α-L-フコシダーゼ
- 関
- fucosidase
WordNet
- first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
- the 1st letter of the Greek alphabet
- the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
- early testing stage of a software or hardware product; "alpha version"
- the 12th letter of the Roman alphabet (同)l
- any high mountain
PrepTutorEJDIC
- アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
- lira(イタリアの貨幣単位リラ)
- 高山,高峰
- liter[s]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/03 06:58:08」(JST)
[Wiki en表示]
| Alpha-L-fucosidase |
|
crystal structure of thermotoga maritima alpha-fucosidase
|
| Identifiers |
| Symbol |
Alpha_L_fucos |
| Pfam |
PF01120 |
| Pfam clan |
CL0058 |
| InterPro |
IPR000933 |
| PROSITE |
PDOC00324 |
| SCOP |
1hl9 |
| SUPERFAMILY |
1hl9 |
| CAZy |
GH29 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
| alpha-L-fucosidase |
| Identifiers |
| EC number |
3.2.1.51 |
| CAS number |
9037-65-4 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / QuickGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction
- an alpha-L-fucoside + H2O L-fucose + an alcohol
Thus, the two substrates of this enzyme are alpha-L-fucoside and H2O, whereas its two products are L-fucose and alcohol.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.
Deficiency of this enzyme is called Fucosidosis.
In CAZy, alpha-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.
Contents
- 1 Structural studies
- 2 Human medical studies
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.
Human medical studies
It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.
See also
- 1,2-alpha-L-fucosidase
- 1,3-alpha-L-fucosidase
- 1,6-alpha-L-fucosidase
- FUCA2
References
- ^ Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E. Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients. Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x.
Further reading
- Levvy GA, Mcallan A (August 1961). "Mammalian fucosidases. 2. alpha-L-Fucosidase". The Biochemical Journal. 80 (2): 435–9. PMC 1244021 . PMID 13761578.
- Reglero A, Cabezas JA (July 1976). "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". European Journal of Biochemistry / FEBS. 66 (2): 379–87. PMID 7458. doi:10.1111/j.1432-1033.1976.tb10527.x.
- Tanaka K, Nakano T, Noguchi S, Pigman W (August 1968). "Purification of alpha-L-fucosidase of abalone livers". Archives of Biochemistry and Biophysics. 126 (2): 624–33. PMID 5672520. doi:10.1016/0003-9861(68)90449-9.
External links
- CAZy family GH29
- CAZy family GH95
|
Hydrolase: sugar hydrolases (EC 3.2)
|
| 3.2.1: Glycoside hydrolases |
| Disaccharidase |
- Sucrase/Sucrase-isomaltase/Invertase
- Maltase
- Trehalase
- Lactase
|
| Glucosidases |
- Cellulase
- Alpha-glucosidase
- Acid
- Neutral AB
- Neutral C
- Beta-glucosidase
- Debranching enzyme
|
| Other |
- Amylase
- Chitinase
- Lysozyme
- Neuraminidase
- NEU1
- NEU2
- NEU3
- NEU4
- Bacterial neuraminidase
- Viral neuraminidase
- Galactosidases
- alpha-Mannosidase
- Glucuronidase
- Hyaluronidase
- Pullulanase
- Glucosylceramidase
- Galactosylceramidase
- Alpha-N-acetylgalactosaminidase
- Alpha-N-acetylglucosaminidase
- Fucosidase
- Hexosaminidase
- Iduronidase
- Maltase-glucoamylase
- Heparanase
|
|
3.2.2: Hydrolysing
N-Glycosyl compounds |
- DNA glycosylases: Oxoguanine glycosylase
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- The potential hazardous effect of exposure to iron dust in Egyptian smoking and nonsmoking welders.
- Gobba NAEK1, Hussein Ali A2, El Sharawy DE3, Hussein MA4.
- Archives of environmental & occupational health.Arch Environ Occup Health.2018 May 4;73(3):189-202. doi: 10.1080/19338244.2017.1314930. Epub 2017 May 1.
- PMID 28375782
- Synthesis of a Fucosylated Trisaccharide Via Transglycosylation by α-L-Fucosidase from Thermotoga maritima.
- Guzmán-Rodríguez F1, Alatorre-Santamaría S1, Gómez-Ruiz L1, Rodríguez-Serrano G1, García-Garibay M1,2, Cruz-Guerrero A3.
- Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2018 May 2. doi: 10.1007/s12010-018-2771-x. [Epub ahead of print]
- PMID 29717409
- Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice.
- Stroobants S1,2, Wolf H3, Callaerts-Vegh Z1,2, Dierks T3, Lübke T3, D'Hooge R1,2.
- Frontiers in behavioral neuroscience.Front Behav Neurosci.2018 Apr 12;12:69. doi: 10.3389/fnbeh.2018.00069. eCollection 2018.
- PMID 29706874
Japanese Journal
- Structural basis of the catalytic reaction mechanism of novel 1,2-alpha-L-fucosidase from Bifidobacterium bifidum
- Purification of human alpha-L-fucosidase precursor expressed in Escherichia coli as a glutathione S-transferase fusion protein
- DE CARLOS Alejandro,MONTENEGRO Dolores,ALONSO-RODRIGUEZ Ana,PAEZ DE LA CADENA Maria,RODRIGUEZ-BERROCAL Francisco Javier,MARTINEZ-ZORZANO Vicenta Soledad
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 786(1), 7-15, 2003-03-25
- NAID 10011808548
- Prediction of the Development of Hepato-Cellular-Carcinoma in Patients with Liver Cirrhosis by the Serial Determinations of Serum Alpha-L-fucosidase Activity
- Ishizuka Hideo,Nakayama Tomoki,Matsuoka Shunichi [他],GOTOH Iori,OGAWA Masahiro,SUZUKI Kazutomo,TANAKA Naohide,TSUBAKI Kouji,OHKUBO Hitoshi,ARAKAWA Yasuyuki,OKANO Tadao
- Internal medicine 38(12), 927-931, 1999-12-01
- … Objective Evaluation of the usefulness of the serial daterminations of serum alpha-L-fucosidase (AFU) activity for prediction of the development of hepatocellular carcinoma (HCC) was performed. …
- NAID 10005531067
Related Links
- Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. ... « Hide 10 20 30 40 50 MRSWVVGARL LLLLQLVLVL GAVRLPPCTD PRHCTDPPRY TPDWPSLDSR ...
- View our 1 alpha-L-Fucosidase products for cell biology research. ... R&D Systems uses cookies to give you the best experience on our website. If you continue to use our services, we'll assume that you're happy with this.
★リンクテーブル★
[★]
- 英
- alpha-L-fucosidase
- 関
- フコシダーゼ
[★]
[★]
フコシダーゼ、フコシド分解酵素
- 関
- alpha-L-fucosidase
[★]
α、アルファ
- 関
- alfa