- 4 References
Types
There are three human alpha-catenin genes:
- alpha-1-catenin (also called alpha-E-catenin)
- alpha-2-catenin (also called alpha-N-catenin)
- alpha-3-catenin (also called alpha-T-catenin)
See also
External links
- alpha Catenin at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Cooper, Geoffrey M. (2000). "Figure 11.14: Model of attachment of actin filaments to catenin-cadherin complexes". The Cell: A Molecular Approach (2nd ed.). Sinauer Associates. ISBN 0-87893-219-4.
- ^ Watabe-Uchida M, Uchida N, Imamura Y, et al. (August 1998). "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells". J. Cell Biol. 142 (3): 847–57. PMC 2148175 . PMID 9700171. doi:10.1083/jcb.142.3.847.
- ^ Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (July 1995). "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin". J. Cell Biol. 130 (1): 67–77. PMC 2120515 . PMID 7790378. doi:10.1083/jcb.130.1.67.
- ^ Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ (December 2005). "Deconstructing the cadherin-catenin-actin complex". Cell. 123 (5): 889–901. PMC 3368712 . PMID 16325582. doi:10.1016/j.cell.2005.09.020.
- ^ Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI (December 2005). "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly". Cell. 123 (5): 903–15. PMC 3369825 . PMID 16325583. doi:10.1016/j.cell.2005.09.021.
- ^ Nagafuchi A, Takeichi M, Tsukita S (May 1991). "The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression". Cell. 65 (5): 849–57. PMID 1904011. doi:10.1016/0092-8674(91)90392-C.
|
Proteins of the cytoskeleton
|
| Human |
|
| Nonhuman |
- Major sperm proteins
- Prokaryotic cytoskeleton
|
|
See also: cytoskeletal defects
|
UpToDate Contents
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English Journal
- CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.
- Kapur N1, Mir H1, Clark Iii CE2, Krishnamurti U3, Beech DJ2, Lillard JW1, Singh S1.
- British journal of cancer.Br J Cancer.2016 May 5. doi: 10.1038/bjc.2016.113. [Epub ahead of print]
- BACKGROUND: Adjuvant chemotherapy offered to treat colon cancer is based on the TNM staging system, which often fails due to molecular heterogeneity and undefined molecular mechanisms independent of TNM. Therefore, identification of markers to better predict therapeutic option and outcome is needed.
- PMID 27149649
- High expression of hexokinase domain containing 1 is associated with poor prognosis and aggressive phenotype in hepatocarcinoma.
- Zhang Z1, Huang S1, Wang H2, Wu J1, Chen D3, Peng B1, Zhou Q4.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 May 4. pii: S0006-291X(16)30684-2. doi: 10.1016/j.bbrc.2016.05.007. [Epub ahead of print]
- Rapid progress and metastasis remain the major treatment failure modes of hepatocarcinoma (HCC). Unfortunately, the underlying molecular mechanisms of hepatoma cell proliferation and migration are poorly understood. Metabolic abnormities play critical roles in tumorigenesis and progression. Hexokina
- PMID 27155152
- Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis.
- Wang J1, Sun H2, Fu Z1, Liu M1.
- Free radical research.Free Radic Res.2016 May 4:1-14. [Epub ahead of print]
- OBJECTIVE: The purpose of this study was to investigate whether alpha-lipoic acid (ALA) confers a chondroprotective effect on articular cartilage in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA).METHODS: Fifty male SD rats were divided into five groups, including SHAM-operated,
- PMID 27055478
Japanese Journal
- Defining the Roles of .ALPHA.-Catenin in Cell Adhesion and Cytoskeleton Organization: Isolation of F9 Cells Completely Lacking Cadherin-catenin Complex
- , , , ,
- Cell Structure and Function 36(1), 131-143, 2011
- … To define the roles of α-catenin in cell-cell adhesion, the E-cadherin, α-catenin, β-catenin, and/or plakoglobin genes were inactivated in F9 teratocarcinoma cells. … An E-cadherin-α-catenin fusion protein (Eα) restored full cell-adhesion function and organized the actin-based cytoskeleton and ZO-1, an actin filament binding protein, in F9 cells lacking all endogenous cadherin-catenin complex components. …
- NAID 130004137568
- Ultrastructural localization of alpha E-catenin in the rat sciatic nerve
- Murata Maho,Shibuya Yasuyuki,Munemoto Sachiko,Takeuchi Junichiro,Kobayashi Masaki,Suzuki Hiroaki,Komori Takahide
- The Kobe journal of the medical sciences 52(3/4), 77-84, 2006
- … Alpha E-catenin is included in the same category as alpha N-catenin, and both ofthem have been identified as subtypes of alpha-catenin. …
- NAID 110004792441
- Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions
★リンクテーブル★
[★]
- 英
- alpha-catenin
- 関
- α-カテニン
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- 英
- alpha-catenin
- 関
- αカテニン
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α、アルファ
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- alfa